8EKH
| I-2 Y35N H35N (unbound) Fab from CH65-CH67 lineage | Descriptor: | I-2 Fab heavy chain, I-2 Fab light chain | Authors: | Maurer, D.P, Schmidt, A.G. | Deposit date: | 2022-09-21 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody. Elife, 12, 2023
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7NMC
| Crystal structure of beta-2-microglobulin D76E mutant | Descriptor: | Beta-2-microglobulin, GLYCEROL, TRIETHYLENE GLYCOL | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NMV
| Crystal structure of beta-2-microglobulin D76Q mutant | Descriptor: | Beta-2-microglobulin | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NMY
| Crystal structure of beta-2-microglobulin D76Y mutant | Descriptor: | Beta-2-microglobulin | Authors: | Guthertz, N. | Deposit date: | 2021-02-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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8EZ2
| Plasmodium falciparum M1 in complex with inhibitor 15ag | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... | Authors: | Calic, P.P.S, McGowan, S, Webb, C.T. | Deposit date: | 2022-10-31 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation. Eur.J.Med.Chem., 248, 2022
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5M4A
| Neutral trehalase Nth1 from Saccharomyces cerevisiae in complex with trehalose | Descriptor: | Neutral trehalase, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose | Authors: | Smidova, A, Alblova, M, Obsilova, V, Obsil, T. | Deposit date: | 2016-10-18 | Release date: | 2017-11-01 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7NN5
| Crystal structure of beta-2-microglobulin D76K mutant | Descriptor: | Beta-2-microglobulin | Authors: | Guthertz, N. | Deposit date: | 2021-02-24 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.242 Å) | Cite: | The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proc.Natl.Acad.Sci.USA, 119, 2022
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8EYF
| Plasmodium falciparum M1 in complex with inhibitor 15aa | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... | Authors: | Calic, P.P.S, McGowan, S, Webb, C.T. | Deposit date: | 2022-10-26 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation. Eur.J.Med.Chem., 248, 2022
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7NAD
| State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb4 local refinement model | Descriptor: | 25S rRNA, 5.8S rRNA, 60S ribosomal protein L17-A, ... | Authors: | Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. | Deposit date: | 2021-06-21 | Release date: | 2022-11-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat.Struct.Mol.Biol., 29, 2022
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8VCH
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8VIG
| EgtB-IV from Geminocystis sp. isolate SKYG4, an ergothioneine-biosynthetic type IV sulfoxide synthase in complex with hercynine | Descriptor: | 1,2-ETHANEDIOL, FE (III) ION, N,N,N-trimethyl-histidine, ... | Authors: | Ireland, K.A, Davis, K.M. | Deposit date: | 2024-01-04 | Release date: | 2024-08-07 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA. Structure, 2024
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8VIL
| EgtB-IV from Crocosphaera subtropica, an ergothioneine-biosynthetic type IV sulfoxide synthase in complex with N,N-dimethyl-histidine | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | Authors: | Ireland, K.A, Davis, K.M. | Deposit date: | 2024-01-04 | Release date: | 2024-08-07 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA. Structure, 2024
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8CGW
| Insulin-regulated aminopeptidase (IRAP) in complex with an allosteric benzopyran-based inhibitor | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mpakali, A, Stratikos, E, Giastas, P. | Deposit date: | 2023-02-06 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase. J.Mol.Biol., 436, 2024
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7TYV
| Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 25.10C Fab Heavy Chain, ... | Authors: | Enriquez, A.S, Hastie, K.M. | Deposit date: | 2022-02-14 | Release date: | 2022-06-01 | Last modified: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies. Cell Rep, 39, 2022
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7U21
| Human Class I MHC HLA-A2 in complex with AVGSYVYSV peptide | Descriptor: | Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ... | Authors: | Weiss, L.I, Baker, B.M. | Deposit date: | 2022-02-22 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Physicochemical Heuristics for Identifying High Fidelity, Near-Native Structural Models of Peptide/MHC Complexes. Front Immunol, 13, 2022
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7LTN
| Crystal structure of Mpro in complex with inhibitor CDD-1713 | Descriptor: | 2-[4-(1~{H}-indazol-4-yl)-2-methanoyl-6-methoxy-phenoxy]-~{N},~{N}-dimethyl-ethanamide, 3C-like proteinase | Authors: | Lu, S, Palzkill, T, Matzuk, M, Young, D, Melek, N, Chamakuri, S. | Deposit date: | 2021-02-19 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors. Proc.Natl.Acad.Sci.USA, 118, 2021
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8VB1
| Crystal structure of HIV-1 protease with GS-9770 | Descriptor: | (2S)-2-{(3M)-4-chloro-3-[1-(difluoromethyl)-1H-1,2,4-triazol-5-yl]phenyl}-2-[(2E,4R)-4-[4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)phenyl]-2-imino-5-oxo-4-(3,3,3-trifluoro-2,2-dimethylpropyl)imidazolidin-1-yl]ethyl [1-(difluoromethyl)cyclopropyl]carbamate, HIV-1 protease | Authors: | Lansdon, E.B. | Deposit date: | 2023-12-11 | Release date: | 2024-03-06 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrob.Agents Chemother., 68, 2024
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8V2D
| Computational Designed Nanocage O43_129 | Descriptor: | O43_129 component A, O43_129 component B | Authors: | Weidle, C, Kibler, R.D. | Deposit date: | 2023-11-22 | Release date: | 2024-03-13 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (6.77 Å) | Cite: | Blueprinting extendable nanomaterials with standardized protein blocks. Nature, 627, 2024
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7M76
| Room Temperature XFEL Crystallography reveals asymmetry in the vicinity of the two phylloquinones in Photosystem I | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | Authors: | Keable, S.M, Simon, P.S, Kolsch, A, Kern, J, Yachandra, V.K, Zouni, A, Yano, J. | Deposit date: | 2021-03-26 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Room temperature XFEL crystallography reveals asymmetry in the vicinity of the two phylloquinones in photosystem I. Sci Rep, 11, 2021
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7Y17
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7MGT
| Ftp from Treponema pallidum bound to an ADP-like inhibitor | Descriptor: | 1,2-ETHANEDIOL, 2-chloroadenosine 5'-(trihydrogen diphosphate), FAD:protein FMN transferase, ... | Authors: | Brautigam, C.A, Deka, R, Norgard, M.V. | Deposit date: | 2021-04-13 | Release date: | 2021-12-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Inhibition of bacterial FMN transferase: A potential avenue for countering antimicrobial resistance. Protein Sci., 31, 2022
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7Y16
| Crystal structure of rRNA-processing protein Las1 | Descriptor: | LAS1 protein | Authors: | Chen, J, Liu, L. | Deposit date: | 2022-06-07 | Release date: | 2023-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery. Elife, 12, 2024
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7VWS
| Carbazole Prenyl Transferase LvqB4 | Descriptor: | 2-methyl-1-[(2R)-2-oxidanylpropyl]-9H-carbazole-3,4-dione, LvqB4, MAGNESIUM ION, ... | Authors: | Suemune, H, Nagata, R, Kuzuyama, T, Nagano, S. | Deposit date: | 2021-11-11 | Release date: | 2022-03-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-Like Enzymes. Angew.Chem.Int.Ed.Engl., 61, 2022
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7VWT
| Carbazole Prenyl Transferase CqsB4 | Descriptor: | 2-methyl-1-[(2R)-2-oxidanylpropyl]-9H-carbazole-3,4-dione, CqsB4, DI(HYDROXYETHYL)ETHER, ... | Authors: | Suemune, H, Nagata, R, Kuzuyama, T, Nagano, S. | Deposit date: | 2021-11-11 | Release date: | 2022-03-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-Like Enzymes. Angew.Chem.Int.Ed.Engl., 61, 2022
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8CTJ
| Cryo-EM structure of TMEM87A | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Transmembrane protein 87A | Authors: | Hoel, C.M, Zhang, L, Brohawn, S.G. | Deposit date: | 2022-05-15 | Release date: | 2022-07-20 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (4.74 Å) | Cite: | Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Elife, 11, 2022
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