9DN4
 
 | | Crystal structure of a SARS-CoV-2 20-mer RNA in complex with FAB BL3-6S97N | | Descriptor: | CHLORIDE ION, FAB BL3-6S97N HEAVY CHAIN, FAB BL3-6S97N LIGHT CHAIN, ... | | Authors: | Lovell, S, Cooper, A, Battaile, K.P, Hegde, S, Wang, J. | | Deposit date: | 2024-09-16 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of a SARS-CoV-2 20-mer RNA in complex with FAB BL3-6S97N
To be published
|
|
9DMZ
 | | Glycosylated chronic wasting disease prion fibril | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Major prion protein | | Authors: | Caughey, B, Hoyt, F, Alam, P, Artikis, E, Soukup, J, Hughson, A, Schwartz, C, Race, B, Barbian, K. | | Deposit date: | 2024-09-16 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer.
Acta Neuropathol, 148, 2024
|
|
9DMY
 | | Chronic wasting disease prion fibril | | Descriptor: | Major prion protein | | Authors: | Caughey, B, Hoyt, F, Alam, P, Artikis, E, Soukup, J, Hughson, A, Schwartz, C, Race, B, Barbian, K. | | Deposit date: | 2024-09-16 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer.
Acta Neuropathol, 148, 2024
|
|
9DM1
 | | Mycobacterial supercomplex malate:quinone oxidoreductase assembly | | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | | Authors: | Di Trani, J.M, Rubinstein, J.L. | | Deposit date: | 2024-09-11 | | Release date: | 2024-10-23 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM of native membranes reveals an intimate connection between Krebs cycle and respiration in mycobacteria
To Be Published
|
|
9DLW
 | | Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-41114 | | Descriptor: | DDB1- and CUL4-associated factor 1, N-{(1P)-5'-({(32E)-33-[(3P)-4-{[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-31-oxo-3,6,9,12,15,18,21,24,27-nonaoxa-30-azatritriacont-32-en-1-yl}carbamoyl)-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, WD repeat-containing protein 5 | | Authors: | Mabanglo, M.F, Mamai, A, Wilson, B.J, Hoffer, L, Al-awar, R, Vedadi, M. | | Deposit date: | 2024-09-11 | | Release date: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Crystal structures of DCAF1-PROTAC-WDR5 complexes provide insight into DCAF1 substrate specificity
To Be Published
|
|
9DLL
 | | NMR structures of small molecules bound to a model of an RNA CAG repeat expansion. | | Descriptor: | 4-carbamimidamidophenyl 4-carbamimidamidobenzoate, CAG 13-mer RNA (5'-R(*GP*AP*CP*AP*GP*CP*AP*GP*CP*UP*GP*UP*C)-3') | | Authors: | Chen, J.L, Taghavi, A, Disney, M.D, Fountain, M.A, Childs-Disney, J.L. | | Deposit date: | 2024-09-11 | | Release date: | 2024-09-25 | | Method: | SOLUTION NMR | | Cite: | NMR structures of small molecules bound to a model of an RNA CAG repeat expansion.
Nucleic Acids Res., 2024
|
|
9DKZ
 | | In situ microED structure of the Eosinophil major basic protein-1 | | Descriptor: | Bone marrow proteoglycan | | Authors: | Yang, J.E, Bingman, C.A, Mitchell, J, Mosher, D, Wright, E.R. | | Deposit date: | 2024-09-10 | | Release date: | 2024-09-25 | | Last modified: | 2024-11-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (3.2 Å) | | Cite: | In situ crystalline structure of the human eosinophil major basic protein-1.
Biorxiv, 2024
|
|
9DK4
 | | ancestral hydroxynitrile lyase with fifteen substitutions | | Descriptor: | Fifteen-substitution variant of an ancestral hydroxynitrile lyase, SODIUM ION | | Authors: | Sarak, S.C, Tan, P, Evans III, R.L, Shi, K, Kazlauskas, R.J, Aihara, H, Pierce, C.T, Walsh, M.E, Greenberg, L.R. | | Deposit date: | 2024-09-07 | | Release date: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | To be published
To Be Published
|
|
9DJ9
 | | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in distinct apo form | | Descriptor: | Dual specificity protein phosphatase 3 | | Authors: | Keedy, D.A, Lemberikman, A.M, Isiorho, E.A, Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | | Deposit date: | 2024-09-06 | | Release date: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (1.924 Å) | | Cite: | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock
To Be Published
|
|
9DHL
 | |
9DHJ
 | | DHODH in complex with Compound 15 | | Descriptor: | (2M,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-[(2R)-1,1,1-trifluoropropan-2-yl]phthalazin-1(2H)-one, 1,2-ETHANEDIOL, ACETATE ION, ... | | Authors: | Shaffer, P.L. | | Deposit date: | 2024-09-03 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Identification of isoquinolinone DHODH inhibitor isosteres.
Bioorg.Med.Chem.Lett., 113, 2024
|
|
9DHI
 | | DHODH in complex with Compound 7 | | Descriptor: | (2M,6P)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-(propan-2-yl)phthalazin-1(2H)-one, 1,2-ETHANEDIOL, ACETATE ION, ... | | Authors: | Shaffer, P.L. | | Deposit date: | 2024-09-03 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Identification of isoquinolinone DHODH inhibitor isosteres.
Bioorg.Med.Chem.Lett., 113, 2024
|
|
9DHH
 | | DHODH in complex with Compound 8 | | Descriptor: | (3S,7P)-7-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-6-fluoro-3-(2-methylphenyl)-1-(propan-2-yl)-2,3-dihydroquinolin-4(1H)-one, 1,2-ETHANEDIOL, ACETATE ION, ... | | Authors: | Shaffer, P.L. | | Deposit date: | 2024-09-03 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Identification of isoquinolinone DHODH inhibitor isosteres.
Bioorg.Med.Chem.Lett., 113, 2024
|
|
9DHG
 | | DHODH in complex with Compound 5 | | Descriptor: | (3P,7P)-7-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-6-fluoro-3-(2-methylphenyl)-1-(propan-2-yl)quinolin-4(1H)-one, 1,2-ETHANEDIOL, ACETATE ION, ... | | Authors: | Shaffer, P.L. | | Deposit date: | 2024-09-03 | | Release date: | 2024-10-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.386 Å) | | Cite: | Identification of isoquinolinone DHODH inhibitor isosteres.
Bioorg.Med.Chem.Lett., 113, 2024
|
|
9DG1
 | |
9DF0
 | | PDCoV S RBD bound to PD41 Fab (local refinement) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PD41 Fab variable heavy-chain, PD41 Fab variable light-chain, ... | | Authors: | Asarnow, D, Rexhepaj, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D. | | Deposit date: | 2024-08-29 | | Release date: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses.
Immunity, 2024
|
|
9DEZ
 | | PDCoV S trimer bound by three copies of PD41 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITOLEIC ACID, ... | | Authors: | Asarnow, D, Rexhepaj, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2024-08-29 | | Release date: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses.
Immunity, 2024
|
|
9DER
 | | Cryo-EM Structures of Full-Length Integrin alphaIIbbeta3 in Native Lipids Complexed with Tirofiban | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-IIb, ... | | Authors: | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | | Deposit date: | 2024-08-29 | | Release date: | 2024-10-16 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Platelet integrin alpha IIb beta 3 plays a key role in a venous thrombogenesis mouse model.
Nat Commun, 15, 2024
|
|
9DEQ
 | | Cryo-EM structures of full-length integrin alphaIIbbeta3 in native lipids complexed with modified tirofiban | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | | Deposit date: | 2024-08-29 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Platelet integrin alpha IIb beta 3 plays a key role in a venous thrombogenesis mouse model.
Nat Commun, 15, 2024
|
|
9DE2
 | | ETO2 MYND bound to MPPL peptide from GATAD2A | | Descriptor: | GATAD2A-MPPL motif and ETO2 NHR4 domain fusion protein, ZINC ION | | Authors: | Williams, D.C. | | Deposit date: | 2024-08-28 | | Release date: | 2024-09-18 | | Method: | SOLUTION NMR | | Cite: | The role of multivalency in the association of the eight twenty-one protein 2 (ETO2) with the nucleosome remodeling and deacetylase (NuRD) complex
To Be Published
|
|
9DDY
 | | The Crystal Structure of Geranyltranstransferase from Streptococcus pneumoniae TIGR4 | | Descriptor: | GLYCEROL, Geranyltranstransferase | | Authors: | Kim, Y, Tan, A, Endres, M, Tan, K, Joachimik, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-08-28 | | Release date: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | The Crystal Structure of Geranyltranstransferase from Streptococcus pneumoniae TIGR4
To Be Published
|
|
9DCN
 | |
9DCG
 | | Crystal Structure of the Thiol:Disulfide Interchange Protein DsbC from Vibrio cholerae | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FORMIC ACID, ... | | Authors: | Kim, Y, Maltseva, N, Shatsman, S, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-08-26 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Crystal Structure of the Thiol:Disulfide Interchange Protein DsbC from Vibrio cholerae
To Be Published
|
|
9DB5
 | | A DARPin fused to the 1TEL crystallization chaperone via a proline-alanine linker | | Descriptor: | ACETIC ACID, CHLORIDE ION, SODIUM ION, ... | | Authors: | Pedroza Romo, M.J, Averett, J.C, Keliiliki, A, Wilson, E.W, Smith, C, Hansen, D, Averett, B, Gonzalez, J, Noakes, E, Nickles, R, Doukov, T, Moody, J.D. | | Deposit date: | 2024-08-23 | | Release date: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Optimal TELSAM-Target Protein Linker Character is Target Protein Dependent
To Be Published
|
|
9DB2
 | | Class Ia ribonucleotide reductase with mechanism-based inhibitor N3CDP | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 4-amino-1-{(3xi)-3-C-amino-2-deoxy-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-beta-D-threo-pentofuranosyl}pyrimidin-2(1H)-one, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Westmoreland, D.E, Drennan, C.L. | | Deposit date: | 2024-08-23 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | 2.6- angstrom resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor N 3 CDP.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
