PDB: 327 resultsInfo pagesStatus searchChemie searchBIRD

---

5E17	T. thermophilus transcription initiation complex having a RRR discriminator sequence and a nontemplate-strand length corresponding to TSS selection at position 7 (RPo-GGG-7) Descriptor: DNA (27-MER), DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-09-29 Release date: 2016-03-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection. Science, 351, 2016
7UBM	Transcription antitermination complex: "pre-engaged" Qlambda-loading complex Descriptor: Antitermination protein Q, DNA (52-MER), DNA (53-MER), ... Authors: Yin, Z, Ebright, R.H. Deposit date: 2022-03-15 Release date: 2022-09-28 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
7UBN	Transcription antitermination complex: NusA-containing "engaged" Qlambda-loading complex Descriptor: Antitermination protein, DNA (52-MER), DNA (53-MER), ... Authors: Yin, Z, Ebright, R.H. Deposit date: 2022-03-15 Release date: 2022-09-28 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.36 Å) Cite: In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
7SZJ	Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex Descriptor: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Shin, Y, Murakami, K.S. Deposit date: 2021-11-28 Release date: 2022-07-13 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.11 Å) Cite: Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7U22	Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7 Descriptor: (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Molodtsov, V, Ebright, R.H. Deposit date: 2022-02-22 Release date: 2022-10-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.87 Å) Cite: Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angew.Chem.Int.Ed.Engl., 61, 2022
5D4D	Crystal structure of Thermus thermophilus product complex for transcription initiation with NAD and CTP Descriptor: ADENOSINE MONOPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (3 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
5D4C	Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-07-03 Method: X-RAY DIFFRACTION (3.28 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
1SC5	Sigma-28(FliA)/FlgM complex Descriptor: RNA polymerase sigma factor FliA, anti-sigma factor FlgM Authors: Sorenson, M.K, Ray, S.S, Darst, S.A. Deposit date: 2004-02-11 Release date: 2004-04-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.26 Å) Cite: Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation. Mol.Cell, 14, 2004
8X6G	Cryo-EM structure of Staphylococcus aureus sigB-dependent RNAP-promoter open complex Descriptor: DNA (70-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yuan, L, Xu, L, Liu, Q, Feng, Y. Deposit date: 2023-11-21 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase. Nat Commun, 15, 2024
8X6F	Cryo-EM structure of Staphylococcus aureus sigA-dependent RNAP-promoter open complex Descriptor: DNA (71-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yuan, L, Xu, L, Liu, Q, Feng, Y. Deposit date: 2023-11-21 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase. Nat Commun, 15, 2024
1IW7	Crystal structure of the RNA polymerase holoenzyme from Thermus thermophilus at 2.6A resolution Descriptor: LEAD (II) ION, MAGNESIUM ION, RNA polymerase alpha subunit, ... Authors: RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2002-04-22 Release date: 2002-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution NATURE, 417, 2002
8W8N	Thermus thermophilus initiation transcription complex in the pre-translocated state Descriptor: DNA (21-MER), DNA (27-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (2.693 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
8W8P	Thermus thermophilus initiation transcription complex containing CMPcPP in the post-translocated state Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (21-MER), DNA (27-MER), ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (3.165 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
8W8O	Thermus thermophilus initiation complex in the half-translocated state Descriptor: DNA (21-MER), DNA (27-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2023-09-04 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (2.512 Å) Cite: Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
4G7H	Crystal structure of Thermus thermophilus transcription initiation complex Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
8CWR	Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group R3 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IRON/SULFUR CLUSTER, NICKEL (II) ION, ... Authors: Wan, T, Zhang, L. Deposit date: 2022-05-19 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
8CWT	Complex structure of WhiB3 and the SigmaAr4-RNAP Beta flap tip chimera in space group P43212 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IRON/SULFUR CLUSTER, NICKEL (II) ION, ... Authors: Wan, T, Zhang, L. Deposit date: 2022-05-19 Release date: 2023-05-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
8CYF	WhiB3 bound to SigmaAr4-RNAP Beta flap tip chimera and DNA Descriptor: CACODYLATE ION, DNA (5'-D(*CP*AP*CP*CP*AP*CP*AP*AP*CP*CP*GP*AP*TP*TP*TP*T)-3'), DNA (5'-D(*GP*AP*AP*AP*AP*TP*CP*GP*GP*TP*TP*GP*TP*GP*GP*T)-3'), ... Authors: Wan, T, Zhang, L.M. Deposit date: 2022-05-23 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2023
8D5V	WhiB6 bound to the SigmaAr4-RNAP Beta flap tip chimera Descriptor: IRON/SULFUR CLUSTER, Probable transcriptional regulator WhiB6, RNA polymerase sigma factor SigA,DNA-directed RNA polymerase subunit beta Authors: Wan, T, Zhang, L.M. Deposit date: 2022-06-06 Release date: 2023-06-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of WhiB6 and SigA4-betaTip complex To Be Published
8Y6U	Cryo-EM structure of E.coli transcription initiation complex with transcription factor GcvA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Shi, J. Deposit date: 2024-02-03 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (3.97 Å) Cite: NMR analysis of a loop-bulge structure of UUCGA pentaloop. Biochem.Biophys.Res.Commun., 691, 2024
1RP3	Cocrystal structure of the flagellar sigma/anti-sigma complex, Sigma-28/FlgM Descriptor: RNA polymerase sigma factor SIGMA-28 (FliA), anti sigma factor FlgM Authors: Sorenson, M.K, Ray, S.S, Darst, S.A. Deposit date: 2003-12-02 Release date: 2004-04-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of the Flagellar Sigma/Anti-Sigma Complex Sigma(28)/FlgM Reveals an Intact Sigma Factor in an Inactive Conformation Mol.Cell, 14, 2004
1RIO	Structure of bacteriophage lambda cI-NTD in complex with sigma-region4 of Thermus aquaticus bound to DNA Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 27-MER, CALCIUM ION, ... Authors: Jain, D, Nickels, B.E, Sun, L, Hochschild, A, Darst, S.A. Deposit date: 2003-11-17 Release date: 2004-01-27 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of a ternary transcription activation complex. Mol.Cell, 13, 2004
8DY7	Streptomyces venezuelae RNAP transcription open promoter complex with WhiA and WhiB transcription factors Descriptor: DNA (71-MER), DNA (78-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Campbell, E.A. Deposit date: 2022-08-03 Release date: 2023-03-01 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
8DY9	Streptomyces venezuelae RNAP unconstrained open promoter complex with WhiA and WhiB transcription factors Descriptor: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lilic, M, Campbell, E.A. Deposit date: 2022-08-03 Release date: 2023-03-01 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
8U3B	Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A Descriptor: DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Kompaniiets, D, Wang, D. Deposit date: 2023-09-07 Release date: 2024-01-17 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Structural basis for transcription activation by the nitrate-responsive regulator NarL. Nucleic Acids Res., 52, 2024

<1234567891011121314>