6E6H
| NRAS G13D bound to GppNHp (N13GNP) | 分子名称: | GTPase NRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Johnson, C.W, Mattos, C. | 登録日 | 2018-07-24 | 公開日 | 2019-07-31 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep, 28, 2019
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6FA3
| Antibody derived (Abd-6) small molecule binding to KRAS. | 分子名称: | DIMETHYL SULFOXIDE, GTPase KRas, MAGNESIUM ION, ... | 著者 | Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H. | 登録日 | 2017-12-15 | 公開日 | 2018-08-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
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6FA2
| Antibody derived (Abd-5) small molecule binding to KRAS. | 分子名称: | 4-[2-(dimethylamino)ethoxy]-~{N}-[[(3~{R})-5-(6-methoxypyridin-2-yl)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide, GTPase KRas, MAGNESIUM ION, ... | 著者 | Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H. | 登録日 | 2017-12-15 | 公開日 | 2018-09-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
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6FA4
| Antibody derived (Abd-7) small molecule binding to KRAS. | 分子名称: | 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[4-[(dimethylamino)methyl]phenyl]-2-methoxy-pyridin-3-amine, GTPase KRas, MAGNESIUM ION, ... | 著者 | Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H. | 登録日 | 2017-12-15 | 公開日 | 2018-08-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
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6F76
| Antibody derived (Abd-8) small molecule binding to KRAS. | 分子名称: | 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline, GTPase KRas, MAGNESIUM ION, ... | 著者 | Bery, N, Cruz-Migoni, A, Quevedo, C.E, Phillips, S.V.E, Carr, S, Rabbitts, T.H. | 登録日 | 2017-12-07 | 公開日 | 2018-08-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions. Elife, 7, 2018
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6FA1
| Antibody derived (Abd-4) small molecule binding to KRAS. | 分子名称: | 2-[4-[[(3~{R})-2,3-dihydro-1,4-benzodioxin-3-yl]methylcarbamoyl]phenoxy]ethyl-dimethyl-azanium, GTPase KRas, MAGNESIUM ION, ... | 著者 | Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H. | 登録日 | 2017-12-15 | 公開日 | 2018-08-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
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6FF8
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3OES
| Crystal structure of the small GTPase RhebL1 | 分子名称: | GTPase RhebL1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Nedyalkova, L, Zhong, N, Tempel, W, Tong, Y, Shen, L, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-08-13 | 公開日 | 2010-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Crystal structure of the small GTPase RhebL1 to be published
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3OIW
| H-RasG12V with allosteric switch in the "on" state | 分子名称: | ACETATE ION, CALCIUM ION, GTPase HRas, ... | 著者 | Kumar, S, Buhrman, G, Mattos, C. | 登録日 | 2010-08-20 | 公開日 | 2010-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286, 2011
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3OIU
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3OIV
| H-RasG12V with allosteric switch in the "off" state | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GTPase HRas, ... | 著者 | Buhrman, G, Mattos, C. | 登録日 | 2010-08-20 | 公開日 | 2010-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.837 Å) | 主引用文献 | Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286, 2011
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3PIR
| Crystal structure of M-RasD41E in complex with GppNHp (type 1) | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras | 著者 | Muraoka, S, Matsumoto, K, Shima, F, Hu, L, Ijiri, Y, Hirai, R, Liao, J, Kataoka, T. | 登録日 | 2010-11-07 | 公開日 | 2011-03-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of M-RasD41E in complex with GppNHp (type 1) To be Published
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3PIT
| Crystal structure of M-RasD41E in complex with GppNHp (type 2) | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras | 著者 | Muraoka, S, Matsumoto, K, Shima, F, Hu, L, Ijiri, Y, Hirai, R, Liao, J, Kataoka, T. | 登録日 | 2010-11-08 | 公開日 | 2011-03-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal structure of M-RasD41E in complex with GppNHp (type 2) To be Published
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3Q72
| Crystal Structure of Rad G-domain-GTP Analog Complex | 分子名称: | CALCIUM ION, GTP-binding protein RAD, MAGNESIUM ION, ... | 著者 | Sasson, Y, Navon-Perry, L, Hirsch, J.A. | 登録日 | 2011-01-04 | 公開日 | 2011-09-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.655 Å) | 主引用文献 | RGK Family G-Domain:GTP Analog Complex Structures and Nucleotide-Binding Properties. J.Mol.Biol., 413, 2011
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3Q7P
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3Q7Q
| Crystal Structure of Rad G-domain Q148A-GTP Analog Complex | 分子名称: | CALCIUM ION, GTP-binding protein RAD, MAGNESIUM ION, ... | 著者 | Sasson, Y, Navon-Perry, L, Hirsch, J.A. | 登録日 | 2011-01-05 | 公開日 | 2011-09-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | RGK Family G-Domain:GTP Analog Complex Structures and Nucleotide-Binding Properties. J.Mol.Biol., 413, 2011
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3Q85
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3RAN
| CANINE GDP-RAN Q69L MUTANT | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (GTP-BINDING NUCLEAR PROTEIN RAN) | 著者 | Stewart, M, Kent, H.M, Mccoy, A.J. | 登録日 | 1998-10-19 | 公開日 | 1998-12-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2). J.Mol.Biol., 284, 1998
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3REG
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3RS3
| H-Ras soaked in neat hexane: 1 of 10 in MSCS set | 分子名称: | CALCIUM ION, GTPase HRas, HEXANE, ... | 著者 | Mattos, C, Buhrman, G, Kearney, B. | 登録日 | 2011-05-02 | 公開日 | 2011-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Analysis of Binding Site Hot Spots on the Surface of Ras GTPase. J.Mol.Biol., 413, 2011
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3RSL
| H-Ras soaked in 90% R,S,R-bisfuranol: one of 10 in MSCS set | 分子名称: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol, CALCIUM ION, GTPase HRas, ... | 著者 | Mattos, C, Buhrman, G, Kearney, B. | 登録日 | 2011-05-02 | 公開日 | 2011-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Analysis of Binding Site Hot Spots on the Surface of Ras GTPase. J.Mol.Biol., 413, 2011
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3RAP
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3RS7
| H-Ras soaked in 50% isopropanol: 1 of 10 in MSCS set | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Mattos, C, Buhrman, G, Kearney, B. | 登録日 | 2011-05-02 | 公開日 | 2011-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Analysis of Binding Site Hot Spots on the Surface of Ras GTPase. J.Mol.Biol., 413, 2011
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3REF
| Crystal structure of EhRho1 bound to GDP and Magnesium | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho-like small GTPase, ... | 著者 | Bosch, D.E, Qiu, C, Siderovski, D.P. | 登録日 | 2011-04-04 | 公開日 | 2011-09-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica. J.Biol.Chem., 286, 2011
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3RRZ
| H-Ras in 70% glycerol: one of 10 in MSCS set | 分子名称: | CALCIUM ION, GLYCEROL, GTPase HRas, ... | 著者 | Mattos, C, Buhrman, G, Kearney, B. | 登録日 | 2011-05-02 | 公開日 | 2011-09-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Analysis of Binding Site Hot Spots on the Surface of Ras GTPase. J.Mol.Biol., 413, 2011
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