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12CA	ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121 Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1991-10-01 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121. J.Biol.Chem., 266, 1991
1AM6	CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE Descriptor: ACETOHYDROXAMIC ACID, CARBONIC ANHYDRASE, MERCURY (II) ION, ... Authors: Scolnick, L.R, Clements, A.M, Christianson, D.W. Deposit date: 1997-06-24 Release date: 1998-06-24 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Novel Binding Mode of Hydroxamate Inhibitors to Human Carbonic Anhydrase II J.Am.Chem.Soc., 119, 1997
1A42	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE Descriptor: (4R)-2-(2-ethoxyethyl)-4-(ethylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Christianson, D.W. Deposit date: 1998-02-10 Release date: 1999-03-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci., 7, 1998
1AZM	DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE I, ZINC ION Authors: Chakravarty, S, Kannan, K.K. Deposit date: 1993-11-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme. J.Mol.Biol., 243, 1994
1BCD	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE Descriptor: CARBONIC ANHYDRASE II, TRIFLUOROMETHANE SULFONAMIDE, ZINC ION Authors: Hakansson, K, Liljas, A. Deposit date: 1993-08-31 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide. FEBS Lett., 350, 1994
1AVN	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR Descriptor: AZIDE ION, CARBONIC ANHYDRASE II, HISTAMINE, ... Authors: Briganti, F, Mangani, S, Orioli, P, Scozzafava, A, Vernaglione, G, Supuran, C.T. Deposit date: 1997-09-17 Release date: 1997-12-24 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. Biochemistry, 36, 1997
1BIC	CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3- Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ... Authors: Xue, Y, Vidgren, J, Svensson, L.A, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-01 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-. Proteins, 15, 1993
1BN1	CARBONIC ANHYDRASE II INHIBITOR Descriptor: CARBONIC ANHYDRASE, MERCURY (II) ION, THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE), ... Authors: Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. Deposit date: 1998-07-31 Release date: 1999-05-18 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BZM	DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I Descriptor: CARBONIC ANHYDRASE I, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION Authors: Chakravarty, S, Kannan, K.K. Deposit date: 1993-11-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme. J.Mol.Biol., 243, 1994
1BV3	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, PROTEIN (CARBONIC ANHYDRASE II), UREA, ... Authors: Briganti, F, Mangani, S, Scozzafava, A, Vernaglione, G, Supuran, C.T. Deposit date: 1998-09-22 Release date: 1999-09-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction? J.Biol.Inorg.Chem., 4, 1999
1CAK	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CA3	UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1991-11-18 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II. J.Am.Chem.Soc., 113, 1991
1CAJ	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CAH	STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, COBALT (II) ION Authors: Hakansson, K, Wehnert, A. Deposit date: 1992-06-25 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structure of cobalt carbonic anhydrase complexed with bicarbonate. J.Mol.Biol., 228, 1992
1CAO	CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS Descriptor: CARBONIC ANHYDRASE II, HYDROSULFURIC ACID, ZINC ION Authors: Mangani, S, Hakansson, K. Deposit date: 1992-07-02 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions. Eur.J.Biochem., 210, 1992
1CCU	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-12-09 Release date: 1995-02-07 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proc.Natl.Acad.Sci.USA, 92, 1995
1CAN	CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, NITRATE ION Authors: Mangani, S, Hakansson, K. Deposit date: 1992-07-02 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions. Eur.J.Biochem., 210, 1992
1CAY	WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE Descriptor: ACETIC ACID, CARBONIC ANHYDRASE II, ZINC ION Authors: Hakansson, K, Briand, C, Zaitsev, V, Xue, Y, Liljas, A. Deposit date: 1993-02-26 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Wild-type and E106Q mutant carbonic anhydrase complexed with acetate. Acta Crystallogr.,Sect.D, 50, 1994
1CCT	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-12-09 Release date: 1995-02-07 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proc.Natl.Acad.Sci.USA, 92, 1995
1CAM	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE II, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CAZ	WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE Descriptor: ACETIC ACID, CARBONIC ANHYDRASE II, ZINC ION Authors: Hakansson, K, Briand, C, Zaitsev, V, Xue, Y, Liljas, A. Deposit date: 1993-02-26 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Wild-type and E106Q mutant carbonic anhydrase complexed with acetate. Acta Crystallogr.,Sect.D, 50, 1994
1CA2	REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Eriksson, A.E, Jones, T.A, Liljas, A. Deposit date: 1989-02-06 Release date: 1990-01-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Refined structure of human carbonic anhydrase II at 2.0 A resolution. Proteins, 4, 1988
1CAL	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CAI	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION Authors: Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. Deposit date: 1992-09-17 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CCS	STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Ippolito, J.A, Christianson, D.W. Deposit date: 1994-12-09 Release date: 1995-02-07 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proc.Natl.Acad.Sci.USA, 92, 1995

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