1AZM

DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I

Summary for 1AZM

DescriptorCARBONIC ANHYDRASE I, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ... (4 entities in total)
Functional Keywordsprotein-drug interactions, oxo-acid lyase, sulfonamides, lyase(oxo-acid)
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P00915
Total number of polymer chains1
Total molecular weight29062.64
Authors
Chakravarty, S.,Kannan, K.K. (deposition date: 1993-11-28, release date: 1994-04-30, Last modification date: 2017-11-29)
Primary citation
Chakravarty, S.,Kannan, K.K.
Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme.
J.Mol.Biol., 243:298-309, 1994
PubMed: 7932756 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1994.1655
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers130.4%4.5%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution