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8BYE	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075313) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclobutane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWJ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074386) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-2-[4-(trifluoromethyl)phenoxy]propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-06 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX4	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074392) Descriptor: 14-3-3 protein sigma, 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXO	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075287) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4,4-bis(fluoranyl)-1-phenoxy-cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXQ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075296) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-phenoxy-cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BY9	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075292) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)-4,4-bis(fluoranyl)cyclohexane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZ0	single soak stabilizer for ERa - 14-3-3 interaction (AZ275) Descriptor: 14-3-3 protein sigma, 4-ethoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZA	single soak stabilizer for ERa - 14-3-3 interaction (AZ555) Descriptor: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.25 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4G	Small molecule amidine soak in 14-3-3/ERa (AZ132) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.46 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXS	Fragment-linked stabilizer for ERa - 14-3-3 interaction (1075293) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-(4-chloranylphenoxy)oxane-4-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (AZ210) Descriptor: 14-3-3 protein sigma, 4-[(2~{S})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXI	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-08 Release date: 2023-08-02 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYD	fragment-linked stabilizer for ERa - 14-3-3 interactions (1075288) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclopentane-1-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWX	Fragment-linked stabilizer for 14-3-3 and ERa (1075298) Descriptor: 14-3-3 protein sigma, 4-azanyl-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide, ERalpha peptide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYF	fragment-linked stabilizer for ERa - 14-3-3 interaction (1047455) Descriptor: 14-3-3 protein sigma, PHE-PRO-ALA-TPO-VAL, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-chloranylphenoxy)-2-methyl-propanamide Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYC	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075316) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C0K	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-17 Release date: 2023-08-02 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX3	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074372) Descriptor: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.2 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXN	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074399) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-phenoxy-oxane-4-carboxamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYY	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074395) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-[(4-chlorophenyl)amino]-2-methyl-propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-14 Release date: 2023-08-02 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F	Small molecule amidine soak in 14-3-3/ERa (AZ037) Descriptor: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2023-01-03 Release date: 2023-08-02 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX0	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074388) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-methoxyphenoxy)-2-methyl-propanamide Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-07 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXM	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074397) Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. Deposit date: 2022-12-09 Release date: 2023-08-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYG	fragment-linked stabilizer for ERa - 14-3-3 interaction (1047648) Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[2-[(2-carbamimidoyl-1-benzothiophen-4-yl)-methyl-amino]ethyl]-2-(4-chloranylphenoxy)-~{N},2-dimethyl-propanamide Authors: Visser, E.J, Sijbesma, E, Ottmann, C. Deposit date: 2022-12-12 Release date: 2023-08-30 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.7 Å) Cite: From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023

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