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5R8U	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N05703b in complex with MAP kinase p38-alpha Descriptor: 3,4-dihydro-2~{H}-chromene-6-carboxamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9B	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N13866a in complex with MAP kinase p38-alpha Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.657 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9S	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N13470a in complex with MAP kinase p38-alpha Descriptor: 5-(4-chlorophenyl)furan-2-carbohydrazide, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8V	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N09139b in complex with MAP kinase p38-alpha Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.479 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9A	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N13838a in complex with MAP kinase p38-alpha Descriptor: 4-benzamido-2-methyl-pyrazole-3-carboxamide, CHLORIDE ION, GLYCEROL, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9Q	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N07422b in complex with MAP kinase p38-alpha Descriptor: 1-phenylmethoxyurea, CHLORIDE ION, Mitogen-activated protein kinase 14, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.645 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5RA5	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N11302a in complex with MAP kinase p38-alpha Descriptor: (1~{S},5~{R})-8-methyl-8-azabicyclo[3.2.1]octan-3-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R91	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment KCL057 in complex with MAP kinase p38-alpha Descriptor: 2-[4-(2-aminophenyl)piperazin-1-yl]ethanol, ACETATE ION, CHLORIDE ION, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.731 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R9M	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N13418a in complex with MAP kinase p38-alpha Descriptor: CHLORIDE ION, MAGNESIUM ION, Mitogen-activated protein kinase 14, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.809 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5RA1	PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N08141b in complex with MAP kinase p38-alpha Descriptor: 2-phenoxyacetamide, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
8BGU	human MDM2-5S RNP Descriptor: 5S rRNA, 60S ribosomal protein L11, 60S ribosomal protein L5, ... Authors: Castillo, N, Thoms, M, Flemming, D, Hammaren, H.M, Buschauer, R, Ameismeier, M, Bassler, J, Beck, M, Beckmann, R, Hurt, E. Deposit date: 2022-10-28 Release date: 2023-06-14 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2-p53 pathways. Nat.Struct.Mol.Biol., 30, 2023
1N52	Cap Binding Complex Descriptor: 20 kDa nuclear cap binding protein, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, 80 kDa nuclear cap binding protein, ... Authors: Calero, G, Wilson, K, Ly, T, Rios-Steiner, J, Clardy, J, Cerione, R. Deposit date: 2002-11-04 Release date: 2003-02-18 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. Nat.Struct.Biol., 9, 2002
6OAR	Structure of the Kupe virus OTU bound to the C-terminal domain of sheep ISG15 Descriptor: Interferon stimulated gene 17, RNA-dependent RNA polymerase, prop-2-en-1-amine Authors: Dzimianski, J.V, Williams, I.L, Pegan, S.D. Deposit date: 2019-03-18 Release date: 2020-01-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.063 Å) Cite: Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases. Plos One, 14, 2019
8ARK	Crystal structure of DEAD-box protein Dbp2 in apo form Descriptor: ATP-dependent RNA helicase DBP2 Authors: Rety, S, Xi, X.G. Deposit date: 2022-08-17 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.22 Å) Cite: Nonstructural N- and C-tails of Dbp2 confer the protein full helicase activities. J.Biol.Chem., 299, 2023
8ARP	Crystal structure of DEAD-box protein Dbp2 in complex with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP2, MAGNESIUM ION, ... Authors: Song, Q.X, Rety, S, Xi, X.G. Deposit date: 2022-08-17 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Nonstructural N- and C-tails of Dbp2 confer the protein full helicase activities. J.Biol.Chem., 299, 2023
6N7P	S. cerevisiae spliceosomal E complex (UBC4) Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, Nuclear cap-binding protein complex subunit 1, Nuclear cap-binding protein subunit 2, ... Authors: Liu, S, Li, X, Zhou, Z.H, Zhao, R. Deposit date: 2018-11-27 Release date: 2019-09-18 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: A unified mechanism for intron and exon definition and back-splicing. Nature, 573, 2019
4E5G	Crystal structure of avian influenza virus PAn bound to compound 2 Descriptor: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, Polymerase protein PA, ... Authors: DuBois, R.M, Slavish, P.J, Webb, T.R, White, S.W. Deposit date: 2012-03-14 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.647 Å) Cite: Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. Plos Pathog., 8, 2012
4E5E	Crystal structure of avian influenza virus PAn Apo Descriptor: MANGANESE (II) ION, Polymerase protein PA, SULFATE ION Authors: DuBois, R.M, White, S.W. Deposit date: 2012-03-14 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.048 Å) Cite: Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. Plos Pathog., 8, 2012
4E5F	Crystal structure of avian influenza virus PAn bound to compound 1 Descriptor: 2-hydroxyisoquinoline-1,3(2H,4H)-dione, MANGANESE (II) ION, Polymerase protein PA, ... Authors: DuBois, R.M, Slavish, P.J, Webb, T.R, White, S.W. Deposit date: 2012-03-14 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.392 Å) Cite: Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. Plos Pathog., 8, 2012
4E5L	Crystal structure of avian influenza virus PAn bound to compound 6 Descriptor: 2,3-DIHYDROXY-BENZOIC ACID, MANGANESE (II) ION, Polymerase protein PA, ... Authors: DuBois, R.M, Slavish, P.J, Webb, T.R, White, S.W. Deposit date: 2012-03-14 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.469 Å) Cite: Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. Plos Pathog., 8, 2012
6AQR	SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin Descriptor: Polyubiquitin-C, SAGA-associated factor 11, SAGA-associated factor 73, ... Authors: Morrow, M.E, Morgan, M.T, Wolberger, C. Deposit date: 2017-08-21 Release date: 2018-07-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins. EMBO Rep., 19, 2018
7V1F	Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM and GTP) Descriptor: Core protein, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Jia, H, Gong, P. Deposit date: 2021-08-04 Release date: 2022-06-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct. J.Virol., 96, 2022
4E5H	Crystal structure of avian influenza virus PAn bound to compound 3 Descriptor: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, Polymerase protein PA, ... Authors: DuBois, R.M, Slavish, P.J, Webb, T.R, White, S.W. Deposit date: 2012-03-14 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.158 Å) Cite: Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. Plos Pathog., 8, 2012
4E5J	Crystal structure of avian influenza virus PAn bound to compound 5 Descriptor: 2-[3-(acetylamino)phenyl]-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, MANGANESE (II) ION, Polymerase protein PA, ... Authors: DuBois, R.M, Slavish, P.J, Webb, T.R, White, S.W. Deposit date: 2012-03-14 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. Plos Pathog., 8, 2012
4E5I	Crystal structure of avian influenza virus PAn bound to compound 4 Descriptor: 5-hydroxy-2-(1-methyl-1H-imidazol-4-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, MANGANESE (II) ION, Polymerase protein PA, ... Authors: DuBois, R.M, Slavish, P.J, Webb, T.R, White, S.W. Deposit date: 2012-03-14 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.944 Å) Cite: Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. Plos Pathog., 8, 2012

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