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PDB: 4 results

3WN7
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BU of 3wn7 by Molmil
Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor
Descriptor: ACETATE ION, Kelch-like ECH-associated protein 1, Peptide from Nuclear factor erythroid 2-related factor 2
Authors:Fukutomi, T, Takagi, K, Mizushima, T, Ohuchi, N, Yamamoto, M.
Deposit date:2013-12-05
Release date:2013-12-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1
Mol.Cell.Biol., 34, 2014
1X2R
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BU of 1x2r by Molmil
Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Descriptor: Kelch-like ECH-associated protein 1, Nuclear factor erythroid 2 related factor 2, SULFATE ION
Authors:Padmanabhan, B, Tong, K.I, Nakamura, Y, Ohta, T, Scharlock, M, Kobayashi, A, Ohtsuji, M, Kang, M.-I, Yamamoto, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-04-26
Release date:2006-03-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer
Mol.Cell, 21, 2006
2DYH
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BU of 2dyh by Molmil
Crystal structure of the Keap1 protein in complexed with the N-terminal region of the Nrf2 transcription factor
Descriptor: Kelch-like ECH-associated protein 1, Nrf2/Neh2 peptide from Nuclear factor erythroid 2-related factor 2, SULFATE ION
Authors:Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-09-14
Release date:2007-09-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
Mol.Cell.Biol., 27, 2007
7ECA
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BU of 7eca by Molmil
Crystal structure of the Keap1 complex with a peptide base on ETGE motif.
Descriptor: Kelch-like ECH-associated protein 1, LEU-ASP-GLU-GLU-THR-GLY-GLU-PHE-LEU-PRO, SULFATE ION
Authors:Cheng, L, Wang, C.
Deposit date:2021-03-11
Release date:2022-03-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.00006342 Å)
Cite:New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.
Life Sci, 282, 2021

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