1O5X
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![BU of 1o5x by Molmil](/molmil-images/mine/1o5x) | Plasmodium falciparum TIM complexed to 2-phosphoglycerate | Descriptor: | 2-PHOSPHOGLYCERIC ACID, 3-HYDROXYPYRUVIC ACID, PHOSPHITE ION, ... | Authors: | Parthasarathy, S, Eaazhisai, K, Balaram, H, Balaram, P, Murthy, M.R. | Deposit date: | 2003-10-06 | Release date: | 2004-01-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structure of Plasmodium falciparum Triose-phosphate Isomerase-2-Phosphoglycerate Complex at 1.1-A Resolution J.Biol.Chem., 278, 2003
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2VFD
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![BU of 2vfd by Molmil](/molmil-images/mine/2vfd) | Crystal structure of the F96S mutant of Plasmodium falciparum triosephosphate isomerase | Descriptor: | SULFATE ION, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-03 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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2VFF
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![BU of 2vff by Molmil](/molmil-images/mine/2vff) | Crystal structure of the F96H mutant of Plasmodium falciparum triosephosphate isomerase | Descriptor: | TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-04 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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3PVF
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![BU of 3pvf by Molmil](/molmil-images/mine/3pvf) | Structure of C126S mutant of Plasmodium falciparum triosephosphate isomerase complexed with PGA | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate isomerase | Authors: | Samanta, M, Banerjee, M, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2010-12-07 | Release date: | 2011-04-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis--distal effects on dimer stability. Febs J., 278, 2011
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5BMX
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![BU of 5bmx by Molmil](/molmil-images/mine/5bmx) | Crystal structure of T75N mutant of Triosephosphate isomerase from Plasmodium falciparum | Descriptor: | 1,2-ETHANEDIOL, SODIUM ION, SULFATE ION, ... | Authors: | Bandyopadhyay, D, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2015-05-24 | Release date: | 2015-07-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Probing the role of highly conserved residues in triosephosphate isomerase - analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzyme Febs J., 282, 2015
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5BNK
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![BU of 5bnk by Molmil](/molmil-images/mine/5bnk) | Crystal structure of T75C mutant of Triosephosphate isomerase from Plasmodium falciparum | Descriptor: | 1,2-ETHANEDIOL, SODIUM ION, Triosephosphate isomerase | Authors: | Bandyopadhyay, D, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2015-05-26 | Release date: | 2015-07-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Probing the role of highly conserved residues in triosephosphate isomerase - analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzyme Febs J., 282, 2015
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1VGA
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![BU of 1vga by Molmil](/molmil-images/mine/1vga) | Structures of unligated and inhibitor complexes of W168F mutant of Triosephosphate Isomerase from Plasmodium falciparum | Descriptor: | Triosephosphate isomerase | Authors: | Eaazhisai, K, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2004-04-23 | Release date: | 2004-10-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of Unliganded and Inhibitor Complexes of W168F, a Loop6 Hinge Mutant of Plasmodium falciparum Triosephosphate Isomerase: Observation of an Intermediate Position of Loop6 J.Mol.Biol., 343, 2004
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4ZZ9
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![BU of 4zz9 by Molmil](/molmil-images/mine/4zz9) | Crystal structure of T75S mutant of Triosephosphate isomerase from Plasmodium falciparum | Descriptor: | 1,2-ETHANEDIOL, SODIUM ION, Triosephosphate isomerase | Authors: | Bandyopadhyay, D, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2015-05-22 | Release date: | 2015-07-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Probing the role of highly conserved residues in triosephosphate isomerase - analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzyme Febs J., 282, 2015
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4YWI
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![BU of 4ywi by Molmil](/molmil-images/mine/4ywi) | F96S/L167V Double mutant of Plasmodium Falciparum Triosephosphate Isomerase | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Triosephosphate isomerase | Authors: | Pareek, V, Balaram, P, Murthy, M.R.N. | Deposit date: | 2015-03-20 | Release date: | 2016-02-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial Enzyme Chembiochem, 17, 2016
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5BMW
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![BU of 5bmw by Molmil](/molmil-images/mine/5bmw) | Crystal structure of T75V mutant of Triosephosphate isomerase from Plasmodium falciparum | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Bandyopadhyay, D, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2015-05-23 | Release date: | 2015-07-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Probing the role of highly conserved residues in triosephosphate isomerase - analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzyme Febs J., 282, 2015
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4YXG
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![BU of 4yxg by Molmil](/molmil-images/mine/4yxg) | |
1LYX
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![BU of 1lyx by Molmil](/molmil-images/mine/1lyx) | Plasmodium Falciparum Triosephosphate Isomerase (PfTIM)-Phosphoglycolate complex | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, Triosephosphate Isomerase | Authors: | Parthasarathy, S, Balaram, H, Balaram, P, Murthy, M.R. | Deposit date: | 2002-06-10 | Release date: | 2003-01-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Plasmodium falciparum triosephosphate isomerase-phosphoglycolate complex in two crystal forms: characterization of catalytic loop open and closed conformations in the ligand-bound state Biochemistry, 41, 2002
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3PY2
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![BU of 3py2 by Molmil](/molmil-images/mine/3py2) | Structure of C126S mutant of Plasmodium falciparum triosephosphate isomerase | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Triosephosphate isomerase | Authors: | Samanta, M, Banerjee, M, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2010-12-11 | Release date: | 2011-04-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis--distal effects on dimer stability. Febs J., 278, 2011
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2VFG
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![BU of 2vfg by Molmil](/molmil-images/mine/2vfg) | Crystal structure of the F96H mutant of Plasmodium falciparum triosephosphate isomerase with 3-phosphoglycerate bound at the dimer interface | Descriptor: | 3-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-04 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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3PSW
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![BU of 3psw by Molmil](/molmil-images/mine/3psw) | Structure of E97Q mutant of TIM from Plasmodium falciparum | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Triosephosphate isomerase | Authors: | Samanta, M, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2010-12-02 | Release date: | 2011-10-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Revisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residue Chembiochem, 12, 2011
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2VFH
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![BU of 2vfh by Molmil](/molmil-images/mine/2vfh) | Crystal structure of the F96W mutant of Plasmodium falciparum triosephosphate isomerase complexed with 3-phosphoglycerate | Descriptor: | 3-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-04 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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3PSV
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![BU of 3psv by Molmil](/molmil-images/mine/3psv) | Structure of E97D mutant of TIM from Plasmodium falciparum | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Triosephosphate isomerase | Authors: | Samanta, M, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2010-12-02 | Release date: | 2011-10-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Revisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residue Chembiochem, 12, 2011
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5GZP
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![BU of 5gzp by Molmil](/molmil-images/mine/5gzp) | |
3PWA
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![BU of 3pwa by Molmil](/molmil-images/mine/3pwa) | Structure of C126A mutant of Plasmodium falciparum triosephosphate isomerase | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | Authors: | Samanta, M, Banerjee, M, Murthy, M.R.N, Balaram, H, Balaram, P. | Deposit date: | 2010-12-08 | Release date: | 2011-04-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis--distal effects on dimer stability. Febs J., 278, 2011
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4Z0J
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![BU of 4z0j by Molmil](/molmil-images/mine/4z0j) | F96S/S73A Double mutant of Plasmodium Falciparum Triosephosphate Isomerase | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Triosephosphate isomerase | Authors: | Pareek, V, Balaram, P, Murthy, M.R.N. | Deposit date: | 2015-03-26 | Release date: | 2016-02-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial Enzyme Chembiochem, 17, 2016
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5GV4
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![BU of 5gv4 by Molmil](/molmil-images/mine/5gv4) | |
1YDV
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![BU of 1ydv by Molmil](/molmil-images/mine/1ydv) | TRIOSEPHOSPHATE ISOMERASE (TIM) | Descriptor: | TRIOSEPHOSPHATE ISOMERASE | Authors: | Velankar, S.S, Murthy, M.R.N. | Deposit date: | 1997-04-24 | Release date: | 1997-10-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design. Structure, 5, 1997
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2VFE
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![BU of 2vfe by Molmil](/molmil-images/mine/2vfe) | Crystal structure of F96S mutant of Plasmodium falciparum triosephosphate isomerase with 3- phosphoglycerate bound at the dimer interface | Descriptor: | 3-PHOSPHOGLYCERIC ACID, GLYCEROL, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-03 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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2VFI
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![BU of 2vfi by Molmil](/molmil-images/mine/2vfi) | Crystal structure of the Plasmodium falciparum triosephosphate isomerase in the loop closed state with 3-phosphoglycerate bound at the active site and interface | Descriptor: | 3-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE | Authors: | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | Deposit date: | 2007-11-04 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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4Z0S
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![BU of 4z0s by Molmil](/molmil-images/mine/4z0s) | |