1K64
 
 | | NMR Structue of alpha-conotoxin EI | | Descriptor: | alpha-conotoxin EI | | Authors: | Park, K.H, Suk, J.E, Jacobsen, R, Gray, W.R, McIntosh, J.M, Han, K.H. | | Deposit date: | 2001-10-15 | | Release date: | 2003-09-09 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor
J.BIOL.CHEM., 276, 2001
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9BAF
 | | Solution NMR structure of conofurin-Delta | | Descriptor: | Alpha-conotoxin LvIA | | Authors: | Harvey, P.J, Craik, D.J, Hone, A.J, McIntosh, J.M. | | Deposit date: | 2024-04-04 | | Release date: | 2024-07-03 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors.
J.Med.Chem., 67, 2024
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7EDK
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6OTA
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4TTL
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6CGX
 | | Backbone cyclised conotoxin Vc1.1 mutant - D11A, E14A | | Descriptor: | Alpha-conotoxin Vc1A | | Authors: | Clark, R.J. | | Deposit date: | 2018-02-21 | | Release date: | 2018-05-23 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by alpha-Conotoxin Vc1.1.
ACS Chem. Biol., 13, 2018
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1IEN
 | | SOLUTION STRUCTURE OF TIA | | Descriptor: | PROTEIN TIA | | Authors: | Sharpe, I.A, Gehrmann, J, Loughnan, M.L, Thomas, L, Adams, D.A, Atkins, A, Palant, E, Craik, D.J, Adams, D.J, Alewood, P.F, Lewis, R.J. | | Deposit date: | 2001-04-10 | | Release date: | 2002-04-03 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.
Nat.Neurosci., 4, 2001
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1UL2
 | | Solution Conformation of alpha-Conotoxin GIC | | Descriptor: | alpha-conotoxin GIC | | Authors: | Chi, S.-W, Kim, D.-H, Olivera, B.M, McIntosh, J.M, Han, K.-H. | | Deposit date: | 2003-09-06 | | Release date: | 2004-07-20 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors
Biochem.J., 380, 2004
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1DG2
 | | SOLUTION CONFORMATION OF A-CONOTOXIN AUIB | | Descriptor: | A-CONOTOXIN AUIB | | Authors: | Cho, J.-H, Mok, K.H, Olivera, B.M, McIntosh, J.M, Park, K.-H, Han, K.-H. | | Deposit date: | 1999-11-23 | | Release date: | 2000-02-25 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist.
J.Biol.Chem., 275, 2000
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5UG3
 | | NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID MUTANT A10V | | Descriptor: | Alpha-conotoxin GID | | Authors: | Hussein, A.K, Leffler, A.E, Zebroski, H.A, Powell, S.R, Kuryatov, A, Filipenko, P, Gorson, J, Heizmann, A, Lyskov, S, Nicke, A, Lindstrom, J, Rudy, B, Bonneau, R, Holford, M, Poget, S.F. | | Deposit date: | 2017-01-06 | | Release date: | 2017-09-06 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UG5
 | | NMR SOLUTION STRUCTURE OF THE ALPHA-CONOTOXIN GID MUTANT V13Y | | Descriptor: | Alpha-conotoxin GID | | Authors: | Hussein, A, Leffler, A.E, Kuryatov, A, Zebroski, H.A, Powell, S.R, Filipenko, P, Gorson, J, Heizmann, A, Lyskov, S, Nicke, A, Lindstrom, J, Rudy, B, Bonneau, R, Holford, M, Poget, S.F. | | Deposit date: | 2017-01-06 | | Release date: | 2017-09-06 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1A0M
 | | 1.1 ANGSTROM CRYSTAL STRUCTURE OF A-CONOTOXIN [TYR15]-EPI | | Descriptor: | ALPHA-CONOTOXIN [TYR15]-EPI | | Authors: | Hu, S.-H, Loughnan, M, Miller, R, Weeks, C.M, Blessing, R.H, Alewood, P.F, Lewis, R.J, Martin, J.L. | | Deposit date: | 1997-12-03 | | Release date: | 1999-01-13 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods.
Biochemistry, 37, 1998
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1AKG
 | | ALPHA-CONOTOXIN PNIB FROM CONUS PENNACEUS | | Descriptor: | ALPHA-CONOTOXIN PNIB | | Authors: | Hu, S.-H, Martin, J.L. | | Deposit date: | 1997-05-18 | | Release date: | 1998-05-20 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Crystal structure at 1.1 A resolution of alpha-conotoxin PnIB: comparison with alpha-conotoxins PnIA and GI.
Biochemistry, 36, 1997
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2GCZ
 | | Solution Structure of alpha-Conotoxin OmIA | | Descriptor: | Alpha-conotoxin OmIA | | Authors: | Chi, S.-W, Kim, D.-H, Olivera, B.M, McIntosh, J.M, Han, K.-H. | | Deposit date: | 2006-03-15 | | Release date: | 2006-07-25 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes
Biochem.Biophys.Res.Commun., 345, 2006
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2H8S
 | | Solution structure of alpha-conotoxin Vc1.1 | | Descriptor: | Alpha-conotoxin Vc1A | | Authors: | Clark, R.J, Fischer, H, Nevin, S.T, Adams, D.J, Craik, D.J. | | Deposit date: | 2006-06-07 | | Release date: | 2006-06-27 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | The Synthesis, Structural Characterization, and Receptor Specificity of the {alpha}-Conotoxin Vc1.1.
J.Biol.Chem., 281, 2006
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1ZLC
 | | Solution Conformation of alpha-conotoxin PIA | | Descriptor: | Alpha-conotoxin PIA | | Authors: | Chi, S.-W, Lee, S.-H, Kim, D.-H, Kim, J.-S, Olivera, B.M, McIntosh, J.M, Han, K.-H. | | Deposit date: | 2005-05-05 | | Release date: | 2006-05-02 | | Last modified: | 2024-10-23 | | Method: | SOLUTION NMR | | Cite: | Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors
Biochem.Biophys.Res.Commun., 338, 2005
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2AJW
 | | Structure of the cyclic conotoxin MII-6 | | Descriptor: | Alpha-conotoxin MII | | Authors: | Clark, R.J, Fischer, H, Dempster, L, Daly, N.L, Rosengren, K.J, Nevin, S.T, Meunier, F.A, Adams, D.J, Craik, D.J. | | Deposit date: | 2005-08-02 | | Release date: | 2005-09-06 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the {alpha}-conotoxin MII.
Proc.Natl.Acad.Sci.USA, 102, 2005
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2AK0
 | | Structure of cyclic conotoxin MII-7 | | Descriptor: | Alpha-conotoxin MII | | Authors: | Clark, R.J, Fischer, H, Dempster, L, Daly, N.L, Rosengren, K.J, Nevin, S.T, Meunier, F.A, Adams, D.J, Craik, D.J. | | Deposit date: | 2005-08-02 | | Release date: | 2005-09-06 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the {alpha}-conotoxin MII.
Proc.Natl.Acad.Sci.USA, 102, 2005
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1M2C
 | | THREE-DIMENSIONAL STRUCTURE OF ALPHA-CONOTOXIN MII, NMR, 14 STRUCTURES | | Descriptor: | ALPHA-CONOTOXIN MII | | Authors: | Shon, K.J, Koerber, S.C, Rivier, J.E, Olivera, B.M, Mcintosh, J.M. | | Deposit date: | 1997-09-15 | | Release date: | 1998-12-09 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors.
J.Biol.Chem., 271, 1996
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1MXP
 | | Solution structure of the ribbon disulfide bond isomer of alpha-conotoxin AuIB | | Descriptor: | alpha-conotoxin AuIB | | Authors: | Dutton, J.L, Bansal, P.S, Hogg, R.C, Adams, D.J, Alewood, P.F, Craik, D.J. | | Deposit date: | 2002-10-03 | | Release date: | 2002-12-30 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | A New Level of Conotoxin Diversity, a Non-native Disulfide Bond Connectivity in alpha -Conotoxin AuIB Reduces Structural Definition but Increases Biological Activity.
J.Biol.Chem., 277, 2002
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1MTQ
 | | THREE-DIMENSIONAL SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID BY NMR SPECTROSCOPY | | Descriptor: | alpha-conotoxin GID | | Authors: | Nicke, A, Loughnan, M.L, Millard, E.L, Alewood, P.F, Adams, D.J, Daly, N.L, Craik, D.J, Lewis, R.J. | | Deposit date: | 2002-09-22 | | Release date: | 2003-02-11 | | Last modified: | 2025-03-26 | | Method: | SOLUTION NMR | | Cite: | Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence
J.BIOL.CHEM., 278, 2003
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1MXN
 | | Solution structure of alpha-conotoxin AuIB | | Descriptor: | alpha-conotoxin AuIB | | Authors: | Dutton, J.L, Bansal, P.S, Hogg, R.C, Adams, D.J, Alewood, P.F, Craik, D.J. | | Deposit date: | 2002-10-02 | | Release date: | 2002-12-30 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | A New Level of Conotoxin Diversity, a Non-native Disulfide Bond Connectivity in alpha -Conotoxin AuIB Reduces Structural Definition but Increases Biological Activity.
J.Biol.Chem., 277, 2002
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1MII
 | | SOLUTION STRUCTURE OF ALPHA-CONOTOXIN MII | | Descriptor: | PROTEIN (ALPHA CONOTOXIN MII) | | Authors: | Hill, J.M, Oomen, C.J, Miranda, L.P, Bingham, J.P, Alewood, P.F, Craik, D.J. | | Deposit date: | 1998-10-05 | | Release date: | 1998-10-21 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity.
Biochemistry, 37, 1998
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7KNN
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7N24
 | | NMR structure of native EpI | | Descriptor: | Alpha-conotoxin EpI | | Authors: | Conibear, A.C, Rosengren, K.J, Lee, H.S. | | Deposit date: | 2021-05-28 | | Release date: | 2021-11-17 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
Rsc Med Chem, 12, 2021
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