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PDB: 11 results
6VH6
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BU of 6vh6 by Molmil
Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragment
Descriptor: 4-hydroxy-6-methyl-2H-1-benzopyran-2-one, Epstein-Barr nuclear antigen 1
Authors:Messick, T.E, Lieberman, P.M.
Deposit date:2020-01-09
Release date:2020-05-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Biophysical Screens Identify Fragments That Bind to the Viral DNA-Binding Proteins EBNA1 and LANA.
Molecules, 25, 2020
7U1T
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BU of 7u1t by Molmil
EBNA1 DNA binding domain (401-641) binds to half Dyad Symmetry element
Descriptor: DNA (59-MER), Epstein-Barr nuclear antigen 1
Authors:Mei, Y, Lieberman, P.
Deposit date:2022-02-22
Release date:2023-02-22
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:EBNA1 DNA binding domain (401-641) binds to half Dyad Symmetry element
To Be Published
8DLF
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BU of 8dlf by Molmil
EBNA1 DNA binding domain (DBD) (458-617)+2 repeats of family repeat (FR) region
Descriptor: 2XFR DNA (56-MER), Epstein-Barr nuclear antigen 1
Authors:Mei, Y, Lieberman, P.M, Murakami, K.
Deposit date:2022-07-07
Release date:2023-05-17
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus oriP.
J.Virol., 96, 2022
6PW2
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BU of 6pw2 by Molmil
Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication
Descriptor: DNA (62-MER), DNA (62-MER) complementary DNA strand, Epstein-Barr nuclear antigen 1
Authors:Messick, T.E, Malecka, K.A, Lieberman, P.M.
Deposit date:2019-07-22
Release date:2019-08-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication.
J.Virol., 93, 2019
5WMF
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BU of 5wmf by Molmil
Crystal structure of the Hexameric Ring of Epstein-Barr Virus Nuclear Antigen-1, EBNA1
Descriptor: Epstein-Barr nuclear antigen 1
Authors:Messick, T.E.
Deposit date:2017-07-28
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance.
J. Virol., 91, 2017
1VHI
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BU of 1vhi by Molmil
EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1 DNA-BINDING DOMAIN, RESIDUES 470-607
Descriptor: EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1
Authors:Bochkarev, A, Barwell, J, Pfuetzner, R, Furey, W, Edwards, A, Frappier, L.
Deposit date:1996-10-05
Release date:1996-12-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1.
Cell(Cambridge,Mass.), 83, 1995
1B3T
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BU of 1b3t by Molmil
EBNA-1 NUCLEAR PROTEIN/DNA COMPLEX
Descriptor: DNA (5'-D(*GP*GP*GP*AP*AP*GP*CP*AP*TP*AP*TP*GP*CP*TP*TP*CP*CP*C)-3'), PROTEIN (NUCLEAR PROTEIN EBNA1)
Authors:Bochkarev, A, Bochkareva, E, Edwards, A, Frappier, L.
Deposit date:1998-12-14
Release date:1998-12-15
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 2.2 A structure of a permanganate-sensitive DNA site bound by the Epstein-Barr virus origin binding protein, EBNA1.
J.Mol.Biol., 284, 1998
5T7X
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BU of 5t7x by Molmil
Crystal structure of HHV-4 EBNA1 DNA binding domain (patient-derived, nasopharyngeal carcinoma) bound to DNA
Descriptor: DNA (5'-D(*GP*GP*AP*TP*AP*GP*CP*CP*TP*AP*TP*GP*CP*TP*AP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*TP*AP*GP*CP*AP*TP*AP*GP*GP*CP*TP*AP*TP*CP*C)-3'), Epstein-Barr nuclear antigen 1
Authors:Malecka, K.A, Messick, T.E, Lieberman, P.M.
Deposit date:2016-09-06
Release date:2017-07-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.
Oncotarget, 8, 2017
6NPM
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BU of 6npm by Molmil
Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments
Descriptor: 5-(phenylethynyl)pyridine-3-carboxylic acid, Epstein-Barr nuclear antigen 1
Authors:Messick, T.E.
Deposit date:2019-01-17
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
Sci Transl Med, 11, 2019
6NPI
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BU of 6npi by Molmil
Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments
Descriptor: ({2-[(4-bromo-5-methyl-1,2-oxazol-3-yl)amino]-2-oxoethyl}sulfanyl)acetic acid, 2-pyrrol-1-ylbenzoic acid, Epstein-Barr nuclear antigen 1
Authors:Messick, T.E.
Deposit date:2019-01-17
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
Sci Transl Med, 11, 2019
6NPP
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BU of 6npp by Molmil
Crystal structure of Epstein-Barr Virus Nuclear Antigen-1, EBNA1, bound to fragments
Descriptor: 3-(phenylethynyl)-2-(1H-pyrrol-1-yl)benzoic acid, EBNA1, Epstein-Barr nuclear antigen 1
Authors:Messick, T.E.
Deposit date:2019-01-18
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth.
Sci Transl Med, 11, 2019

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