8GIY
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![BU of 8giy by Molmil](/molmil-images/mine/8giy) | E. coli clamp loader with closed clamp | Descriptor: | Beta sliding clamp, DNA polymerase III subunit delta, DNA polymerase III subunit delta', ... | Authors: | Oakley, A.J, Xu, Z.-Q, Dixon, N.E. | Deposit date: | 2023-03-14 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural characterisation of the complete cycle of sliding clamp loading in E. coli To Be Published
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8GJ2
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8GJ0
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5FVE
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![BU of 5fve by Molmil](/molmil-images/mine/5fve) | |
5FKV
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![BU of 5fkv by Molmil](/molmil-images/mine/5fkv) | cryo-EM structure of the E. coli replicative DNA polymerase complex bound to DNA (DNA polymerase III alpha, beta, epsilon, tau complex) | Descriptor: | DNA POLYMERASE III BETA, DNA POLYMERASE III EPSILON, DNA POLYMERASE III SUBUNIT ALPHA, ... | Authors: | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | Deposit date: | 2015-10-20 | Release date: | 2015-11-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (8.04 Å) | Cite: | cryo-EM structures of theE. colireplicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease andtau. Elife, 4, 2015
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5FKW
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![BU of 5fkw by Molmil](/molmil-images/mine/5fkw) | cryo-EM structure of the E. coli replicative DNA polymerase complex bound to DNA (DNA polymerase III alpha, beta, epsilon) | Descriptor: | DNA POLYMERASE III ALPHA, DNA POLYMERASE III BETA, DNA POLYMERASE III EPSILON, ... | Authors: | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | Deposit date: | 2015-10-20 | Release date: | 2015-11-25 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7.3 Å) | Cite: | cryo-EM structures of theE. colireplicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease andtau. Elife, 4, 2015
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5FXT
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5G4Q
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![BU of 5g4q by Molmil](/molmil-images/mine/5g4q) | H.pylori Beta clamp in complex with 5-chloroisatin | Descriptor: | 5-chloro-1H-indole-2,3-dione, DNA POLYMERASE III SUBUNIT BETA | Authors: | Pandey, P, Gourinath, S. | Deposit date: | 2016-05-16 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Screening of E. coli beta-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization. Antibiotics (Basel), 7, 2018
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5G48
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![BU of 5g48 by Molmil](/molmil-images/mine/5g48) | H.pylori Beta clamp in complex with Diflunisal | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, DNA POLYMERASE III SUBUNIT BETA | Authors: | Pandey, P, Gourinath, S. | Deposit date: | 2016-05-06 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Targeting the beta-clamp in Helicobacter pylori with FDA-approved drugs reveals micromolar inhibition by diflunisal. FEBS Lett., 591, 2017
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4N96
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![BU of 4n96 by Molmil](/molmil-images/mine/4n96) | E. coli sliding clamp in complex with 6-nitroindazole | Descriptor: | 6-NITROINDAZOLE, CALCIUM ION, CHLORIDE ION, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-10-19 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
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4RKI
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4TR7
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3Q4J
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![BU of 3q4j by Molmil](/molmil-images/mine/3q4j) | Structure of a small peptide ligand bound to E.coli DNA sliding clamp | Descriptor: | DNA polymerase III subunit beta, peptide ligand | Authors: | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | Deposit date: | 2010-12-23 | Release date: | 2011-12-28 | Last modified: | 2013-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J.Med.Chem., 54, 2011
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4TR8
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![BU of 4tr8 by Molmil](/molmil-images/mine/4tr8) | Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa | Descriptor: | DNA polymerase III subunit beta, SODIUM ION | Authors: | Olieric, V, Burnouf, D, Ennifar, E, Wolff, P. | Deposit date: | 2014-06-15 | Release date: | 2014-09-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins. J.Med.Chem., 57, 2014
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3Q4K
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![BU of 3q4k by Molmil](/molmil-images/mine/3q4k) | Structure of a small peptide ligand bound to E.coli DNA sliding clamp | Descriptor: | DNA polymerase III subunit beta, peptide ligand | Authors: | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | Deposit date: | 2010-12-23 | Release date: | 2011-12-28 | Last modified: | 2013-03-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J.Med.Chem., 54, 2011
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4TR6
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![BU of 4tr6 by Molmil](/molmil-images/mine/4tr6) | Crystal structure of DNA polymerase sliding clamp from Bacillus subtilis | Descriptor: | DNA polymerase III subunit beta, SODIUM ION | Authors: | Burnouf, D, Olieric, V, Ennifar, E, Wolff, P. | Deposit date: | 2014-06-14 | Release date: | 2014-09-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins. J.Med.Chem., 57, 2014
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4N94
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![BU of 4n94 by Molmil](/molmil-images/mine/4n94) | E. coli sliding clamp in complex with 3,4-difluorobenzamide | Descriptor: | 1,2-ETHANEDIOL, 3,4-difluorobenzamide, CALCIUM ION, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-10-19 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
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3PWE
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![BU of 3pwe by Molmil](/molmil-images/mine/3pwe) | Crystal structure of the E. coli beta clamp mutant R103C, I305C, C260S, C333S at 2.2A resolution | Descriptor: | DNA polymerase III subunit beta | Authors: | Marzahn, M.R, Robbins, A.H, McKenna, R, Bloom, L.B. | Deposit date: | 2010-12-08 | Release date: | 2011-10-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | The E. coli clamp loader can actively pry open the beta-sliding clamp J.Biol.Chem., 286, 2011
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3P16
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![BU of 3p16 by Molmil](/molmil-images/mine/3p16) | Crystal structure of DNA polymerase III sliding clamp | Descriptor: | DNA polymerase III subunit beta | Authors: | Gui, W.J, Lin, S.Q, Chen, Y.Y, Zhang, X.E, Bi, L.J, Jiang, T. | Deposit date: | 2010-09-30 | Release date: | 2011-08-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Crystal structure of DNA polymerase III beta sliding clamp from Mycobacterium tuberculosis. Biochem.Biophys.Res.Commun., 405, 2011
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4TSZ
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![BU of 4tsz by Molmil](/molmil-images/mine/4tsz) | Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa with ligand | Descriptor: | ACE-GLN-ALC-ASP-LEU-ZCL peptide, DNA polymerase III subunit beta | Authors: | Olieric, V, Burnouf, D, Ennifar, E, Wolff, P. | Deposit date: | 2014-06-19 | Release date: | 2014-09-10 | Last modified: | 2016-12-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins. J.Med.Chem., 57, 2014
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4S3I
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4N97
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![BU of 4n97 by Molmil](/molmil-images/mine/4n97) | E. coli sliding clamp in complex with 5-nitroindole | Descriptor: | 5-nitro-1H-indole, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-10-19 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
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4N99
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![BU of 4n99 by Molmil](/molmil-images/mine/4n99) | E. coli sliding clamp in complex with 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-7-carboxylic acid | Descriptor: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-7-carboxylic acid, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-10-19 | Release date: | 2013-11-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
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4TRT
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3QSB
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![BU of 3qsb by Molmil](/molmil-images/mine/3qsb) | Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile | Descriptor: | (1R,5R)-5-{(1Z)-N-[(4'-fluorobiphenyl-4-yl)methoxy]butanimidoyl}-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile, DNA polymerase III subunit beta | Authors: | Wijffels, G, Johnson, W.M, Oakley, A.J, Turner, K, Epa, V.C, Briscoe, S.J, Polley, M, Liepa, A.J, Hofmann, A, Buchardt, J, Christensen, C, Prosselkov, P, Dalrymple, B.P, Alewood, P.F, Jennings, P.A, Dixon, N.E, Winkler, D.A. | Deposit date: | 2011-02-20 | Release date: | 2011-06-08 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Binding inhibitors of the bacterial sliding clamp by design J.Med.Chem., 54, 2011
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