1A48
 
 | | SAICAR SYNTHASE | | Descriptor: | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE, SULFATE ION | | Authors: | Levdikov, V.M, Melik-Adamyan, W.R, Lamzin, V.S, Wilson, K.S. | | Deposit date: | 1998-02-12 | | Release date: | 1999-03-30 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis.
Structure, 6, 1998
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3KRE
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1KUT
 | | Structural Genomics, Protein TM1243, (SAICAR synthetase) | | Descriptor: | Phosphoribosylaminoimidazole-succinocarboxamide synthase | | Authors: | Zhang, R, Skarina, T, Beasley, S, Edwards, A, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2002-01-22 | | Release date: | 2002-08-14 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer.
Acta Crystallogr.,Sect.F, 62, 2006
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1OBG
 | | SAICAR-synthase complexed with ATP | | Descriptor: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, PHOSPHORIBOSYLAMIDOIMIDAZOLE- SUCCINOCARBOXAMIDE SYNTHASE, ... | | Authors: | Antonyuk, S.V, Grebenko, A.I, Levdikov, V.M, Urusova, D.V, Melik-Adamyan, W.R, Lamzin, V.S, Wilson, K. | | Deposit date: | 2003-01-30 | | Release date: | 2003-03-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | X-Ray Structure of Saicar-Synthase Complexed with ATP
Kristallografiya, 46, 2001
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4FGR
 | | X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with ADP and Mg2+ | | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Fung, L.W.-M, Johnson, M.E, Abad-Zapatero, C, Wolf, N.W. | | Deposit date: | 2012-06-04 | | Release date: | 2013-06-05 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.597 Å) | | Cite: |
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4FE2
 | | X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+ | | Descriptor: | 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Wolf, N, Abad-Zapatero, C, Johnson, M.E, Fung, L.M.-W. | | Deposit date: | 2012-05-29 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.288 Å) | | Cite: | Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp.
Acta Crystallogr.,Sect.D, 70, 2014
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1OBD
 | | SAICAR-synthase complexed with ATP | | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Antonyuk, S.V, Grebenko, A.I, Levdikov, V.M, Urusova, D.V, Melik-Adamyan, W.R, Lamzin, V.S, Wilson, K. | | Deposit date: | 2003-01-30 | | Release date: | 2003-03-06 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | X-Ray Structure of Saicar-Synthase Complexed with ATP
Kristallografiya, 46, 2001
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3U55
 | | Crystal structure (Type-2) of SAICAR synthetase from Pyrococcus horikoshii OT3 | | Descriptor: | ACETATE ION, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SULFATE ION | | Authors: | Manjunath, K, Kanaujia, S.P, Kanagaraj, S, Jeyakanthan, J, Sekar, K. | | Deposit date: | 2011-10-11 | | Release date: | 2012-10-17 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of SAICAR synthetase from Pyrococcus horikoshii OT3: insights into thermal stability
Int.J.Biol.Macromol., 53, 2013
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3R9R
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3U54
 | | Crystal structure (Type-1) of SAICAR synthetase from Pyrococcus horikoshii OT3 | | Descriptor: | 1,4-BUTANEDIOL, ACETATE ION, CADMIUM ION, ... | | Authors: | Manjunath, K, Kanaujia, S.P, Kanagaraj, S, Jeyakanthan, J, Sekar, K. | | Deposit date: | 2011-10-11 | | Release date: | 2012-10-17 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure of SAICAR synthetase from Pyrococcus horikoshii OT3: insights into thermal stability
Int.J.Biol.Macromol., 53, 2013
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3NUA
 | | Crystal Structure of Phosphoribosylaminoimidazole-Succinocarboxamide Synthase from Clostridium perfringens | | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, CITRIC ACID, ... | | Authors: | Kim, Y, Mulligan, R, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2010-07-06 | | Release date: | 2010-08-25 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal Structure of Phosphoribosylaminoimidazole-Succinocarboxamide Synthase from Clostridium perfringens
To be Published
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2Z02
 | | Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase wit ATP from Methanocaldococcus jannaschii | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, Phosphoribosylaminoimidazole-succinocarboxamide synthase, ... | | Authors: | Kanagawa, M, Baba, S, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-06 | | Release date: | 2007-11-06 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase from Methanocaldococcus jannaschii
To be Published
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2YZL
 | | Crystal structure of phosphoribosylaminoimidazole-succinocarboxamide synthase with ADP from Methanocaldococcus jannaschii | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SULFATE ION | | Authors: | Kanagawa, M, Baba, S, Fukui, K, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-06 | | Release date: | 2007-11-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of phosphoribosylaminoimidazole-succinocarboxamide synthase with ADP from Methanocaldococcus jannaschii
To be Published
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2YWV
 | | Crystal structure of SAICAR synthetase from Geobacillus kaustophilus | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoribosylaminoimidazole succinocarboxamide synthetase, ... | | Authors: | Kanagawa, M, Baba, S, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-23 | | Release date: | 2007-10-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of SAICAR synthetase from Geobacillus kaustophilus
To be Published
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2GQR
 | | SAICAR Synthetase Complexed with ADP-Mg2+ | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoribosylaminoimidazole-succinocarboxamide synthase | | Authors: | Ginder, N.D, Honzatko, R.B. | | Deposit date: | 2006-04-21 | | Release date: | 2006-05-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Nucleotide Complexes of Escherichia coli Phosphoribosylaminoimidazole Succinocarboxamide Synthetase.
J.Biol.Chem., 281, 2006
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2CNQ
 | | Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with ADP, AICAR, succinate | | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ... | | Authors: | Urusova, D.V, Antonyuk, S.V, Grebenko, A.I, Levdikov, V.M, Barynin, V.V, Popov, A.N, Lamzin, V.S, Melik-Adamyan, W.R. | | Deposit date: | 2006-05-23 | | Release date: | 2006-06-08 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | Saicar Synthase: Substrate Recognition, Conformational Flexibility and Catalysis.
To be Published
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2CNV
 | | SAICAR-synthase from Saccharomyces cerevisiae complexed SAICAR | | Descriptor: | ASPARTIC ACID, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID, PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE, ... | | Authors: | Urusova, D.V, Antonyuk, S.V, Grebenko, A.I, Levdikov, V.M, Barynin, V.V, Popov, A.N, Lamzin, V.S, Melik-Adamyan, V.R. | | Deposit date: | 2006-05-24 | | Release date: | 2006-06-08 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-Ray Diffraction Study of the Complex of the Enzyme Saicar Synthase with the Reaction Product
Crystallogr.Rep.(Transl. Kristallografiya), 51, 2006
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2CNU
 | | Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with aspartic acid | | Descriptor: | ASPARTIC ACID, PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE, SULFATE ION | | Authors: | Urusova, D.V, Antonyuk, S.V, Grebenko, A.I, Levdikov, V.M, Barynin, V.V, Popov, A.N, Lamzin, V.S, Melik-Adamyan, W.R. | | Deposit date: | 2006-05-24 | | Release date: | 2006-06-07 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | Saicar Synthase: Substrate Recognition, Conformational Flexibility and Catalysis.
To be Published
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2GQS
 | | SAICAR Synthetase Complexed with CAIR-Mg2+ and ADP | | Descriptor: | 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, ADENOSINE-5'-DIPHOSPHATE, FORMIC ACID, ... | | Authors: | Ginder, N.D, Honzatko, R.B. | | Deposit date: | 2006-04-21 | | Release date: | 2006-05-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Nucleotide Complexes of Escherichia coli Phosphoribosylaminoimidazole Succinocarboxamide Synthetase.
J.Biol.Chem., 281, 2006
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6YY6
 | | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 4-azanyl-6-(1-ethylpyrazol-4-yl)pyrimidine-5-carbonitrile, Phosphoribosylaminoimidazole-succinocarboxamide synthase, ... | | Authors: | Thomas, S.E, Charoensutthivarakul, S, Coyne, A.G, Abell, C, Blundell, T.L. | | Deposit date: | 2020-05-04 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.499 Å) | | Cite: | Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Acs Infect Dis., 8, 2022
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6YYC
 | | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 5-chloranyl-6-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]pyrimidin-4-amine, Phosphoribosylaminoimidazole-succinocarboxamide synthase, ... | | Authors: | Thomas, S.E, Charoensutthivarakul, S, Coyne, A.G, Abell, C, Blundell, T.L. | | Deposit date: | 2020-05-04 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.274 Å) | | Cite: | Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Acs Infect Dis., 8, 2022
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6YY9
 | | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 4-azanyl-6-[1-(pyridin-3-ylmethyl)pyrazol-4-yl]pyrimidine-5-carbonitrile, Phosphoribosylaminoimidazole-succinocarboxamide synthase, ... | | Authors: | Thomas, S.E, Charoensutthivarakul, S, Coyne, A.G, Abell, C, Blundell, T.L. | | Deposit date: | 2020-05-04 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.413 Å) | | Cite: | Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Acs Infect Dis., 8, 2022
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6YYA
 | | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 4-azanyl-6-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]pyrimidine-5-carbonitrile, Phosphoribosylaminoimidazole-succinocarboxamide synthase, ... | | Authors: | Thomas, S.E, Charoensutthivarakul, S, Coyne, A.G, Abell, C, Blundell, T.L. | | Deposit date: | 2020-05-04 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Acs Infect Dis., 8, 2022
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6YVQ
 | | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in apo form | | Descriptor: | 1,2-ETHANEDIOL, Phosphoribosylaminoimidazole-succinocarboxamide synthase, SULFATE ION | | Authors: | Thomas, S.E, Charoensutthivarakul, S, Coyne, A.G, Abell, C, Blundell, T.L. | | Deposit date: | 2020-04-28 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Acs Infect Dis., 8, 2022
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6YX3
 | | Crystal structure of SAICAR Synthetase (PurC) from Mycobacterium abscessus in complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Phosphoribosylaminoimidazole-succinocarboxamide synthase, ... | | Authors: | Thomas, S.E, Charoensutthivarakul, S, Coyne, A.G, Abell, C, Blundell, T.L. | | Deposit date: | 2020-04-30 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.22 Å) | | Cite: | Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Acs Infect Dis., 8, 2022
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