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PDB: 12 results
2LE4
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BU of 2le4 by Molmil
Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor Sox2
Descriptor: Transcription factor SOX-2
Authors:Sahu, S.C, Markley, J.L, Tonelli, M, Bahrami, A, Eghbalnia, H.R, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2011-06-06
Release date:2011-07-27
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor Sox2
To be Published
6HT5
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BU of 6ht5 by Molmil
Oct4/Sox2:UTF1 structure
Descriptor: DNA (5'-D(*TP*TP*CP*AP*CP*TP*AP*GP*CP*AP*TP*AP*AP*CP*AP*AP*TP*GP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*CP*AP*TP*TP*GP*TP*TP*AP*TP*GP*CP*TP*AP*GP*TP*GP*AP*AP*G)-3'), POU domain, ...
Authors:Vahokoski, J, Meusch, D, Groves, M, Pogenberg, V, Wilmanns, M.
Deposit date:2018-10-03
Release date:2019-10-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.451 Å)
Cite:Oct4/Sox2:UTF1 structure
To Be Published
1GT0
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BU of 1gt0 by Molmil
Crystal structure of a POU/HMG/DNA ternary complex
Descriptor: 5'-D(*AP*TP*CP*CP*CP*AP*TP*TP*AP*GP* CP*AP*TP*CP*CP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', 5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*TP*TP* GP*GP*AP* TP*GP*CP*TP*AP*AP*TP*GP*GP*GP*A)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1, ...
Authors:Remenyi, A, Wilmanns, M.
Deposit date:2002-01-09
Release date:2003-01-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of a POU/Hmg/DNA Ternary Complex Suggests Differential Assembly of Oct4 and Sox2 on Two Enhancers
Genes Dev., 17, 2003
6YOV
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BU of 6yov by Molmil
OCT4-SOX2-bound nucleosome - SHL+6
Descriptor: DNA (142-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2020-04-15
Release date:2020-05-06
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
1O4X
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BU of 1o4x by Molmil
TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Descriptor: 5'-D(*CP*AP*TP*TP*AP*GP*CP*AP*TP*GP*AP*CP*AP*AP*AP*GP*AP*CP*A)-3', 5'-D(*TP*GP*TP*CP*TP*TP*TP*GP*TP*CP*AP*TP*GP*CP*TP*AP*AP*TP*G)-3', Transcription factor SOX-2, ...
Authors:Clore, G.M, Williams, D.C.
Deposit date:2003-07-17
Release date:2004-01-27
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex.
J.Biol.Chem., 279, 2004
8BX1
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BU of 8bx1 by Molmil
Oct4/Sox2 protein:DNA complex
Descriptor: HOXB1_f, HOXB1_r, POU domain, ...
Authors:Chojnowski, G, Wilmanns, M, Round, E.
Deposit date:2022-12-07
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Oct4-Soc2-HoxB1 complex
To Be Published
8BX2
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BU of 8bx2 by Molmil
Oct4/Sox2 protein:DNA complex
Descriptor: POU domain, class 5, transcription factor 1, ...
Authors:Chojnowski, G, Wilmanns, M, Round, E.
Deposit date:2022-12-07
Release date:2023-12-20
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Crystal structure of Oct4-Soc2-UTF1 complex
To Be Published
6T90
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BU of 6t90 by Molmil
OCT4-SOX2-bound nucleosome - SHL-6
Descriptor: DNA (146-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2019-10-25
Release date:2020-05-06
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
6T7B
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BU of 6t7b by Molmil
Structure of human Sox2 transcription factor in complex with a nucleosome
Descriptor: DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ...
Authors:Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P.
Deposit date:2019-10-21
Release date:2020-04-29
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (5.1 Å)
Cite:Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function.
Nature, 580, 2020
6WX7
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BU of 6wx7 by Molmil
SOX2 bound to Importin-alpha 2
Descriptor: Importin subunit alpha-1, Transcription factor SOX-2
Authors:Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N.
Deposit date:2020-05-09
Release date:2020-10-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for nuclear import selectivity of pioneer transcription factor SOX2.
Nat Commun, 12, 2021
6WX8
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BU of 6wx8 by Molmil
SOX2 bound to Importin-alpha 3
Descriptor: Importin subunit alpha-3, SULFATE ION, Transcription factor SOX-2
Authors:Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N.
Deposit date:2020-05-10
Release date:2020-10-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for nuclear import selectivity of pioneer transcription factor SOX2.
Nat Commun, 12, 2021
6WX9
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BU of 6wx9 by Molmil
SOX2 bound to Importin-alpha 5
Descriptor: Importin subunit alpha-5, Transcription factor SOX-2
Authors:Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N.
Deposit date:2020-05-10
Release date:2020-10-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for nuclear import selectivity of pioneer transcription factor SOX2.
Nat Commun, 12, 2021

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