8CCS
 
 | | 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | | Deposit date: | 2023-01-27 | | Release date: | 2023-09-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (1.97 Å) | | Cite: | mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
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8CDR
 | | Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | | Deposit date: | 2023-01-31 | | Release date: | 2023-09-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.04 Å) | | Cite: | mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
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8EVT
 | | Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) refined against a composite map | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Rai, J, Li, H. | | Deposit date: | 2022-10-20 | | Release date: | 2023-09-06 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
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8EVP
 | | Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure I | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Rai, J, Li, H. | | Deposit date: | 2022-10-20 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (2.38 Å) | | Cite: | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
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7ZW0
 | | FAP-80S Complex - Rotated state | | Descriptor: | 18S ribosomal RNA (RDN18-1), 25S ribosomal RNA (RDN25-1), 40S ribosomal protein S0-A, ... | | Authors: | Ikeuchi, K, Buschauer, R, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2022-05-17 | | Release date: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Sensing of individual stalled 80S ribosomes by Fap1 for nonfunctional rRNA turnover.
Mol.Cell, 82, 2022
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7TOP
 | | Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20 | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | Deposit date: | 2022-01-24 | | Release date: | 2022-05-25 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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8AGX
 | | Yeast RQC complex in state with the RING domain of Ltn1 in the IN position | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Tesina, P, Buschauer, R, Beckmann, R. | | Deposit date: | 2022-07-20 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
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8EWC
 | | Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure II | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Rai, J, Li, H. | | Deposit date: | 2022-10-22 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
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8AAF
 | | Yeast RQC complex in state G | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Tesina, P, Buschauer, R, Beckmann, R. | | Deposit date: | 2022-07-01 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
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7ZUX
 | | Collided ribosome in a disome unit from S. cerevisiae | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R. | | Deposit date: | 2022-05-13 | | Release date: | 2023-02-22 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structural basis for clearing of ribosome collisions by the RQT complex.
Nat Commun, 14, 2023
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8EUB
 | | Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure I | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Rai, J, Li, H. | | Deposit date: | 2022-10-18 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
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8AGV
 | | Yeast RQC complex in state H | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Tesina, P, Buschauer, R, Beckmann, R. | | Deposit date: | 2022-07-20 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
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8AGZ
 | | Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Tesina, P, Buschauer, R, Beckmann, R. | | Deposit date: | 2022-07-20 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
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8AGW
 | | Yeast RQC complex in state D | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Tesina, P, Buschauer, R, Beckmann, R. | | Deposit date: | 2022-07-20 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
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8AGT
 | | Yeast RQC complex in state F | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Tesina, P, Buschauer, R, Beckmann, R. | | Deposit date: | 2022-07-20 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
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8EVS
 | | Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Rai, J, Li, H. | | Deposit date: | 2022-10-20 | | Release date: | 2023-09-06 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (2.62 Å) | | Cite: | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
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7MPJ
 | | Stm1 bound vacant 80S structure isolated from wild-type | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Rai, J, Zhao, Y, Li, H. | | Deposit date: | 2021-05-04 | | Release date: | 2022-05-11 | | Last modified: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
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7TOO
 | | Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | Deposit date: | 2022-01-24 | | Release date: | 2022-05-25 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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8AGU
 | | Yeast RQC complex in state E | | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Tesina, P, Buschauer, R, Beckmann, R. | | Deposit date: | 2022-07-20 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
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8EVQ
 | | Hypopseudouridylated Ribosome bound with TSV IRES, eEF2, GDP, and sordarin, Structure I | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Rai, J, Li, H. | | Deposit date: | 2022-10-20 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
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8CDL
 | | 80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | | Deposit date: | 2023-01-31 | | Release date: | 2023-09-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
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4U4R
 | | Crystal structure of Lactimidomycin bound to the yeast 80S ribosome | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione, ... | | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | | Deposit date: | 2014-07-24 | | Release date: | 2014-10-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.801 Å) | | Cite: | Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513, 2014
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8EVR
 | | Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II | | Descriptor: | (1S,3S,3aR,4S,4aR,7R,7aR,8aS)-8a-{[(6-deoxy-4-O-methyl-alpha-D-altropyranosyl)oxy]methyl}-4-formyl-7-methyl-3-(propan-2-yl)decahydro-1,4-methano-s-indacene-3a(1H)-carboxylate, 18S rRNA, 25S rRNA, ... | | Authors: | Zhao, Y, Rai, J, Li, H. | | Deposit date: | 2022-10-20 | | Release date: | 2023-09-06 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (2.87 Å) | | Cite: | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
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8EWB
 | | Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure III | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Zhao, Y, Rai, J, Li, H. | | Deposit date: | 2022-10-22 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (2.87 Å) | | Cite: | Regulation of translation by ribosomal RNA pseudouridylation.
Sci Adv, 9, 2023
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7OLC
 | | Thermophilic eukaryotic 80S ribosome at idle POST state | | Descriptor: | 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... | | Authors: | Kisonaite, M, Wild, K, Sinning, I. | | Deposit date: | 2021-05-19 | | Release date: | 2022-01-26 | | Last modified: | 2022-04-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.
Nat Commun, 13, 2022
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