4U3U

Crystal structure of Cycloheximide bound to the yeast 80S ribosome

This is a large structure.

Summary for 4U3U

Integrates4uk9 4uka 4ukb 4ukc 4uke
Descriptor18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... (89 entities in total)
Functional Keywordstranslation, ribosome, 40s, 60s, 80s, eukaryote, rna-protein complex, inhibitor, antibiotic
Biological sourceSaccharomyces cerevisiae S288c
Total number of polymer chains162
Total molecular weight6631498.96
Authors
Garreau de Loubresse, N.,Prokhorova, I.,Yusupova, G.,Yusupov, M. (deposition date: 2014-07-22, release date: 2014-10-22, Last modification date: 2018-07-18)
Primary citation
Garreau de Loubresse, N.,Prokhorova, I.,Holtkamp, W.,Rodnina, M.V.,Yusupova, G.,Yusupov, M.
Structural basis for the inhibition of the eukaryotic ribosome.
Nature, 513:517-522, 2014
PubMed: 25209664 (PDB entries with the same primary citation)
DOI: 10.1038/nature13737
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone125.1%18.2%0.46MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4u3u
no rotation
Molmil generated image of 4u3u
rotated about x axis by 90°
Molmil generated image of 4u3u
rotated about y axis by 90°