2CE2
| CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GDP | Descriptor: | GTPASE HRAS, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Klink, B.U, Goody, R.S, Scheidig, A.J. | Deposit date: | 2006-02-02 | Release date: | 2006-08-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | A Newly Designed Microspectrofluorometer for Kinetic Studies on Protein Crystals in Combination with X-Ray Diffraction Biophys.J., 91, 2006
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2EVW
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8TBG
| Tricomplex of RMC-7977, HRAS WT, and CypA | Descriptor: | (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide, GLYCEROL, GTPase HRas, ... | Authors: | Chen, A, Tomlinson, A.C.A, Knox, J.E, Yano, J.K. | Deposit date: | 2023-06-28 | Release date: | 2024-02-07 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629, 2024
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2CLD
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2CL6
| CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH S-caged GTP | Descriptor: | GTPASE HRAS, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION, ... | Authors: | Klink, B.U, Goody, R.S, Scheidig, A.J. | Deposit date: | 2006-04-26 | Release date: | 2006-05-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | A Newly Designed Microspectrofluorometer for Kinetic Studies on Protein Crystals in Combination with X-Ray Diffraction. Biophys.J., 91, 2006
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2CL7
| CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GTP | Descriptor: | GTPASE HRAS, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Klink, B.U, Goody, R.S, Scheidig, A.J. | Deposit date: | 2006-04-26 | Release date: | 2006-05-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | A Newly Designed Microspectrofluorometer for Kinetic Studies on Protein Crystals in Combination with X-Ray Diffraction. Biophys.J., 91, 2006
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5WDQ
| H-Ras mutant L120A bound to GMP-PNP at 100K | Descriptor: | ACETATE ION, CALCIUM ION, GTPase HRas, ... | Authors: | Bandaru, P, Gee, C.L, Kuriyan, J. | Deposit date: | 2017-07-05 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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1CTQ
| STRUCTURE OF P21RAS IN COMPLEX WITH GPPNHP AT 100 K | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN (TRANSFORMING PROTEIN P21/H-RAS-1) | Authors: | Scheidig, A, Burmester, C, Goody, R.S. | Deposit date: | 1999-08-20 | Release date: | 1999-11-15 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. Structure Fold.Des., 7, 1999
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3K8Y
| Allosteric modulation of H-Ras GTPase | Descriptor: | ACETATE ION, CALCIUM ION, GTPase HRas, ... | Authors: | Holzapfel, G, Buhrman, G, Mattos, C. | Deposit date: | 2009-10-15 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc.Natl.Acad.Sci.USA, 107, 2010
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2CLC
| CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GTP (2) | Descriptor: | GTPASE HRAS, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Klink, B.U, Goody, R.S, Scheidig, A.J. | Deposit date: | 2006-04-27 | Release date: | 2006-05-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | A Newly Designed Microspectrofluorometer for Kinetic Studies on Protein Crystals in Combination with X-Ray Diffraction Biophys.J., 91, 2006
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3OIW
| H-RasG12V with allosteric switch in the "on" state | Descriptor: | ACETATE ION, CALCIUM ION, GTPase HRas, ... | Authors: | Kumar, S, Buhrman, G, Mattos, C. | Deposit date: | 2010-08-20 | Release date: | 2010-12-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286, 2011
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3TGP
| Room temperature H-ras | Descriptor: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Fraser, J.S, Alber, T. | Deposit date: | 2011-08-17 | Release date: | 2011-10-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.3075 Å) | Cite: | Accessing protein conformational ensembles using room-temperature X-ray crystallography. Proc.Natl.Acad.Sci.USA, 108, 2011
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4DLR
| H-Ras PEG 400/Ca(OAc)2, ordered off | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, CALCIUM ION, GTPase HRas, ... | Authors: | Holzapfel, G, Mattos, C. | Deposit date: | 2012-02-06 | Release date: | 2012-08-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.319 Å) | Cite: | Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
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3OIU
| H-RasQ61L with allosteric switch in the "on" state | Descriptor: | ACETATE ION, CALCIUM ION, GTPase HRas, ... | Authors: | Buhrman, G, Mattos, C. | Deposit date: | 2010-08-20 | Release date: | 2010-12-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286, 2011
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8BWG
| HRas (1-166) Y64 phosphorylation | Descriptor: | GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Baumann, P, Jin, Y. | Deposit date: | 2022-12-06 | Release date: | 2023-09-27 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF 3 - complexes. Commun Chem, 7, 2024
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5P21
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8CNJ
| HRas(1-166) in complex with GDP and BeF3- | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, BERYLLIUM TRIFLUORIDE ION, GTPase HRas, ... | Authors: | Baumann, P, Jin, Y. | Deposit date: | 2023-02-23 | Release date: | 2023-09-27 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF 3 - complexes. Commun Chem, 7, 2024
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2RGB
| Crystal structure of H-RasQ61K-GppNHp | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Buhrman, G, Wink, G, Mattos, C. | Deposit date: | 2007-10-03 | Release date: | 2007-12-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
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5WDP
| H-Ras mutant L120A bound to GMP-PNP at 277K | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | Deposit date: | 2017-07-05 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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3I3S
| Crystal Structure of H-Ras with Thr50 replaced by Isoleucine | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Gremer, L, Dvorsky, R, Merbitz-Zahradnik, T, Wittinghofer, A, Ahmadian, M.R. | Deposit date: | 2009-06-30 | Release date: | 2009-12-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat.Genet., 42, 2010
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2RGE
| Crystal structure of H-Ras-GppNHp | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Buhrman, G, Wink, G, Mattos, C. | Deposit date: | 2007-10-03 | Release date: | 2007-12-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
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3RS0
| H-Ras soaked in neat cyclopentanol: one of 10 in MSCS set | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Mattos, C, Buhrman, G, Kearney, B. | Deposit date: | 2011-05-02 | Release date: | 2011-09-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Analysis of Binding Site Hot Spots on the Surface of Ras GTPase. J.Mol.Biol., 413, 2011
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5E95
| Crystal Structure of Mb(NS1)/H-Ras Complex | Descriptor: | GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Eguchi, R.R, Sha, F, Gupta, A, Koide, A, Koide, S. | Deposit date: | 2015-10-14 | Release date: | 2016-11-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.402 Å) | Cite: | Inhibition of RAS function through targeting an allosteric regulatory site. Nat. Chem. Biol., 13, 2017
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3L8Z
| H-Ras wildtype new crystal form | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Rosnizeck, I.C, Graf, T, Spoerner, M, Traenkle, J, Filchtinski, D, Herrmann, C, Gremer, L, Vetter, I.R, Wittinghofer, A, Koenig, B, Kalbitzer, H.R. | Deposit date: | 2010-01-04 | Release date: | 2011-01-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes Angew.Chem.Int.Ed.Engl., 49, 2010
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2RGG
| Crystal structure of H-RasQ61I-GppNHp, trigonal crystal form | Descriptor: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Buhrman, G, Wink, G, Mattos, C. | Deposit date: | 2007-10-03 | Release date: | 2007-12-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf. Structure, 15, 2007
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