PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Crystal structure of human Sphingosine-1-phosphate lyase 1
Descriptor:	ACETATE ION, GLYCEROL, Sphingosine-1-phosphate lyase 1
Authors:	Giardina, G, Catalano, F, Pampalone, G, Cellini, B.
Deposit date:	2022-09-02
Release date:	2023-09-13
Last modified:	2024-01-03
Method:	X-RAY DIFFRACTION (1.84 Å)
Cite:	Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study. Sci Rep, 13, 2023

Crystal structure of human sphingosine-1-phosphate lyase in complex with inhibitor 6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile
Descriptor:	6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile, GLYCEROL, PHOSPHATE ION, ...
Authors:	Srinivas, H.
Deposit date:	2014-04-23
Release date:	2014-05-21
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis. J.Med.Chem., 57, 2014