4OKI
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5NJI
| Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA | Descriptor: | Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate | Authors: | Gavalda, S, Faille, A, Mourey, L, Pedelacq, J.D. | Deposit date: | 2017-03-28 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases. J. Mol. Biol., 429, 2017
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7AHB
| Acyltransferase domain of the polyketide synthase PpsC of Mycobacterium tuberculosis | Descriptor: | GLYCEROL, Phthiocerol synthesis polyketide synthase type I PpsC, SODIUM ION, ... | Authors: | Faille, A, Mourey, L, Pedelacq, J.D. | Deposit date: | 2020-09-24 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. Acs Chem.Biol., 15, 2020
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6RCX
| Mycobacterial 4'-phosphopantetheinyl transferase PptAb in complex with the ACP domain of PpsC. | Descriptor: | CACODYLATE ION, COENZYME A, MANGANESE (II) ION, ... | Authors: | Nguyen, M.C, Mourey, L, Pedelacq, J.D. | Deposit date: | 2019-04-12 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational flexibility of coenzyme A and its impact on the post-translational modification of acyl carrier proteins by 4'-phosphopantetheinyl transferases. Febs J., 287, 2020
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8QZI
| Crystal structure of PptT-ACP from Mycobacterium tuberculosis | Descriptor: | 4'-phosphopantetheinyl transferase PptT, COENZYME A, ISOPROPYL ALCOHOL, ... | Authors: | Gavalda, S, Mourey, L, Pedelacq, J.D. | Deposit date: | 2023-10-27 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Catalytic Cycle of Type II 4'-Phosphopantetheinyl Transferases Acs Catalysis, 14, 2024
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7BDW
| Crystal structure of mycobacterial PptAb in complex with ACP and compound 8918 | Descriptor: | COENZYME A, MANGANESE (II) ION, N-(2,6-diethylphenyl)-N'-(N-ethylcarbamimidoyl)urea, ... | Authors: | Carivenc, C, Nguyen, M.C, Mourey, L, Pedelacq, J.D. | Deposit date: | 2020-12-22 | Release date: | 2021-11-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds. Sci Rep, 11, 2021
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1PQW
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4OOC
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5L84
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5I0K
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