9MW9
 
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9MUE
 | | Cryo-EM structure of CRISPR-associated cA4 bound Cat1 Pentagonal filament assembly in the presence of NAD (ADPR modelled) | | Descriptor: | Cat1 (CRISPR associated TIR 1) pentagonal filament assembly, RNA (5'-R(P*AP*AP*AP*A)-3'), [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | Authors: | Majumder, P, Patel, D.J. | | Deposit date: | 2025-01-13 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Cat1 forms filament networks to degrade NAD + during the type III CRISPR-Cas antiviral response.
Science, 388, 2025
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9MUD
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9MUO
 | | Cryo-EM structure of CRISPR-associated cA4 bound Cat1 Pentagonal filament assembly in the presence of NAD analog BAD | | Descriptor: | Cat1 (CRISPR-associated TIR 1), RNA (5'-R(P*AP*AP*AP*A)-3'), [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) | | Authors: | Majumder, P, Patel, D.J. | | Deposit date: | 2025-01-14 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cat1 forms filament networks to degrade NAD + during the type III CRISPR-Cas antiviral response.
Science, 388, 2025
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