9B4U
 
 | | Crystal structure of p110alpha-RBD covalently bound to a breaker compound BBO-10203 via Cys242 | | Descriptor: | 1-[(4R,8R)-2-[(4M,7P)-7-[2,4-difluoro-6-(2-methoxyethoxy)phenyl]-4-(1-methyl-1H-indazol-5-yl)thieno[3,2-c]pyridin-6-yl]-4-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl]propan-1-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | Authors: | Czyzyk, D.J, Simanshu, D.K. | | Deposit date: | 2024-03-21 | | Release date: | 2025-06-25 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3K alpha interaction.
Science, 389, 2025
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