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PDB: 8 results
1HWI
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BU of 1hwi by Molmil
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH FLUVASTATIN
Descriptor: (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid, ADENOSINE-5'-DIPHOSPHATE, HMG-COA REDUCTASE
Authors:Istvan, E.S, Deisenhofer, J.
Deposit date:2001-01-09
Release date:2001-05-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural mechanism for statin inhibition of HMG-CoA reductase.
Science, 292, 2001
1HW9
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BU of 1hw9 by Molmil
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH SIMVASTATIN
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HMG-COA REDUCTASE, Simvastatin acid
Authors:Istvan, E.S, Deisenhofer, J.
Deposit date:2001-01-09
Release date:2001-05-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural mechanism for statin inhibition of HMG-CoA reductase.
Science, 292, 2001
1HWK
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BU of 1hwk by Molmil
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ATORVASTATIN
Descriptor: 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, HMG-COA REDUCTASE
Authors:Istvan, E.S, Deisenhofer, J.
Deposit date:2001-01-09
Release date:2001-05-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural mechanism for statin inhibition of HMG-CoA reductase.
Science, 292, 2001
1HW8
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BU of 1hw8 by Molmil
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH COMPACTIN (ALSO KNOWN AS MEVASTATIN)
Descriptor: (3R,5R)-3,5-dihydroxy-7-[(1S,2S,8S,8aR)-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]h eptanoic acid, ADENOSINE-5'-DIPHOSPHATE, HMG-COA REDUCTASE
Authors:Istvan, E.S, Deisenhofer, J.
Deposit date:2001-01-09
Release date:2001-05-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural mechanism for statin inhibition of HMG-CoA reductase.
Science, 292, 2001
1HWL
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BU of 1hwl by Molmil
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ROSUVASTATIN (FORMALLY KNOWN AS ZD4522)
Descriptor: 7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, HMG-COA REDUCTASE
Authors:Istvan, E.S, Deisenhofer, J.
Deposit date:2001-01-09
Release date:2001-05-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural mechanism for statin inhibition of HMG-CoA reductase.
Science, 292, 2001
1HWJ
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BU of 1hwj by Molmil
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH CERIVASTATIN
Descriptor: 7-[4-(4-FLUORO-PHENYL)-5-HYDROXYMETHYL-2,6-DIISOPROPYL-PYRIDIN-3-YL]-3,5-DIHYDROXY-HEPTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, HMG-COA REDUCTASE
Authors:Istvan, E.S, Deisenhofer, J.
Deposit date:2001-01-09
Release date:2001-05-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural mechanism for statin inhibition of HMG-CoA reductase.
Science, 292, 2001
8PKN
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BU of 8pkn by Molmil
CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin
Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID
Authors:Manikandan, K, Van Rooyen, J.
Deposit date:2023-06-27
Release date:2025-01-15
Last modified:2025-03-12
Method:ELECTRON MICROSCOPY (2.26 Å)
Cite:Cryo-EM structures of apo and atorvastatin-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Acta Crystallogr.,Sect.F, 81, 2025
8S6B
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BU of 8s6b by Molmil
CryoEM structure of Apo form of catalytic domain of human HMG-CoA reductase
Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Authors:Manikandan, K, Van Rooyen, J.
Deposit date:2024-02-27
Release date:2025-02-26
Last modified:2025-03-12
Method:ELECTRON MICROSCOPY (2.06 Å)
Cite:Cryo-EM structures of apo and atorvastatin-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Acta Crystallogr.,Sect.F, 81, 2025

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PDB entries from 2025-07-09

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