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Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-isopropyl-5-methyl-4-(pyridin-4-yloxy)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
Descriptor:	ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:	Alberti, M, Miggiano, R.
Deposit date:	2023-12-01
Release date:	2024-06-19
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent. Acta Crystallogr D Struct Biol, 80, 2024