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PDB: 3 results

Fragment-Based Discovery of a Small Molecule Reversible Inhibitor of Bruton's Tyrosine Kinase
Descriptor:	1,2-ETHANEDIOL, 4-amino-8-(5-methyl-1H-indazol-6-yl)cinnoline-3-carboxamide, IMIDAZOLE, ...
Authors:	Dougan, D.R.
Deposit date:	2015-03-31
Release date:	2015-07-01
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase. J.Med.Chem., 58, 2015

Crystal Structure of Bruton's Tyrosine Kinase in complex with a substituted Cinnoline
Descriptor:	4-amino-8-(4-methylpyridin-3-yl)cinnoline-3-carboxamide, DIMETHYL SULFOXIDE, IMIDAZOLE, ...
Authors:	Dougan, D.R.
Deposit date:	2015-05-01
Release date:	2015-07-01
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase. J.Med.Chem., 58, 2015

Crystal Structure of Bruton's Tyrosine Kinase bound to a Cinnoline Fragment
Descriptor:	4-aminocinnoline-3-carboxamide, DIMETHYL SULFOXIDE, IMIDAZOLE, ...
Authors:	Dougan, D.R.
Deposit date:	2015-05-01
Release date:	2015-07-01
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase. J.Med.Chem., 58, 2015