8RBC
 
 | | p53-Y220C Core Domain Covalently Bound to 3-amino-5-chloropyrazine-2,6-dicarbonitrile Soaked at 5 mM | | Descriptor: | 3-azanylpyrazine-2,6-dicarbonitrile, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cellular tumor antigen p53, ... | | Authors: | Stahlecker, J, Klett, T, Stehle, T, Boeckler, F.M. | | Deposit date: | 2023-12-04 | | Release date: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution
Acs Pharmacol Transl Sci, 2024
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8RBB
 | | p53-Y220C Core Domain Covalently Bound to 2,5,6-trifluoropyridine-3-carbonitrile Soaked at 40 mM | | Descriptor: | 1,2-ETHANEDIOL, 2,5-bis(fluoranyl)pyridine-3-carbonitrile, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Stahlecker, J, Klett, T, Stehle, T, Boeckler, F.M. | | Deposit date: | 2023-12-04 | | Release date: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution
Acs Pharmacol Transl Sci, 2024
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8RBA
 | | p53-Y220C Core Domain Covalently Bound to 2,5,6-trifluoropyridine-3-carbonitrile Soaked at 5 mM | | Descriptor: | 1,2-ETHANEDIOL, 2,5-bis(fluoranyl)pyridine-3-carbonitrile, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Stahlecker, J, Klett, T, Stehle, T, Boeckler, F.M. | | Deposit date: | 2023-12-04 | | Release date: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution
Acs Pharmacol Transl Sci, 2024
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