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PDB: 1 results

4PGZ
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BU of 4pgz by Molmil
Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, Mast/stem cell growth factor receptor Kit
Authors:Reshetnyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
Deposit date:2014-05-03
Release date:2015-03-18
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57, 2015

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