PDB Search results for query - Protein Data Bank Japan

PDB: 3 results

Selective pharmacological inhibition of the CREB binding protein bromodomain regulates inflammatory cytokines in macrophages and RGS4 in neurons
Descriptor:	5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole, Bromodomain-containing protein 4
Authors:	Chekler, E.L, Jones, L.H.
Deposit date:	2015-07-08
Release date:	2016-04-20
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.15 Å)
Cite:	Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem.Biol., 22, 2015

Selective pharmacological inhibition of the CREB binding protein bromodomain regulates inflammatory cytokines in macrophages and RGS4 in neurons
Descriptor:	5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole, CREB-binding protein
Authors:	Chekler, E.L, Jones, L.H.
Deposit date:	2015-07-09
Release date:	2016-04-20
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.96 Å)
Cite:	Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem.Biol., 22, 2015

A multiconformer ligand model of inhibitor 53W bound to CREB binding protein bromodomain
Descriptor:	5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole, Bromodomain-containing protein 4
Authors:	Hudson, B.M, van Zundert, G, Keedy, D.A, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H.
Deposit date:	2018-06-05
Release date:	2018-12-19
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (1.15 Å)
Cite:	qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps. J. Med. Chem., 61, 2018