PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor.
Descriptor:	3-{6-[(4R)-6-azaspiro[2.5]oct-4-yloxy]pyrazin-2-yl}-5-(2,6-difluorophenyl)-1H-indazole, GLYCEROL, Serine/threonine-protein kinase pim-1
Authors:	Mohr, C.
Deposit date:	2014-10-25
Release date:	2015-02-04
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015

co-crystal structure of Pim1 with compound 3
Descriptor:	(3S)-1-{6-[5-(2,6-difluorophenyl)-2H-indazol-3-yl]pyrazin-2-yl}piperidin-3-amine, Serine/threonine-protein kinase pim-1
Authors:	Huang, X.
Deposit date:	2014-10-31
Release date:	2015-02-04
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (3.05 Å)
Cite:	The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015