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3HSC	THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 7OKD PROTEIN, MAGNESIUM ION, ... Authors: Flaherty, K.M, Deluca-Flaherty, C.R, Mckay, D.B. Deposit date: 1995-03-24 Release date: 1995-07-10 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature, 346, 1990
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... Authors: Wang, W, Hendrickson, W.A. Deposit date: 2021-07-04 Release date: 2023-07-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Visualization of Hsp70-catalyzed ATP Hydrolysis To Be Published
2KHO	NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate Descriptor: Heat shock protein 70 Authors: Zuiderweg, E.R.P, Bertelsen, E.B. Deposit date: 2009-04-10 Release date: 2009-05-12 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc.Natl.Acad.Sci.USA, 106, 2009
6NHK	Mortalin nucleotide binding domain in the ADP-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Page, R.C, Moseng, M.A, Nix, J.C. Deposit date: 2018-12-23 Release date: 2019-04-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.777 Å) Cite: Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
6ZHI	Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide Descriptor: ASN-ARG-LEU-LEU-LEU-THR-GLY, Heat shock protein 70 Authors: Schmidt, J, Vakonakis, I. Deposit date: 2020-06-23 Release date: 2020-09-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structure of the PfHsp70-x SBD Acta Crystallographica Section F
5XI9	Solution structure for human HSP70 substrate binding domain Descriptor: Heat shock 70 kDa protein 1A Authors: Hoshikawa, M, Tochio, N, Tate, S. Deposit date: 2017-04-26 Release date: 2018-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
5XIR	Solution structure for human HSP70 substrate binding domain L542Y mutant Descriptor: Heat shock 70 kDa protein 1A Authors: Hoshikawa, M, Tochio, N, Tate, S. Deposit date: 2017-04-27 Release date: 2018-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
1U00	HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC Descriptor: Chaperone protein hscA, IscU recognition peptide Authors: Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E. Deposit date: 2004-07-12 Release date: 2004-10-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC. J.Mol.Biol., 342, 2004
6P2U	Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate Descriptor: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Moseng, M.A, Page, R.C. Deposit date: 2019-05-22 Release date: 2019-06-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
1S3X	The crystal structure of the human Hsp70 ATPase domain Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ... Authors: Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A. Deposit date: 2004-01-14 Release date: 2004-01-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain Structure, 5, 1997
6PMT	Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ... Authors: Moseng, M.A, Nix, J.C, Page, R.C. Deposit date: 2019-07-02 Release date: 2020-07-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate to be published
4JWC	Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(1-16) Descriptor: Cathelicidin-3, Chaperone protein DnaK, SULFATE ION Authors: Zahn, M, Straeter, N. Deposit date: 2013-03-27 Release date: 2013-11-13 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Identification of DnaK Binding Sites within Bovine and Sheep Bactenecin Bac7. Protein Pept.Lett., 21, 2014
4KBO	Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form Descriptor: SODIUM ION, Stress-70 protein, mitochondrial Authors: Amick, J, Page, R.C, Nix, J.C, Misra, S. Deposit date: 2013-04-23 Release date: 2014-04-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone. Protein Sci., 23, 2014
1YUW	crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant Descriptor: Heat shock cognate 71 kDa protein Authors: Jiang, J, Lafer, E.M, Prasad, K, Sousa, R. Deposit date: 2005-02-14 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of interdomain communication in the Hsc70 chaperone Mol.Cell, 20, 2005
5TKY	Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein Authors: Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. Deposit date: 2016-10-10 Release date: 2016-11-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun, 7, 2016
5UMB	Crystal structure of ATPase domain of Malaria GRP78 with ADP bound Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ... Authors: Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H. Deposit date: 2017-01-26 Release date: 2022-07-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Repurposing drugs to target the malaria parasite unfolding protein response. Sci Rep, 8, 2018
5MB9	Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I. Deposit date: 2016-11-07 Release date: 2016-12-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex. Nat. Struct. Mol. Biol., 24, 2017
5MKS	HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, Heat shock 70 kDa protein 1A Authors: Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. Deposit date: 2016-12-05 Release date: 2017-03-01 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.99 Å) Cite: An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... Authors: Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. Deposit date: 2019-09-05 Release date: 2020-03-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
6RZQ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state Descriptor: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ... Authors: Vakonakis, I, Day, J. Deposit date: 2019-06-13 Release date: 2019-10-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.81 Å) Cite: ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
5MKR	HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, CITRATE ANION, Heat shock 70 kDa protein 1A Authors: Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. Deposit date: 2016-12-05 Release date: 2017-03-01 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.87 Å) Cite: An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION Authors: Vakonakis, I, Day, J. Deposit date: 2019-06-13 Release date: 2019-10-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.87 Å) Cite: ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
7P31	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818 Descriptor: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ... Authors: Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. Deposit date: 2021-07-06 Release date: 2021-07-14 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with small molecule ligands To Be Published
4EZN	Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin Descriptor: Chaperone protein DnaK, Pyrrhocoricin Authors: Zahn, M, Straeter, N. Deposit date: 2012-05-03 Release date: 2013-04-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4EZX	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the designer peptide NRLMLTG Descriptor: Chaperone protein DnaK, SULFATE ION, synthetic peptide NRLMLTG Authors: Zahn, M, Straeter, N. Deposit date: 2012-05-03 Release date: 2013-04-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013

 

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