7TKK
 
 | |
7TKQ
 | |
7TKG
 | |
8WBY
 | | Cryo-EM structure of ACE2-B0AT1 complex with JX98 | | Descriptor: | 2-(4-chloranyl-3,5-dimethyl-phenoxy)-~{N}-propan-2-yl-ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Yan, R, Hu, Z, Dai, L. | | Deposit date: | 2023-09-10 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Molecular basis of inhibition of the amino acid transporter B 0 AT1 (SLC6A19).
Nat Commun, 15, 2024
|
|
7TKJ
 | |
7TKS
 | |
8WM9
 | | Fzd4/DEP complex | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Frizzled-4, Segment polarity protein dishevelled homolog DVL-2 | | Authors: | He, Y, Qian, Y. | | Deposit date: | 2023-10-03 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation.
Nat Commun, 15, 2024
|
|
7TZC
 | | A drug and ATP binding site in type 1 ryanodine receptor | | Descriptor: | (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Melville, Z, Dridi, H, Yuan, Q, Reiken, S, Anetta, W, Liu, Y, Clarke, O.B, Marks, A.R. | | Deposit date: | 2022-02-15 | | Release date: | 2022-05-18 | | Last modified: | 2022-07-20 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | A drug and ATP binding site in type 1 ryanodine receptor.
Structure, 30, 2022
|
|
8VU5
 | |
7TKL
 | |
7TKO
 | |
7TKN
 | |
7TKF
 | |
8WG3
 | | mouse TMEM63b in LMNG-CHS micelle | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL HEMISUCCINATE, CSC1-like protein 2,Green fluorescent protein | | Authors: | Miyata, Y, Takahashi, K, Lee, Y, Sultan, C.S, Kuribayashi, R, Takahashi, M, Hata, K, Bamba, T, Izumi, Y, Liu, K, Uemura, T, Nomura, N, Iwata, S, Nagata, S, Nishizawa, T, Segawa, K. | | Deposit date: | 2023-09-20 | | Release date: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Mechanosensitive channel TMEM63B functions as a plasma membrane lipid scramblase
To Be Published
|
|
7TOS
 | | E. coli 70S ribosomes bound with the ALS/FTD-associated dipeptide repeat protein PR20 | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | Deposit date: | 2022-01-24 | | Release date: | 2022-05-25 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
|
|
7U1N
 | | Crystal structure of the Anopheles darlingi AD-118 long form D7 salivary protein | | Descriptor: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, 2-ETHOXYETHANOL, ... | | Authors: | Alvarenga, P.H, Gittis, A.G, Garboczi, D.N, Andersen, J.F. | | Deposit date: | 2022-02-21 | | Release date: | 2022-05-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes.
Insect Biochem.Mol.Biol., 146, 2022
|
|
8WRE
 | | Transporter bound with dopamine | | Descriptor: | FabH, FabL, L-DOPAMINE, ... | | Authors: | Im, D, Iwata, S. | | Deposit date: | 2023-10-13 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Neurotransmitter recognition by human vesicular monoamine transporter 2.
Nat Commun, 15, 2024
|
|
8WEW
 | |
7TX8
 | | Long form D7 protein from Anopheles darlingi with U46619 and serotonin bound | | Descriptor: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Long form D7 salivary protein, SEROTONIN | | Authors: | Andersen, J.F, Alvarenga, P.H. | | Deposit date: | 2022-02-08 | | Release date: | 2022-06-01 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes.
Insect Biochem.Mol.Biol., 146, 2022
|
|
7U1D
 | |
8WG4
 | | mouse TMEM63b in DDM-CHS micelle with YN9303-24 Fab | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL HEMISUCCINATE, CSC1-like protein 2,Green fluorescent protein | | Authors: | Miyata, Y, Takahashi, K, Lee, Y, Sultan, C.S, Kuribayashi, R, Takahashi, M, Hata, K, Bamba, T, Izumi, Y, Liu, K, Uemura, T, Nomura, N, Iwata, S, Nagata, S, Nishizawa, T, Segawa, K. | | Deposit date: | 2023-09-20 | | Release date: | 2024-09-25 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Mechanosensitive channel TMEM63B functions as a plasma membrane lipid scramblase
To Be Published
|
|
8WRD
 | | Transporter apo state | | Descriptor: | FabH, FabL, Synaptic vesicular amine transporter | | Authors: | Im, D, Iwata, S. | | Deposit date: | 2023-10-13 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Neurotransmitter recognition by human vesicular monoamine transporter 2.
Nat Commun, 15, 2024
|
|
7TM3
 | | Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | | Deposit date: | 2022-01-19 | | Release date: | 2022-10-19 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins.
Nature, 611, 2022
|
|
8VWX
 | | Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to Maltose-Binding Protein | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera | | Authors: | Baird, J, Holliday, M. | | Deposit date: | 2024-02-02 | | Release date: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics
To Be Published
|
|
8VWZ
 | | Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746 | | Descriptor: | DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide | | Authors: | Baird, J, Holliday, M. | | Deposit date: | 2024-02-02 | | Release date: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics
To Be Published
|
|
