6PAC
 
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1LRN
 | | Aquifex aeolicus KDO8P synthase H185G mutant in complex with Cadmium | | Descriptor: | CADMIUM ION, KDO-8-phosphate synthetase, PHOSPHATE ION | | Authors: | Wang, J, Duewel, H.S, Stuckey, J.A, Woodard, R.W, Gatti, D.L. | | Deposit date: | 2002-05-15 | | Release date: | 2002-11-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Function of His185 in Aquifex aeolicus 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase
J.Mol.Biol., 324, 2002
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3JTA
 | | Structure of neuronal nitric oxide synthase heme domain in the ferrous state complexed with N~5~-[4-(methylsulfanyl)butanimidoyl]-L-ornithine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, Nitric oxide synthase, ... | | Authors: | Li, H, Poulos, T.L. | | Deposit date: | 2009-09-11 | | Release date: | 2010-01-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
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2WOH
 | | Strontium soaked E. coli copper amine oxidase | | Descriptor: | CALCIUM ION, COPPER (II) ION, PRIMARY AMINE OXIDASE, ... | | Authors: | Smith, M.A, Pirrat, P, Pearson, A.R, Knowles, P.F, Phillips, S.E.V, McPherson, M.J. | | Deposit date: | 2009-07-23 | | Release date: | 2010-05-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Exploring the Roles of the Metal Ions in Escherichia Coli Copper Amine Oxidase.
Biochemistry, 49, 2010
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2E82
 | | Crystal structure of human D-amino acid oxidase complexed with imino-DOPA | | Descriptor: | (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Kawazoe, T, Tsuge, H, Imagawa, T, Kuramitsu, S, Fukui, K. | | Deposit date: | 2007-01-16 | | Release date: | 2007-03-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis of d-DOPA oxidation by d-amino acid oxidase: Alternative pathway for dopamine biosynthesis.
Biochem.Biophys.Res.Commun., 355, 2007
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8TRB
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist JNJ47965567 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.36 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TRA
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-L-prolinamide, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TRK
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist methyl blue | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4',4''-[methanetriyltris(4,1-phenyleneazanediyl)]tri(benzene-1-sulfonic acid), GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TR7
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A839977 | | Descriptor: | (1P)-1-(2,3-dichlorophenyl)-N-({2-[(pyridin-2-yl)oxy]phenyl}methyl)-1H-tetrazol-5-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TR8
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[(3s,5s,7s)-adamantan-1-yl]methyl}-2-chloro-5-{3-[(3-hydroxypropyl)amino]propyl}benzamide, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.21 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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8TR6
 | | Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A438079 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{[(5R)-5-(2,3-dichlorophenyl)tetrazolidin-1-yl]methyl}pyridine, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. | | Deposit date: | 2023-08-09 | | Release date: | 2024-10-16 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.18 Å) | | Cite: | P2X 7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv, 10, 2024
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1DDZ
 | | X-RAY STRUCTURE OF A BETA-CARBONIC ANHYDRASE FROM THE RED ALGA, PORPHYRIDIUM PURPUREUM R-1 | | Descriptor: | CARBONIC ANHYDRASE, ZINC ION | | Authors: | Mitsuhashi, S, Mizushima, T, Yamashita, E, Miyachi, S, Tsukihara, T. | | Deposit date: | 1999-11-12 | | Release date: | 2000-03-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | X-ray structure of beta-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO(2) hydration.
J.Biol.Chem., 275, 2000
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4E2Y
 | | X-ray Structure of the E224Q mutant of TcaB9, a C-3'-Methyltransferase, in Complex with S-Adenosyl-L-Homocysteine and Sugar Product | | Descriptor: | (2R,4S,6R)-4-amino-4,6-dimethyl-5-oxotetrahydro-2H-pyran-2-yl [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name), S-ADENOSYL-L-HOMOCYSTEINE, TcaB9, ... | | Authors: | Bruender, N.A, Holden, H.M. | | Deposit date: | 2012-03-09 | | Release date: | 2012-04-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Probing the catalytic mechanism of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose.
Protein Sci., 21, 2012
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5M96
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7MMZ
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1DLQ
 | | STRUCTURE OF CATECHOL 1,2-DIOXYGENASE FROM ACINETOBACTER SP. ADP1 INHIBITED BY BOUND MERCURY | | Descriptor: | CATECHOL 1,2-DIOXYGENASE, FE (III) ION, MERCURY (II) ION, ... | | Authors: | Vetting, M.W, Ohlendorf, D.H. | | Deposit date: | 1999-12-11 | | Release date: | 2000-05-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The 1.8 A crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker.
Structure Fold.Des., 8, 2000
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1DCP
 | | DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR, COMPLEXED WITH BIOPTERIN | | Descriptor: | 7,8-DIHYDROBIOPTERIN, DCOH | | Authors: | Cronk, J.D, Endrizzi, J.A, Alber, T. | | Deposit date: | 1996-05-16 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue.
Protein Sci., 5, 1996
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3MAV
 | | Crystal structure of Plasmodium vivax putative farnesyl pyrophosphate synthase (Pv092040) | | Descriptor: | Farnesyl pyrophosphate synthase, SULFATE ION | | Authors: | Dong, A, Dunford, J, Lew, J, Wernimont, A.K, Ren, H, Zhao, Y, Koeieradzki, I, Opperman, U, Sundstrom, M, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) | | Deposit date: | 2010-03-24 | | Release date: | 2010-04-14 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
J.Biol.Chem., 286, 2011
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3JT9
 | | Structure of neuronal nitric oxide synthase heme domain in the ferrous state complexed with N~5~-[2-(ethylsulfanyl)ethanimidoyl]-L-ornithine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, Nitric oxide synthase, ... | | Authors: | Li, H, Poulos, T.L. | | Deposit date: | 2009-09-11 | | Release date: | 2010-01-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
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1LRO
 | | Aquifex aeolicus KDO8P synthase H185G mutant in complex with PEP and Cadmium | | Descriptor: | CADMIUM ION, KDO-8-phosphate synthetase, PHOSPHATE ION, ... | | Authors: | Wang, J, Duewel, H.S, Stuckey, J.A, Woodard, R.W, Gatti, D.L. | | Deposit date: | 2002-05-15 | | Release date: | 2002-11-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Function of His185 in Aquifex aeolicus 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase
J.Mol.Biol., 324, 2002
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2ZLA
 | | 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure | | Descriptor: | (1R,2S,3R,5Z,7E)-17-{(1R)-1-[(2-ethyl-2-hydroxybutyl)sulfanyl]ethyl}-2-(2-hydroxyethoxy)-9,10-secoestra-5,7,16-triene-1,3-diol, Coactivator peptide DRIP, Vitamin D3 receptor | | Authors: | Shimizu, M, Miyamoto, Y, Nakabayashi, M, Masuno, H, Ikura, T, Ito, N. | | Deposit date: | 2008-04-04 | | Release date: | 2008-06-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure
Bioorg.Med.Chem., 16, 2008
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6PA8
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3JT5
 | | Structure of neuronal nitric oxide synthase heme domain complexed with N~5~-[2-(ethylsulfanyl)ethanimidoyl]-L-ornithine | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, Nitric oxide synthase, ... | | Authors: | Li, H, Poulos, T.L. | | Deposit date: | 2009-09-11 | | Release date: | 2010-01-12 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
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4C34
 | | PKA-S6K1 Chimera with Staurosporine bound | | Descriptor: | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, GLYCEROL, ... | | Authors: | Couty, S, Westwood, I.M, Kalusa, A, Cano, C, Travers, J, Boxall, K, Chow, C.L, Burns, S, Schmitt, J, Pickard, L, Barillari, C, McAndrew, P.C, Clarke, P.A, Linardopoulos, S, Griffin, R.J, Aherne, G.W, Raynaud, F.I, Workman, P, Jones, K, van Montfort, R.L.M. | | Deposit date: | 2013-08-21 | | Release date: | 2013-10-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design.
Oncotarget, 4, 2013
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1DM1
 | | 2.0 A CRYSTAL STRUCTURE OF THE DOUBLE MUTANT H(E7)V, T(E10)R OF MYOGLOBIN FROM APLYSIA LIMACINA | | Descriptor: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Federici, L, Savino, C, Musto, R, Travaglini-Allocatelli, C, Cutruzzola, F, Brunori, M. | | Deposit date: | 1999-12-13 | | Release date: | 2000-06-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Engineering His(E7) affects the control of heme reactivity in Aplysia limacina myoglobin.
Biochem.Biophys.Res.Commun., 269, 2000
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