2ZLA

2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure

Summary for 2ZLA

Entry DOI	10.2210/pdb2zla/pdb
Related	2ZL9 2ZLC
Descriptor	Vitamin D3 receptor, Coactivator peptide DRIP, (1R,2S,3R,5Z,7E)-17-{(1R)-1-[(2-ethyl-2-hydroxybutyl)sulfanyl]ethyl}-2-(2-hydroxyethoxy)-9,10-secoestra-5,7,16-triene-1,3-diol, ... (4 entities in total)
Functional Keywords	protein-ligand complex, dna-binding, metal-binding, nucleus, phosphoprotein, receptor, transcription, transcription regulation, zinc, zinc-finger, hormone
Biological source	Rattus norvegicus (Rat) More
Cellular location	Nucleus: P13053
Total number of polymer chains	2
Total formula weight	32660.66
Authors	Shimizu, M.,Miyamoto, Y.,Nakabayashi, M.,Masuno, H.,Ikura, T.,Ito, N. (deposition date: 2008-04-04, release date: 2008-06-24, Last modification date: 2023-11-01)
Primary citation	Shimizu, M.,Miyamoto, Y.,Takaku, H.,Matsuo, M.,Nakabayashi, M.,Masuno, H.,Udagawa, N.,DeLuca, H.F.,Ikura, T.,Ito, N. 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure Bioorg.Med.Chem., 16:6949-6964, 2008 Cited by PubMed: 18539034 DOI: 10.1016/j.bmc.2008.05.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation