7RFX
| Importin alpha2 in complex with MERS ORF4B | Descriptor: | Importin subunit alpha-1, ORF4b | Authors: | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-07-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
|
|
7RG2
| Importin alpha2 in complex with MERS ORF4B R33A mutant | Descriptor: | Importin subunit alpha-1, ORF4b | Authors: | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
|
|
7RG6
| Importin alpha2 in complex with ORF4B Bat coronavirus HKU5 | Descriptor: | Importin subunit alpha-1, Non-structural protein ORF4b | Authors: | Foster, J.K, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
|
|
7RG3
| Importin alpha2 in complex with MERS ORF4B R37A mutant | Descriptor: | Importin subunit alpha-1, ORF4b | Authors: | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
|
|
7RG4
| Importin alpha2 in complex with p50 NLS | Descriptor: | Importin subunit alpha-1, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | Authors: | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
|
|
7RG5
| Importin alpha3 in complex with p50 NLS | Descriptor: | Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | Authors: | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
|
|
8FUC
| Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein minor site NLS2 | Descriptor: | Contaminant peptide KKLARE, Importin subunit alpha-1, Matrix protein | Authors: | Donnelly, C.M, Basler, C.F, Scott, C, Forwood, J.K. | Deposit date: | 2023-01-17 | Release date: | 2023-01-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism. Viruses, 15, 2023
|
|
7RFZ
| Importin alpha 2 in complex with MERS ORF4B NLS peptide | Descriptor: | Importin subunit alpha-1, ORF4b | Authors: | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-07-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
|
|
1Z3H
| The exportin Cse1 in its cargo-free, cytoplasmic state | Descriptor: | Importin alpha re-exporter, MAGNESIUM ION | Authors: | Cook, A, Fernandez, E, Lindner, D, Ebert, J, Schlenstedt, G, Conti, E. | Deposit date: | 2005-03-12 | Release date: | 2005-05-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding Mol.Cell, 18, 2005
|
|
7JJL
| Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS | Descriptor: | Importin subunit alpha-3, Lysine-specific histone demethylase 1A | Authors: | Tu, W.J, McCuaig, R, Tan, H.Y.A, Hardy, K, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S. | Deposit date: | 2020-07-27 | Release date: | 2020-08-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Front Immunol, 11, 2020
|
|
6Q84
| Crystal structure of RanGTP-Pdr6-eIF5A export complex | Descriptor: | Eukaryotic translation initiation factor 5A-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Aksu, M, Trakhanov, S, Vera-Rodriguez, A, Gorlich, D. | Deposit date: | 2018-12-14 | Release date: | 2019-05-01 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
|
|
6Q82
| Crystal structure of the biportin Pdr6 in complex with RanGTP | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin beta-like protein KAP122, ... | Authors: | Aksu, M, Vera-Rodriguez, A, Trakhanov, S, Gorlich, D. | Deposit date: | 2018-12-14 | Release date: | 2019-05-01 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.994 Å) | Cite: | Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
|
|
8SV0
| |
4YI0
| Structure of mouse importin a1 bound to Pom121NLS | Descriptor: | Importin subunit alpha-1, Nuclear envelope pore membrane protein POM 121 | Authors: | Lokareddy, R.K, Cingolani, G. | Deposit date: | 2015-02-27 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.806 Å) | Cite: | Mammalian Pom121 and yeast Heh2 share IBB-like NLSs that support targeting to the inner nuclear membrane To Be Published
|
|
8U36
| |
5D5K
| |
6WX8
| SOX2 bound to Importin-alpha 3 | Descriptor: | Importin subunit alpha-3, SULFATE ION, Transcription factor SOX-2 | Authors: | Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. | Deposit date: | 2020-05-10 | Release date: | 2020-10-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
|
|
6WX9
| SOX2 bound to Importin-alpha 5 | Descriptor: | Importin subunit alpha-5, Transcription factor SOX-2 | Authors: | Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. | Deposit date: | 2020-05-10 | Release date: | 2020-10-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
|
|
6WX7
| SOX2 bound to Importin-alpha 2 | Descriptor: | Importin subunit alpha-1, Transcription factor SOX-2 | Authors: | Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. | Deposit date: | 2020-05-09 | Release date: | 2020-10-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
|
|
5H2X
| |
5H2W
| |
5H2V
| |
2BKU
| Kap95p:RanGTP complex | Descriptor: | GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN BETA-1 SUBUNIT, ... | Authors: | Lee, S.J, Matsuura, Y, Liu, S.M, Stewart, M. | Deposit date: | 2005-02-21 | Release date: | 2005-05-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Nuclear Import Complex Dissociation by Rangtp Nature, 435, 2005
|
|
5HUY
| |
5HUW
| |