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8AV0
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BU of 8av0 by Molmil
small molecule stabilizer (compound 1) for C-RAF pS259 and 14-3-3
Descriptor: 1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-08-26
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.
Acs Cent.Sci., 9, 2023
7OQG
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BU of 7oqg by Molmil
Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), BETA-MERCAPTOETHANOL, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-03
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7NMW
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BU of 7nmw by Molmil
Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 40
Descriptor: 14-3-3 protein sigma, 5-(2-azanylethyl)-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-02-23
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Fragment-based exploration of the 14-3-3/Amot-p130 interface.
Curr Res Struct Biol, 4, 2022
6Y8A
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BU of 6y8a by Molmil
14-3-3 Sigma in complex with phosphorylated camkk2{pS511} peptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Calcium/calmodulin-dependent protein kinase kinase 2, ...
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-03-04
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.
Acta Crystallogr.,Sect.F, 76, 2020
6Y3R
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BU of 6y3r by Molmil
14-3-3 Sigma in complex with phosphorylated (Thr391) Gab2 peptide
Descriptor: 14-3-3 protein sigma, Chain P, MAGNESIUM ION
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-02-18
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.
Acta Crystallogr.,Sect.F, 76, 2020
7AOG
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BU of 7aog by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C.
Deposit date:2020-10-14
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
6Y3M
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BU of 6y3m by Molmil
14-3-3 Sigma in complex with phosphorylated ATPase peptide
Descriptor: 14-3-3 protein sigma, ATPase peptide, CALCIUM ION, ...
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-02-18
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.
Acta Crystallogr.,Sect.F, 76, 2020
6FBY
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BU of 6fby by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 4.2b with 14-3-3sigma
Descriptor: (2~{R})-2-[(~{S})-(3-methylphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ...
Authors:Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G.
Deposit date:2017-12-20
Release date:2018-05-16
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018
6Y3O
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BU of 6y3o by Molmil
14-3-3 Sigma in complex with phosphorylated CAMKK2 peptide
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CAMKK2, ...
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-02-18
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.
Acta Crystallogr.,Sect.F, 76, 2020
8EQ8
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BU of 8eq8 by Molmil
The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y130
Descriptor: 14-3-3 protein beta/alpha
Authors:Zhu, P, Cooley, R.B.
Deposit date:2022-10-07
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation.
Protein Sci., 32, 2023
2O02
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BU of 2o02 by Molmil
Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, ExoS (416-430) peptide
Authors:Ottmann, C, Yasmin, L, Weyand, M, Hauser, A.R, Wittinghofer, A, Hallberg, B.
Deposit date:2006-11-27
Release date:2007-11-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis
Embo J., 26, 2007
6Y8D
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BU of 6y8d by Molmil
14-3-3 Sigma in complex with phosphorylated caspase{pS164} peptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-03-04
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.
Acta Crystallogr.,Sect.F, 76, 2020
6ZCJ
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BU of 6zcj by Molmil
14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376
Authors:Soini, L, Leysen, S, Davis, J, Ottmann, C.
Deposit date:2020-06-11
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.
Febs Lett., 595, 2021
8BZF
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BU of 8bzf by Molmil
FC-J acetonide stabilizer of 14-3-3 and ERalpha
Descriptor: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin J-acetonide, ...
Authors:Visser, E.J, Ottmann, C.
Deposit date:2022-12-14
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
6RWS
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BU of 6rws by Molmil
Fragment AZ-009 binding at the p53pT387/14-3-3 sigma interface
Descriptor: 14-3-3 protein sigma, 4-chloranyl-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide, Cellular tumor antigen p53, ...
Authors:Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C.
Deposit date:2019-06-06
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
6Y8B
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BU of 6y8b by Molmil
14-3-3 Sigma in complex with phosphorylated caspase{pS139} peptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-03-04
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.
Acta Crystallogr.,Sect.F, 76, 2020
6RJZ
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BU of 6rjz by Molmil
Fragment AZ-015 binding at the p53pT387/14-3-3 sigma interface
Descriptor: 14-3-3 protein sigma, 7-(6-azanylpyridin-2-yl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ...
Authors:Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C.
Deposit date:2019-04-29
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
7NJ6
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BU of 7nj6 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1005
Descriptor: 14-3-3 protein sigma, 4-[4-(trifluoromethyl)imidazol-1-yl]benzaldehyde, CALCIUM ION, ...
Authors:Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C.
Deposit date:2021-02-16
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7B15
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BU of 7b15 by Molmil
14-3-3sigma in complex with SHN3pT869 phosphopeptide crystal structure
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pT869
Authors:Soini, L, Leysen, S, Davis, J, Ottmann, C.
Deposit date:2020-11-23
Release date:2021-09-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:14-3-3 sigma in complex with phosphopeptides
To Be Published
6F09
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BU of 6f09 by Molmil
Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide
Descriptor: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8
Authors:Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S.
Deposit date:2017-11-17
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.594 Å)
Cite:Biophysical and structural insight into the USP8/14-3-3 interaction.
FEBS Lett., 592, 2018
8AQE
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BU of 8aqe by Molmil
Small molecular stabilizer for ERalpha and 14-3-3 (1080295)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-N-[7-[4-[(4-chlorophenyl)amino]oxan-4-yl]carbonyl-7-azaspiro[3.5]nonan-2-yl]ethanamide, Estrogen receptor, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-08-12
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023
8ARO
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BU of 8aro by Molmil
Small molecular stabilizer for ERalpha and 14-3-3 (1080291)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-N-[[1-[2-[(4-chlorophenyl)amino]-2-methyl-propanoyl]piperidin-4-yl]methyl]ethanamide, Estrogen receptor, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-08-17
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023
8AXU
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BU of 8axu by Molmil
Small molecule stabilizer for ERalpha and 14-3-3 (1075297)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[1-(4-chloranylphenoxy)cyclopentyl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ...
Authors:Konstantinidou, M, Visser, E.J, Vandenboorn, E.M.F, Sheng, C, Jaishankar, P, Overmans, M.J.A.M, Dutta, S, Neitz, J, Renslo, A, Ottmann, C, Brunsveld, L, Arkin, M.
Deposit date:2022-09-01
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023
8AZE
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BU of 8aze by Molmil
Small molecule stabilizer for ERalpha and 14-3-3 (1075306)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[1-[(4-chlorophenyl)amino]cyclopentyl]carbonylpiperidin-4-yl]methyl]ethanamide, ERalpha peptide, ...
Authors:Konstantinidou, M, Visser, E.J, Vandenboorn, E.M.F, Sheng, C, Jaishankar, P, Overmans, M.J.A.M, Dutta, S, Neitz, J, Renslo, A, Ottmann, C, Brunsveld, L, Arkin, M.
Deposit date:2022-09-06
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023
8AV4
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BU of 8av4 by Molmil
Small molecular stabilizer for ERalpha and 14-3-3 (1075305)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[4-(4-chloranylphenoxy)oxan-4-yl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-08-26
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023

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數據於2024-06-26公開中

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