8CYG
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8RU3
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![BU of 8ru3 by Molmil](/molmil-images/mine/8ru3) | Crystal structure of beta-catenin in complex with alpha-helical peptide inhibitor | Descriptor: | Axin-1, CHLORIDE ION, Catenin beta-1 | Authors: | Yeste Vazquez, A, Klintrot, C.I.R, Grossmann, T.N, Hennig, S. | Deposit date: | 2024-01-30 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene beta-Catenin. Angew.Chem.Int.Ed.Engl., 2024
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6V0L
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![BU of 6v0l by Molmil](/molmil-images/mine/6v0l) | PDGFR-b Promoter Forms a G-Vacancy Quadruplex that Can be Complemented by dGMP: Molecular Structure and Recognition of Guanine Derivatives and Metabolites | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*(3D1)P*AP*GP*GP*GP*AP*GP*GP*GP*CP*GP*GP*CP*GP*GP*GP*AP*CP*A)-3') | Authors: | Wang, K.B, Dickerhoff, J, Wu, G, Yang, D. | Deposit date: | 2019-11-18 | Release date: | 2020-03-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | PDGFR-beta Promoter Forms a Vacancy G-Quadruplex that Can Be Filled in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs. J.Am.Chem.Soc., 142, 2020
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1C0O
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6UZ0
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![BU of 6uz0 by Molmil](/molmil-images/mine/6uz0) | Cardiac sodium channel with flecainide | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Jiang, D, Shi, H, Tonggu, L, Lenaeus, M.J, Zheng, N, Catterall, W.A. | Deposit date: | 2019-11-14 | Release date: | 2020-01-01 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structure of the Cardiac Sodium Channel. Cell, 180, 2020
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6V1I
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![BU of 6v1i by Molmil](/molmil-images/mine/6v1i) | Cryo-EM reconstruction of the thermophilic bacteriophage P74-26 small terminase- symmetric | Descriptor: | Small terminase protein | Authors: | Hayes, J.A, Hilbert, B.J, Gaubitz, C, Stone, N.P, Kelch, B.A. | Deposit date: | 2019-11-20 | Release date: | 2020-02-12 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry. J.Biol.Chem., 295, 2020
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5IRT
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2BY4
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![BU of 2by4 by Molmil](/molmil-images/mine/2by4) | SR Ca(2+)-ATPase in the HnE2 state complexed with the thapsigargin derivative Boc-12ADT. | Descriptor: | (3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL 12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Jensen, A.L, Moller, J.V, Soehoel, H, Denmeade, S.R, Isaacs, J.T, Olsen, C.E, Christensen, S.B, Nissen, P. | Deposit date: | 2005-07-28 | Release date: | 2006-04-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Natural Products as Starting Materials for Development of Second-Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells Bioorg.Med.Chem., 14, 2006
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6PPT
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6VCC
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![BU of 6vcc by Molmil](/molmil-images/mine/6vcc) | Cryo-EM structure of the Dvl2 DIX filament | Descriptor: | Segment polarity protein dishevelled homolog DVL-2 | Authors: | Enos, M, Kan, W, Muennich, S, Chen, D.H, Skiniotis, G, Weis, W.I. | Deposit date: | 2019-12-20 | Release date: | 2020-04-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/ beta-catenin signal transduction. Elife, 9, 2020
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1BTO
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5J7J
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1C0G
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![BU of 1c0g by Molmil](/molmil-images/mine/1c0g) | CRYSTAL STRUCTURE OF 1:1 COMPLEX BETWEEN GELSOLIN SEGMENT 1 AND A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 228: Q228K/T229A/A230Y/E360H) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, PROTEIN (CHIMERIC ACTIN), ... | Authors: | Matsuura, Y, Stewart, M, Kawamoto, M, Kamiya, N, Saeki, K, Yasunaga, T, Wakabayashi, T. | Deposit date: | 1999-07-16 | Release date: | 2000-03-01 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the higher Ca(2+)-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras. J.Mol.Biol., 296, 2000
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1BTL
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![BU of 1btl by Molmil](/molmil-images/mine/1btl) | CRYSTAL STRUCTURE OF ESCHERICHIA COLI TEM1 BETA-LACTAMASE AT 1.8 ANGSTROMS RESOLUTION | Descriptor: | BETA-LACTAMASE TEM1, SULFATE ION | Authors: | Jelsch, C, Mourey, L, Masson, J.M, Samama, J.P. | Deposit date: | 1993-11-01 | Release date: | 1995-01-26 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of Escherichia coli TEM1 beta-lactamase at 1.8 A resolution. Proteins, 16, 1993
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6VAO
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![BU of 6vao by Molmil](/molmil-images/mine/6vao) | Human cofilin-1 decorated actin filament | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Huehn, A.R, Bibeau, J.P, Schramm, A.C, Cao, W, De La Cruz, E.M, Sindelar, C.V. | Deposit date: | 2019-12-17 | Release date: | 2020-01-08 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments. Proc.Natl.Acad.Sci.USA, 117, 2020
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8WKQ
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![BU of 8wkq by Molmil](/molmil-images/mine/8wkq) | Cryo-EM structure of the MS ring (C1) with export apparatus and proximal rod within the flagellar motor-hook complex in the CW state. | Descriptor: | Flagellar M-ring protein, Flagellar basal body rod protein FlgB, Flagellar basal-body rod protein FlgC, ... | Authors: | Tan, J.X, Zhang, L, Zhou, Y, Zhu, Y.Q. | Deposit date: | 2023-09-28 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structure of the MS ring (C1) with export apparatus and proximal rod within the flagellar motor-hook complex in the CW state. To Be Published
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8WIW
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![BU of 8wiw by Molmil](/molmil-images/mine/8wiw) | Cryo-EM structure of the flagellar C ring in the CW state | Descriptor: | Chemotaxis protein CheY, Flagellar M-ring protein, Flagellar motor switch protein FliG, ... | Authors: | Tan, J.X, Zhang, L, Zhou, Y, Zhu, Y.Q. | Deposit date: | 2023-09-25 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Cryo-EM structure of the flagellar C ring in the CW state To Be Published
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8WOE
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![BU of 8woe by Molmil](/molmil-images/mine/8woe) | Cryo-EM structure of the intact flagellar motor-hook complex in the CW state | Descriptor: | Chemotaxis protein CheY, Flagellar L-ring protein, Flagellar M-ring protein, ... | Authors: | Tan, J.X, Zhang, L, Zhou, Y, Zhu, Y.Q. | Deposit date: | 2023-10-07 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structure of the intact flagellar motor-hook complex in the CW state To Be Published
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6PQ2
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8V1Q
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![BU of 8v1q by Molmil](/molmil-images/mine/8v1q) | Herpes simplex virus 1 polymerase holoenzyme bound to DNA in both open/closed conformations | Descriptor: | DNA polymerase, DNA polymerase processivity factor, MAGNESIUM ION, ... | Authors: | Pan, J, Abraham, J, Coen, D.M, Shankar, S, Yang, P, Hogle, J. | Deposit date: | 2023-11-21 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Viral DNA polymerase structures reveal mechanisms for drug selectivity Cell(Cambridge,Mass.), 2024
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8V1T
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![BU of 8v1t by Molmil](/molmil-images/mine/8v1t) | Herpes simplex virus 1 polymerase holoenzyme bound to DNA and acyclovir triphosphate in closed conformation | Descriptor: | ACYCLOVIR TRIPHOSPHATE, DNA polymerase, DNA polymerase processivity factor, ... | Authors: | Pan, J, Abraham, J, Coen, D.M, Shankar, S, Yang, P, Hogle, J. | Deposit date: | 2023-11-21 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Viral DNA polymerase structures reveal mechanisms for drug selectivity Cell(Cambridge,Mass.), 2024
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8WK4
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8VPN
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![BU of 8vpn by Molmil](/molmil-images/mine/8vpn) | Phosphorylated human NCC in complex with indapamide | Descriptor: | 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | Authors: | Zhao, Y.X, Cao, E.H. | Deposit date: | 2024-01-16 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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6URS
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![BU of 6urs by Molmil](/molmil-images/mine/6urs) | Sleeping Beauty transposase PAI subdomain mutant - H19Y | Descriptor: | Sleeping Beauty transposase PAI subdomain | Authors: | Nesmelova, I.V, Leighton, G.O, Yan, C, Lustig, J, Corona, R.I, Guo, J.T, Ivics, Z. | Deposit date: | 2019-10-24 | Release date: | 2020-10-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | H19Y mutation in the primary DNA-recognition subdomain of the Sleeping Beauty transposase improves structural stability, transposon DNA-binding and transposition To Be Published
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1B6Q
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