6SUK
| Crystal structure of Neprilysin in complex with Omapatrilat. | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | Authors: | Cozier, G.E, Acharya, K.R, Sharma, U. | Deposit date: | 2019-09-15 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme. J.Med.Chem., 63, 2020
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2O1H
| Naturally occurring mutation of Humna ABO(H) Galactosyltransferase in complex with UDP: GTB/M214T_UDP | Descriptor: | ABO glycosyltransferase, MANGANESE (II) ION, MERCURY (II) ION, ... | Authors: | Letts, J.A, Borisova, S.N, Evans, S.V. | Deposit date: | 2006-11-28 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif. J.Biol.Chem., 282, 2007
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4AKG
| Dynein Motor Domain - ATP complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, GLUTATHIONE S-TRANSFERASE CLASS-MU 26 KDA ISOZYME, ... | Authors: | Schmidt, H, Gleave, E.S, Carter, A.P. | Deposit date: | 2012-02-22 | Release date: | 2012-03-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Insights Into Dynein Motor Domain Function from a 3.3 Angstrom Crystal Structure Nat.Struct.Mol.Biol., 19, 2012
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2O1U
| Structure of full length GRP94 with AMP-PNP bound | Descriptor: | Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. | Deposit date: | 2006-11-29 | Release date: | 2007-10-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Mol.Cell, 28, 2007
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6SK3
| C-terminal HsNMT1 deltaC3 truncation in complex with both MyrCoA and GNCFSKPR substrates | Descriptor: | Apoptosis-inducing factor 3, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ... | Authors: | Dian, C, Riviere, F.B, Asensio, T, Giglione, C, Meinnel, T. | Deposit date: | 2019-08-14 | Release date: | 2020-03-18 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nat Commun, 11, 2020
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3CSJ
| Human glutathione s-transferase p1-1 in complex with chlorambucil | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORAMBUCIL, CHLORIDE ION, ... | Authors: | Parker, L.J. | Deposit date: | 2008-04-09 | Release date: | 2008-07-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants. J.Mol.Biol., 380, 2008
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2NSE
| BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE SUBSTRATE COMPLEX | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, CACODYLATE ION, ... | Authors: | Raman, C.S, Li, H, Martasek, P, Kral, V, Masters, B.S.S, Poulos, T.L. | Deposit date: | 1998-08-13 | Release date: | 1999-05-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell(Cambridge,Mass.), 95, 1998
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6SZ3
| Crystal structure of YTHDC1 with fragment 4 (DHU_DC1_158) | Descriptor: | SULFATE ION, YTH domain-containing protein 1, ~{N}-methyl-5,6,7,8-tetrahydroquinolin-4-amine | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-01 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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2NTB
| Crystal structure of pectin methylesterase in complex with hexasaccharide V | Descriptor: | Pectinesterase A, alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid | Authors: | Fries, M, Brocklehurst, K, Shevchik, V.E, Pickersgill, R.W. | Deposit date: | 2006-11-07 | Release date: | 2007-09-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis of the activity of the phytopathogen pectin methylesterase. Embo J., 26, 2007
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6T03
| Crystal structure of YTHDC1 with fragment 16 (DHU_DC1_017) | Descriptor: | 1,3-dihydroimidazole-2-thione, SULFATE ION, YTHDC1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6STY
| Human REXO2 exonuclease in complex with RNA. | Descriptor: | CALCIUM ION, Oligoribonuclease, mitochondrial, ... | Authors: | Malik, D, Szewczyk, M, Szczesny, R, Nowotny, M. | Deposit date: | 2019-09-12 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA. Nucleic Acids Res., 48, 2020
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6SVE
| Protein allostery of the WW domain at atomic resolution: pCdc25C bound structure | Descriptor: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Authors: | Strotz, D, Orts, J, Friedmann, M, Guntert, P, Vogeli, B, Riek, R. | Deposit date: | 2019-09-18 | Release date: | 2020-10-07 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Protein Allostery at Atomic Resolution. Angew.Chem.Int.Ed.Engl., 59, 2020
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3CWA
| Crystal Structure of an AlkA Host/Guest Complex 8oxoGuanine:Cytosine Base Pair | Descriptor: | DNA (5'-D(*(8OG)P*DAP*DCP*DAP*DTP*DGP*DAP*DGP*DTP*DGP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DCP*DAP*DCP*DTP*DCP*DAP*DTP*DGP*DTP*DC)-3'), DNA-3-methyladenine glycosylase 2 | Authors: | Bowman, B.R, Lee, S, Wang, S, Verdine, G.L. | Deposit date: | 2008-04-21 | Release date: | 2008-09-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA. Structure, 16, 2008
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2O7L
| The open-cap conformation of GlpG | Descriptor: | Protein glpG, nonyl beta-D-glucopyranoside | Authors: | Ha, Y. | Deposit date: | 2006-12-11 | Release date: | 2006-12-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Open-cap conformation of intramembrane protease GlpG. Proc.Natl.Acad.Sci.Usa, 104, 2007
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3D4V
| Crystal Structure of an AlkA Host/Guest Complex N7MethylGuanine:Cytosine Base Pair | Descriptor: | 5'-D(*DGP*DAP*DCP*DAP*DTP*DGP*DAP*(FMG)P*DTP*DGP*DCP*DC)-3', 5'-D(*DGP*DGP*DCP*DAP*DCP*DTP*DCP*DAP*DTP*DGP*DTP*DC)-3', DNA-3-methyladenine glycosylase 2 | Authors: | Lee, S, Bowman, B.R, Wang, S, Verdine, G.L. | Deposit date: | 2008-05-15 | Release date: | 2008-09-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J.Am.Chem.Soc., 130, 2008
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6SZ7
| Crystal structure of YTHDC1 with fragment 5 (DHU_DC1_066) | Descriptor: | 5,6,7,8-tetrahydro-4~{a}~{H}-quinazoline-2,4-dione, SULFATE ION, YTH domain-containing protein 1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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2NSH
| E. coli PurE H45Q mutant complexed with nitro-AIR | Descriptor: | ((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE, Phosphoribosylaminoimidazole carboxylase catalytic subunit | Authors: | Ealick, S.E, Morar, M. | Deposit date: | 2006-11-04 | Release date: | 2007-04-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis. Biochemistry, 46, 2007
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6MW3
| EM structure of Bacillus subtilis ribonucleotide reductase inhibited filament composed of NrdE alpha subunit and NrdF beta subunit with dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase, Ribonucleoside-diphosphate reductase NrdF beta subunit | Authors: | Thomas, W.C, Bacik, J.P, Kaelber, J.T, Ando, N. | Deposit date: | 2018-10-29 | Release date: | 2019-06-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.65 Å) | Cite: | Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
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6SZR
| Crystal structure of YTHDC1 with fragment 9 (DHU_DC1_107) | Descriptor: | 6-[[methyl-(phenylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione, SULFATE ION, YTH domain-containing protein 1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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2NRF
| Crystal Structure of GlpG, a Rhomboid family intramembrane protease | Descriptor: | Protein GlpG | Authors: | Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y. | Deposit date: | 2006-11-02 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat.Struct.Mol.Biol., 13, 2006
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6SZX
| Crystal structure of YTHDC1 with fragment 11 (DHU_DC1_128) | Descriptor: | 6-[[cyclopropyl-(phenylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6T06
| Crystal structure of YTHDC1 with fragment 19 (DHU_DC1_045) | Descriptor: | 3-imidazolidin-2-yl-2~{H}-indazole, SULFATE ION, YTHDC1 | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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3FAW
| Crystal Structure of the Group B Streptococcus Pullulanase SAP | Descriptor: | CALCIUM ION, CHLORIDE ION, Reticulocyte binding protein | Authors: | Gourlay, L.J. | Deposit date: | 2008-11-18 | Release date: | 2009-04-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Group B Streptococcus pullulanase crystal structures in the context of a novel strategy for vaccine development J.Bacteriol., 191, 2009
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6T0C
| Crystal structure of YTHDC1 with fragment 26 (DHU_DC1_198) | Descriptor: | SULFATE ION, YTHDC1, ~{N}-methyl-2~{H}-indazole-3-carboxamide | Authors: | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | Deposit date: | 2019-10-02 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6NJR
| Spin-Labeled T177C/A637C Mutant of Rat CYPOR | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Xia, C, Kim, J.J.K. | Deposit date: | 2019-01-04 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase. Biochemistry, 58, 2019
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