6TOL
 
 | | Crystal structure of human BCL6 BTB domain in complex with compound 25a | | Descriptor: | 1,2-ETHANEDIOL, 5-[[5-chloranyl-2-[(2~{S},6~{R})-2,6-dimethylmorpholin-4-yl]pyrimidin-4-yl]amino]-1-methyl-3-(3-methyl-3-oxidanyl-butyl)benzimidazol-2-one, B-cell lymphoma 6 protein, ... | | Authors: | Rodrigues, M.J, Le Bihan, Y.-V, van Montfort, R.L.M. | | Deposit date: | 2019-12-11 | | Release date: | 2020-04-22 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
J.Med.Chem., 63, 2020
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6TOJ
 | | Crystal structure of human BCL6 BTB domain in complex with compound 17a | | Descriptor: | 1,2-ETHANEDIOL, 2-chloranyl-4-[[1-methyl-3-(3-methyl-3-oxidanyl-butyl)-2-oxidanylidene-benzimidazol-5-yl]amino]pyridine-3-carbonitrile, B-cell lymphoma 6 protein | | Authors: | Rodrigues, M.J, Le Bihan, Y.-V, van Montfort, R.L.M. | | Deposit date: | 2019-12-11 | | Release date: | 2020-04-22 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
J.Med.Chem., 63, 2020
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3K33
 | | Crystal structure of the Phd-Doc complex | | Descriptor: | ACETATE ION, Death on curing protein, Polypeptide of unknown amino acids and source, ... | | Authors: | Loris, R, Garcia-Pino, A. | | Deposit date: | 2009-10-01 | | Release date: | 2010-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.
Cell(Cambridge,Mass.), 142, 2010
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5Z28
 | | AtVAL2 PHD-Like domain | | Descriptor: | B3 domain-containing transcription repressor VAL2, GLYCEROL, ZINC ION | | Authors: | Wu, B.X, Zhang, M.M. | | Deposit date: | 2017-12-30 | | Release date: | 2018-05-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.245 Å) | | Cite: | Crystal structure of AtVAL12 PHD-Like domain
To Be Published
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3MW6
 | | Crystal structure of NMB1681 from Neisseria meningitidis MC58, a FinO-like RNA chaperone | | Descriptor: | GLYCEROL, uncharacterized protein NMB1681 | | Authors: | Tan, K, Zhou, M, Duggan, E, Abdullah, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2010-05-05 | | Release date: | 2010-06-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.209 Å) | | Cite: | N. meningitidis 1681 is a member of the FinO family of RNA chaperones.
Rna Biol., 7, 2010
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6A2Q
 | | Mycobacterium tuberculosis LexA C-domain I | | Descriptor: | GLYCEROL, LexA repressor | | Authors: | Chandran, A.V, Srikalaivani, R, Paul, A, Vijayan, M. | | Deposit date: | 2018-06-12 | | Release date: | 2019-01-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment.
Acta Crystallogr D Struct Biol, 75, 2019
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2CA9
 | | apo-NIKR from helicobacter pylori in closed trans-conformation | | Descriptor: | FORMIC ACID, GLYCEROL, PUTATIVE NICKEL-RESPONSIVE REGULATOR | | Authors: | Dian, C, Schauer, K, Kapp, U, McSweeney, S.M, Labigne, A, Terradot, L. | | Deposit date: | 2005-12-20 | | Release date: | 2006-07-17 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural Basis of the Nickel Response in Helicobacter Pylori: Crystal Structures of Hpnikr in Apo and Nickel-Bound States.
J.Mol.Biol., 361, 2006
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2CAD
 | | NikR from Helicobacter pylori in closed trans-conformation and nickel bound to 2F, 2X and 2I sites. | | Descriptor: | CITRIC ACID, FORMIC ACID, GLYCEROL, ... | | Authors: | Dian, C, Schauer, K, Kapp, U, McSweeney, S.M, Labigne, A, Terradot, L. | | Deposit date: | 2005-12-20 | | Release date: | 2006-07-17 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis of the Nickel Response in Helicobacter Pylori: Crystal Structures of Hpnikr in Apo and Nickel-Bound States.
J.Mol.Biol., 361, 2006
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6A2R
 | | Mycobacterium tuberculosis LexA C-domain II | | Descriptor: | DI(HYDROXYETHYL)ETHER, LexA repressor | | Authors: | Chandran, A.V, Srikalaivani, R, Paul, A, Vijayan, M. | | Deposit date: | 2018-06-12 | | Release date: | 2019-01-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment.
Acta Crystallogr D Struct Biol, 75, 2019
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2N3A
 | | Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404) | | Descriptor: | PC4 and SFRS1-interacting protein, Pogo transposable element with ZNF domain | | Authors: | Tesina, P, Cermakova, K, Horejsi, M, Prochazkova, K, Fabry, M, Sharma, S, Christ, F, Demeulemeester, J, Debyser, Z, De Rijck, J, Veverka, V, Rezacova, P. | | Deposit date: | 2015-05-26 | | Release date: | 2015-08-19 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
Nat Commun, 6, 2015
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6CHV
 | | Proteus vulgaris HigA antitoxin bound to DNA | | Descriptor: | Antitoxin HigA, MAGNESIUM ION, pHigCryst3, ... | | Authors: | Schureck, M.A, Hoffer, E.D, Onuoha, N, Dunham, C.M. | | Deposit date: | 2018-02-23 | | Release date: | 2019-02-27 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of transcriptional regulation by the HigA antitoxin.
Mol.Microbiol., 111, 2019
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1K0B
 | | Ure2p in Complex with Glutathione | | Descriptor: | GLUTATHIONE, URE2 PROTEIN | | Authors: | Bousset, L, Belrhali, H, Melki, R, Morera, S. | | Deposit date: | 2001-09-19 | | Release date: | 2001-12-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of the yeast prion Ure2p functional region in complex with glutathione and related compounds.
Biochemistry, 40, 2001
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5OJX
 | | Crystal structure of regulator protein 2 (PamR2) from the pamamycin biosynthetic gene cluster of Streptomyces alboniger | | Descriptor: | TetR family transcription regulator | | Authors: | Schmelz, S, Rebets, Y, Luzhetskyy, A, Scrima, A. | | Deposit date: | 2017-07-24 | | Release date: | 2018-04-11 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Design, development and application of whole-cell based antibiotic-specific biosensor.
Metab. Eng., 47, 2018
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7F70
 | | Crystal structure of Rv3094c | | Descriptor: | Rv3094c | | Authors: | Wang, Z.X, Ouyang, S.Y, Zhang, H.T. | | Deposit date: | 2021-06-26 | | Release date: | 2022-06-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene.
Commun Biol, 6, 2023
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7F74
 | | Rv3094c in complex with FMN. | | Descriptor: | FLAVIN MONONUCLEOTIDE, Rv3094c | | Authors: | Wang, Z.X, Ouyang, S.Y. | | Deposit date: | 2021-06-27 | | Release date: | 2022-06-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene.
Commun Biol, 6, 2023
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7F72
 | | Rv3094c in complex with FAD and ETH. | | Descriptor: | 2-ethylpyridine-4-carboximidothioic acid, FLAVIN MONONUCLEOTIDE, Rv3094c | | Authors: | Wang, Z.X, Ouyang, S.Y. | | Deposit date: | 2021-06-27 | | Release date: | 2022-07-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene.
Commun Biol, 6, 2023
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1K0C
 | | Ure2p in complex with S-p-nitrobenzylglutathione | | Descriptor: | GLUTATHIONE, S-(P-NITROBENZYL)GLUTATHIONE, URE2 PROTEIN | | Authors: | Bousset, L, Belrhali, H, Melki, R, Morera, S. | | Deposit date: | 2001-09-19 | | Release date: | 2001-12-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of the yeast prion Ure2p functional region in complex with glutathione and related compounds.
Biochemistry, 40, 2001
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1K0A
 | | Ure2p in Complex with S-hexylglutathione | | Descriptor: | GLUTATHIONE, S-HEXYLGLUTATHIONE, URE2 PROTEIN | | Authors: | Bousset, L, Belrhali, H, Melki, R, Morera, S. | | Deposit date: | 2001-09-19 | | Release date: | 2001-12-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of the yeast prion Ure2p functional region in complex with glutathione and related compounds.
Biochemistry, 40, 2001
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5OS9
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1HW2
 | | FADR-DNA COMPLEX: TRANSCRIPTIONAL CONTROL OF FATTY ACID METABOLISM IN ECHERICHIA COLI | | Descriptor: | 5'-D(*CP*GP*AP*TP*CP*TP*GP*GP*TP*CP*CP*GP*AP*CP*CP*AP*GP*AP*TP*GP*CP*T)-3', 5'-D(*G*CP*AP*TP*CP*TP*GP*GP*TP*CP*GP*GP*AP*CP*CP*AP*GP*AP*TP*CP*GP*A)-3', FATTY ACID METABOLISM REGULATOR PROTEIN, ... | | Authors: | Xu, Y, Heath, R.J, Li, Z, Rock, C.O, White, S.W. | | Deposit date: | 2001-01-09 | | Release date: | 2001-01-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli.
J.Biol.Chem., 276, 2001
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4NUF
 | | Crystal Structure of SHP/EID1 | | Descriptor: | EID1 peptide, Maltose ABC transporter periplasmic protein, Nuclear receptor subfamily 0 group B member 2 chimeric construct, ... | | Authors: | Zhi, X, Zhou, X.E, He, Y, Zechner, C, Suino-Powell, K.M, Kliewer, S.A, Melcher, K, Mangelsdorf, D.J, Xu, H.E. | | Deposit date: | 2013-12-03 | | Release date: | 2014-01-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural insights into gene repression by the orphan nuclear receptor SHP.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5X4N
 | | Crystal structure of the BCL6 BTB domain in complex with Compound 4 | | Descriptor: | 1,2-ETHANEDIOL, 5-chloro-N4-phenylpyrimidine-2,4-diamine, B-cell lymphoma 6 protein | | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | | Deposit date: | 2017-02-13 | | Release date: | 2017-05-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
J. Med. Chem., 60, 2017
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5OJY
 | | Co-complex structure of regulator protein 2 (PamR2) with pamamycin 607 from Streptomyces alboniger | | Descriptor: | CITRIC ACID, GLYCEROL, Pamamycin 607, ... | | Authors: | Schmelz, S, Rebets, Y, Luzhetskyy, A, Scrima, A. | | Deposit date: | 2017-07-24 | | Release date: | 2018-04-11 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.851 Å) | | Cite: | Design, development and application of whole-cell based antibiotic-specific biosensor.
Metab. Eng., 47, 2018
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5X4O
 | | Crystal structure of the BCL6 BTB domain in complex with Compound 5 | | Descriptor: | B-cell lymphoma 6 protein, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | | Deposit date: | 2017-02-13 | | Release date: | 2017-05-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
J. Med. Chem., 60, 2017
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2IT0
 | | Crystal structure of a two-domain IdeR-DNA complex crystal form II | | Descriptor: | ACETATE ION, Iron-dependent repressor ideR, NICKEL (II) ION, ... | | Authors: | Wisedchaisri, G, Chou, C.J, Wu, M, Roach, C, Rice, A.E, Holmes, R.K, Beeson, C, Hol, W.G. | | Deposit date: | 2006-10-18 | | Release date: | 2007-02-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis
Biochemistry, 46, 2007
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