7DCF
 
 | | Crystal structure of EHMT2 SET domain in complex with compound 10 | | Descriptor: | 5'-methoxy-6'-(1-methyl-2,3,4,7-tetrahydroazepin-5-yl)spiro[cyclobutane-1,3'-indole]-2'-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... | | Authors: | Suzuki, M, Katayama, K. | | Deposit date: | 2020-10-26 | | Release date: | 2021-02-10 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating beta-Thalassemia and Sickle Cell Disease.
Acs Med.Chem.Lett., 12, 2021
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7D28
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1W6H
 | | Novel plasmepsin II-inhibitor complex | | Descriptor: | N-((3S,4S)-5-[(4-BROMOBENZYL)OXY]-3-HYDROXY-4-{[N-(PYRIDIN-2-YLCARBONYL)-L-VALYL]AMINO}PENTANOYL)-L-ALANYL-L-LEUCINAMIDE, PLASMEPSIN 2 | | Authors: | Lindberg, J, Johansson, P.-O, Rosenquist, A, Kvarnstroem, I, Vrang, L, Samuelsson, B, Unge, T. | | Deposit date: | 2004-08-18 | | Release date: | 2006-07-05 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structural Study of a Novel Inhibitor with Bulky P1 Side Chain in Complex with Plasmepsin II -Implications for Drug Design
To be Published
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6RAJ
 | | Heterodimeric ABC exporter TmrAB in vanadate trapped outward-facing open conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, MAGNESIUM ION, ... | | Authors: | Thomas, C, Januliene, D, Mehdipour, A.R, Hofmann, S, Hummer, G, Moeller, A, Tampe, R. | | Deposit date: | 2019-04-06 | | Release date: | 2019-07-31 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
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6RAW
 | | D. melanogaster CMG-DNA, State 1A | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AT18545p, ... | | Authors: | Eickhoff, P, Martino, F, Costa, A. | | Deposit date: | 2019-04-08 | | Release date: | 2019-09-11 | | Last modified: | 2019-09-18 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Cell Rep, 28, 2019
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7D2Q
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7D58
 | | cryo-EM structure of human RNA polymerase III in elongating state | | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | Authors: | Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2020-09-25 | | Release date: | 2021-02-17 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into transcriptional regulation of human RNA polymerase III.
Nat.Struct.Mol.Biol., 28, 2021
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7NN6
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6RCO
 | | PfRH5-binding monoclonal antibody R5.004 | | Descriptor: | ACETATE ION, GLYCEROL, R5.004 heavy chain, ... | | Authors: | Alanine, D.G.W, Draper, S.J, Higgins, M.K. | | Deposit date: | 2019-04-11 | | Release date: | 2019-06-26 | | Last modified: | 2019-08-21 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
Cell, 178, 2019
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7D2P
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7D5C
 | | IleRS in complex with a tRNA site inhibitor | | Descriptor: | (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-9-methyl-2-[(1E,3E)-3-methyl-5-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-3-(4-oxidanyl-4-oxidanylidene-butanoyl)oxy-1,7-dioxaspiro[5.5]undecan-8-yl]-4,8-dimethyl-5-oxidanyl-deca-2,6,8-trienoic acid, 1,2-ETHANEDIOL, Isoleucine--tRNA ligase, ... | | Authors: | Chen, B, Luo, S, Zhou, H. | | Deposit date: | 2020-09-25 | | Release date: | 2021-02-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.895 Å) | | Cite: | Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase.
Nat Commun, 12, 2021
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7D59
 | | cryo-EM structure of human RNA polymerase III in apo state | | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | Authors: | Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2020-09-25 | | Release date: | 2021-02-17 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into transcriptional regulation of human RNA polymerase III.
Nat.Struct.Mol.Biol., 28, 2021
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7DHY
 | | Arsenic-bound p53 DNA-binding domain mutant G245S | | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | | Authors: | Chen, S, Lu, M. | | Deposit date: | 2020-11-18 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Cancer Cell, 39, 2021
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7D2S
 | | Crystal structure of Rsu1/PINCH1_LIM5C complex | | Descriptor: | GLYCEROL, LIM and senescent cell antigen-like-containing domain protein 1, Ras suppressor protein 1, ... | | Authors: | Yang, H, Wei, Z, Cong, Y. | | Deposit date: | 2020-09-17 | | Release date: | 2021-02-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.653 Å) | | Cite: | Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Elife, 10, 2021
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7D9K
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7DSA
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7D2U
 | | Crystal structure of Rsu1/PINCH1_LIM45C complex | | Descriptor: | GLYCEROL, LIM and senescent cell antigen-like-containing domain protein 1, MALONATE ION, ... | | Authors: | Yang, H, Wei, Z, Cong, Y. | | Deposit date: | 2020-09-17 | | Release date: | 2021-02-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Elife, 10, 2021
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1W3Z
 | | SeMet derivative of BbCRASP-1 from Borrelia Burgdorferi | | Descriptor: | BBCRASP-1 | | Authors: | Cordes, F.S, Roversi, P, Goodstadt, L, Ponting, C, Kraiczy, P, Skerka, C, Kirschfink, M, Simon, M.M, Brade, V, Zipfel, P, Wallich, R, Lea, S.M. | | Deposit date: | 2004-07-21 | | Release date: | 2005-02-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | A Novel Fold for the Factor H-Binding Protein Bbcrasp-1 of Borrelia Burgdorferi
Nat.Struct.Mol.Biol., 12, 2005
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1W97
 | | cyto-EpsL: the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae | | Descriptor: | TYPE II SECRETION SYSTEM PROTEIN L | | Authors: | Abendroth, J, Bagdasarian, M, Sansdkvist, M, Hol, W.G.J. | | Deposit date: | 2004-10-06 | | Release date: | 2004-11-30 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The Structure of the Cytoplasmic Domain of Epsl, an Inner Membrane Component of the Type II Secretion System of Vibrio Cholerae: An Unusual Member of the Actin-Like ATPase Superfamily
J.Mol.Biol., 344, 2004
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7D9V
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7D8P
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7DS8
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7DSZ
 | | Crystal structure of Amuc_1102 from Akkermansia muciniphila | | Descriptor: | Amuc_1102, CHLORIDE ION | | Authors: | Xiang, R, Wang, J, Wang, Y, Zhang, M, Wang, M. | | Deposit date: | 2021-01-04 | | Release date: | 2021-02-24 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Amuc_1102 fromAkkermansia muciniphilaadopts animmunoglobulin-like fold related to archaeal type IV pilus
Biochem.Biophys.Res.Commun., 547, 2021
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4PPH
 | | Crystal structure of conglutin gamma, a unique basic 7S globulin from lupine seeds | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Czubinski, J, Barciszewski, J, Gilski, M, Lampart-Szczapa, E, Jaskolski, M. | | Deposit date: | 2014-02-27 | | Release date: | 2015-02-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.009 Å) | | Cite: | Structure of gamma-conglutin: insight into the quaternary structure of 7S basic globulins from legumes.
Acta Crystallogr.,Sect.D, 71, 2015
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7DHZ
 | | Arsenic-bound p53 DNA-binding domain mutant R249S | | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | | Authors: | Chen, S, Lu, M. | | Deposit date: | 2020-11-18 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Cancer Cell, 39, 2021
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