6PMJ
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![BU of 6pmj by Molmil](/molmil-images/mine/6pmj) | Sigm28-transcription initiation complex with specific promoter at the state 2 | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Liu, B, Shi, W. | Deposit date: | 2019-07-02 | Release date: | 2020-05-13 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.91 Å) | Cite: | Structural basis of bacterial sigma28-mediated transcription reveals roles of the RNA polymerase zinc-binding domain. Embo J., 39, 2020
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7ANT
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![BU of 7ant by Molmil](/molmil-images/mine/7ant) | Structure of CYP153A from Polaromonas sp. | Descriptor: | 1,2-ETHANEDIOL, Cytochrome P450, HEME C | Authors: | Zukic, E, Rowlinson, B, Sharma, M, Hoffman, S, Hauer, B, Grogan, G. | Deposit date: | 2020-10-12 | Release date: | 2021-04-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Substrate Anchoring and Flexibility Reduction in CYP153AM.aq Leads to Highly Improved Efficiency toward Octanoic Acid Acs Catalysis, 11, 2021
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7ZLR
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![BU of 7zlr by Molmil](/molmil-images/mine/7zlr) | Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 | Descriptor: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | Authors: | Ramachandran, S, Ciulli, A, Makukhin, N. | Deposit date: | 2022-04-15 | Release date: | 2023-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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4X5Q
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![BU of 4x5q by Molmil](/molmil-images/mine/4x5q) | Crystal structure of FimH in complex with 5-nitro-indolinylphenyl alpha-D-mannopyranoside | Descriptor: | 4-(5-nitro-1H-indol-1-yl)phenyl alpha-D-mannopyranoside, Protein FimH | Authors: | Preston, R.C, Jakob, R.P, Fiege, B, Zihlmann, P, Rabbani, S, Schwardt, O, Jiang, X, Ernst, B, Maier, T. | Deposit date: | 2014-12-05 | Release date: | 2015-05-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. Chembiochem, 16, 2015
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6SOF
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![BU of 6sof by Molmil](/molmil-images/mine/6sof) | human insulin receptor ectodomain bound by 4 insulin | Descriptor: | Insulin, Insulin receptor | Authors: | Gutmann, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. | Deposit date: | 2019-08-29 | Release date: | 2019-11-13 | Last modified: | 2020-05-27 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain. J.Cell Biol., 219, 2020
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7AO7
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![BU of 7ao7 by Molmil](/molmil-images/mine/7ao7) | Structure of CYP153A from Polaromonas sp. in complex with octan-1-ol | Descriptor: | Cytochrome P450, OCTAN-1-OL, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Zukic, E, Rowlinson, B, Sharma, M, Hoffmann, S, Hauer, B, Grogan, G. | Deposit date: | 2020-10-13 | Release date: | 2021-04-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Substrate Anchoring and Flexibility Reduction in CYP153AM.aq Leads to Highly Improved Efficiency toward Octanoic Acid Acs Catalysis, 11, 2021
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7TFD
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![BU of 7tfd by Molmil](/molmil-images/mine/7tfd) | P. polymyxa GS(12) - apo | Descriptor: | Glutamine synthetase, MAGNESIUM ION | Authors: | Travis, B.A, Peck, J, Schumacher, M.A. | Deposit date: | 2022-01-06 | Release date: | 2022-06-29 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
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6MAJ
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![BU of 6maj by Molmil](/molmil-images/mine/6maj) | HBO1 is required for the maintenance of leukaemia stem cells | Descriptor: | 4-fluoro-N'-[(3-hydroxyphenyl)sulfonyl]-5-methyl[1,1'-biphenyl]-3-carbohydrazide, BRD1 protein, GLYCEROL, ... | Authors: | Ren, B, Peat, T.S, Monahan, B, Dawson, M, Street, I. | Deposit date: | 2018-08-27 | Release date: | 2019-12-25 | Last modified: | 2020-01-22 | Method: | X-RAY DIFFRACTION (2.139 Å) | Cite: | HBO1 is required for the maintenance of leukaemia stem cells. Nature, 577, 2020
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8PG0
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![BU of 8pg0 by Molmil](/molmil-images/mine/8pg0) | Human OATP1B3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ... | Authors: | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2023-06-17 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun, 14, 2023
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6MDE
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4X6I
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![BU of 4x6i by Molmil](/molmil-images/mine/4x6i) | Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. | Descriptor: | 2-amino-4-bromo-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}benzamide, Cathepsin K, SULFATE ION | Authors: | Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M. | Deposit date: | 2014-12-08 | Release date: | 2015-09-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58, 2015
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8D4Q
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![BU of 8d4q by Molmil](/molmil-images/mine/8d4q) | Crystal Structure of Neutrophil Elastase Inhibited by Eap1 from S. aureus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, Neutrophil elastase | Authors: | Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V. | Deposit date: | 2022-06-02 | Release date: | 2022-12-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023
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6OZZ
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![BU of 6ozz by Molmil](/molmil-images/mine/6ozz) | N terminally deleted GapR crystal structure from C. crescentus | Descriptor: | UPF0335 protein CC_3319 | Authors: | Tarry, M, Harmel, C, Taylor, J.A, Marczynski, G.T, Schmeing, T.M. | Deposit date: | 2019-05-16 | Release date: | 2019-11-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.304 Å) | Cite: | Structures of GapR reveal a central channel which could accommodate B-DNA. Sci Rep, 9, 2019
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7B14
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![BU of 7b14 by Molmil](/molmil-images/mine/7b14) | Nanobody E bound to Spike-RBD in a localized reconstruction | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody against SARS-CoV-2, Spike protein S1 | Authors: | Hallberg, B.M, Das, H. | Deposit date: | 2020-11-23 | Release date: | 2021-04-28 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape Science, 371, 2021
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6MDV
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![BU of 6mdv by Molmil](/molmil-images/mine/6mdv) | Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with high-mannose glycan | Descriptor: | CALCIUM ION, Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Klontz, E.H, Trastoy, B, Orwenyo, J, Wang, L.X, Guerin, M.E, Sundberg, E.J. | Deposit date: | 2018-09-05 | Release date: | 2019-02-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. ACS Cent Sci, 5, 2019
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5F19
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![BU of 5f19 by Molmil](/molmil-images/mine/5f19) | The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lucido, M.J, Orlando, B.J, Malkowski, M.G. | Deposit date: | 2015-11-30 | Release date: | 2016-03-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry, 55, 2016
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5KLU
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![BU of 5klu by Molmil](/molmil-images/mine/5klu) | |
6SIU
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![BU of 6siu by Molmil](/molmil-images/mine/6siu) | Crystal structure of IbpAFic2 covalently tethered to Cdc42 | Descriptor: | Cell division control protein 42 homolog, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Gulen, B, Roselin, M, Albers, M, Hedberg, C, Itzen, A, Pogenberg, V. | Deposit date: | 2019-08-12 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture. Nat.Chem., 12, 2020
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6F5C
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5EVM
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![BU of 5evm by Molmil](/molmil-images/mine/5evm) | Crystal Structure of Nipah Virus Fusion Glycoprotein in the Prefusion State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, MALONATE ION, ... | Authors: | Xu, K, Nikolov, D.B. | Deposit date: | 2015-11-20 | Release date: | 2015-12-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.367 Å) | Cite: | Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. Plos Pathog., 11, 2015
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8Q4H
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![BU of 8q4h by Molmil](/molmil-images/mine/8q4h) | a membrane-bound menaquinol:organohalide oxidoreductase complex RDH complex | Descriptor: | (~{Z})-1,2-bis(chloranyl)ethene, CO-METHYLCOBALAMIN, IRON/SULFUR CLUSTER, ... | Authors: | Dongchun, N, Ekundayo, B, Henning, S, Julien, M, Holliger, C, Cimmino, L. | Deposit date: | 2023-08-07 | Release date: | 2023-10-18 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structure of a membrane-bound menaquinol:organohalide oxidoreductase. Nat Commun, 14, 2023
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6P8N
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4WVO
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![BU of 4wvo by Molmil](/molmil-images/mine/4wvo) | An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1 | Descriptor: | (2S)-2-(4-chlorophenyl)-N-{2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethyl}-2-(prop-2-yn-1-yloxy)ethanamide, Abscisic acid receptor PYR1, MAGNESIUM ION, ... | Authors: | Peterson, F.C, Volkman, B.F, Cutler, S.R. | Deposit date: | 2014-11-06 | Release date: | 2015-02-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.251 Å) | Cite: | Agrochemical control of plant water use using engineered abscisic acid receptors. Nature, 520, 2015
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6P96
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![BU of 6p96 by Molmil](/molmil-images/mine/6p96) | OXA-48 carbapanemase, apo form | Descriptor: | Beta-lactamase, CADMIUM ION, CALCIUM ION, ... | Authors: | Smith, C.A, Vakulenko, S.B. | Deposit date: | 2019-06-10 | Release date: | 2019-08-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
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6YIH
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![BU of 6yih by Molmil](/molmil-images/mine/6yih) | Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 2.6 A. | Descriptor: | Baculoviral IAP repeat-containing protein 5, Borealin, Histone H3.1, ... | Authors: | Serena, M, Elliott, P.R, Barr, F.A. | Deposit date: | 2020-04-01 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle. J.Cell Biol., 219, 2020
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