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6YZJ	Closo-carborane ethyl-sulfonamide in complex with CA IX mimic Descriptor: Carbonic anhydrase 2, Carborane ethyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZO	Carborane closo-hexyl-sulfonamide in complex with CA IX mimic Descriptor: Carbonic anhydrase 2, Carborane closo-hexyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZW	Carborane closo-hexyl-sulfonamide in complex with CA II Descriptor: Carbonic anhydrase 2, Carborane closo-hexyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.03 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZU	Carborane nido-pentyl-sulfonamide in complex with CA II Descriptor: Carbonic anhydrase 2, Carborane nido-pentyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZM	Carborane nido-pentyl-sulfonamide in complex with CA IX mimic Descriptor: Carbonic anhydrase 2, Carborane nido-pentyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZQ	Carborane closo-butyl-sulfonamide in complex with CA II Descriptor: Carbonic anhydrase 2, Carborane closo-butyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.04 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZX	Carborane nido-hexyl-sulfonamide in complex with CA II Descriptor: Carbonic anhydrase 2, Carborane nido-hexyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.1 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZN	Closo-carborane butyl-sulfonamide in complex with CA IX mimic Descriptor: Carbonic anhydrase 2, Carborane closo-butyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (0.95 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZT	Closo-carborane propyl-sulfonamide in complex with CA II Descriptor: Carbonic anhydrase 2, Carborane propyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6Z04	Nido-carborane butyl-sulfonamide in complex with CA IX mimic Descriptor: Carbonic anhydrase 2, Carborane nido-butyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZL	Closo-carborane methyl-sulfonamide in complex with CA IX mimic Descriptor: Carbonic anhydrase 2, Carborane methyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZP	Carborane nido-hexyl-sulfonamide in complex with CA IX mimic Descriptor: Carbonic anhydrase 2, Carborane nido-hexyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.35 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZV	Closo-carborane ethyl-sulfonamide in complex with CA II Descriptor: Carbonic anhydrase 2, Carborane ethyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.65 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZS	Carborane closo-pentyl-sulfonamide in complex with CA II Descriptor: Carbonic anhydrase 2, Carborane closo-pentyl-sulfonamide, SODIUM ION, ... Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZK	Carborane closo-pentyl-sulfonamide in complex with CA IX mimic Descriptor: Carbonic anhydrase 2, Carborane closo-pentyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (0.99 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6YZR	Carborane nido-butyl-sulfonamide in complex with CA II Descriptor: Carbonic anhydrase 2, Carborane nido-butyl-sulfonamide, ZINC ION Authors: Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. Deposit date: 2020-05-07 Release date: 2020-10-28 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
6QNG	Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide Descriptor: Carbonic anhydrase 12, ZINC ION, ~{N}-butyl-4-chloranyl-2-(cyclohexylamino)-5-sulfamoyl-benzamide Authors: Dvinskis, E, Leitans, J, Tars, K. Deposit date: 2019-02-11 Release date: 2020-03-04 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide To Be Published
6LAI	The structural basis of the beta-carbonic anhydrase CafD (E54A mutant) of the filamentous fungus Aspergillus fumigatus Descriptor: Carbonic anhydrase, ZINC ION Authors: Jin, M.S, Kim, S, Kim, N.J, Hong, S, Kim, S, Sung, J. Deposit date: 2019-11-12 Release date: 2019-11-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The structural analysis of non-catalytic zinc binding site in the minor beta-carbonic anhydrase CafD To be published
3M2X	Carbonic Anhydrase II in complex with novel sulfonamide inhibitor Descriptor: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, N-[(R)-[(3,4-dimethoxyphenyl)amino](phenoxy)methyl]sulfamide, ... Authors: Schulze Wischeler, J, Heine, A, Klebe, G. Deposit date: 2010-03-08 Release date: 2011-05-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Structural investigation and inhibitor studies on Carbonic Anhydrase II To be Published
1HCA	UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-04-02 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II. J.Am.Chem.Soc., 113, 1991
1V9I	Crystal Structure Analysis of the site specific mutant (Q253C) of bovine carbonic anhydrase II Descriptor: Carbonic anhydrase II, ZINC ION Authors: Saito, R, Sato, T, Ikai, A, Tanaka, N. Deposit date: 2004-01-26 Release date: 2004-02-10 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Crystal Structure Analysis of the site specific mutant (Q253C) of bovine carbonic anhydrase II To be Published
1LG6	Crystal Structure Analysis of HCA II Mutant T199P in Complex with Thiocyanate Descriptor: Carbonic anhydrase II, THIOCYANATE ION, ZINC ION Authors: Huang, S, Sjoblom, B, Sauer-Eriksson, A.E, Jonsson, B.-H. Deposit date: 2002-04-15 Release date: 2002-07-24 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant. Biochemistry, 41, 2002
3V3F	Kinetic and structural studies of thermostabilized mutants of HCA II. Descriptor: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION Authors: Boone, C.D, Fisher, S.Z, McKenna, R. Deposit date: 2011-12-13 Release date: 2012-06-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V3I	Kinetic and structural studies of thermostabilized mutants of HCA II. Descriptor: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION Authors: Boone, C.D, Fisher, S.Z, McKenna, R. Deposit date: 2011-12-13 Release date: 2012-06-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V3G	Kinetic and structural studies of thermostabilized mutants of HCA II. Descriptor: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION Authors: Boone, C.D, Fisher, S.Z, McKenna, R. Deposit date: 2011-12-13 Release date: 2012-06-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.5581 Å) Cite: Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012

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