6YZN
Closo-carborane butyl-sulfonamide in complex with CA IX mimic
Summary for 6YZN
| Entry DOI | 10.2210/pdb6yzn/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, Carborane closo-butyl-sulfonamide, ... (4 entities in total) |
| Functional Keywords | carbonic anhydrase, ca inhibitor, lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29534.62 |
| Authors | Kugler, M.,Brynda, J.,Pospisilova, K.,Rezacova, P. (deposition date: 2020-05-07, release date: 2020-10-28, Last modification date: 2024-01-24) |
| Primary citation | Kugler, M.,Holub, J.,Brynda, J.,Pospisilova, K.,Anwar, S.E.,Bavol, D.,Havranek, M.,Kral, V.,Fabry, M.,Gruner, B.,Rezacova, P. The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35:1800-1810, 2020 Cited by PubMed: 32962427DOI: 10.1080/14756366.2020.1816996 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (0.95 Å) |
Structure validation
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