6H0U
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![BU of 6h0u by Molmil](/molmil-images/mine/6h0u) | Glycogen synthase kinase-3 beta (GSK3) complex with a covalent [1,2,4]triazolo[1,5-a][1,3,5]triazine inhibitor | Descriptor: | (2~{R})-3-[7-azanyl-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl]-2-cyano-propanamide, CHLORIDE ION, GLYCEROL, ... | Authors: | Marcovich, I, Demitri, N, De Zorzi, R, Storici, P. | Deposit date: | 2018-07-10 | Release date: | 2019-05-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Triazolotriazine-Based Dual GSK-3 beta /CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. Chemmedchem, 14, 2019
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1P7L
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![BU of 1p7l by Molmil](/molmil-images/mine/1p7l) | S-Adenosylmethionine synthetase complexed with AMPPNP and Met. | Descriptor: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, METHIONINE, ... | Authors: | Takusagawa, F, Komoto, J. | Deposit date: | 2003-05-02 | Release date: | 2004-03-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the s-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET. Biochemistry, 43, 2004
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1FGS
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![BU of 1fgs by Molmil](/molmil-images/mine/1fgs) | FOLYLPOLYGLUTAMATE SYNTHETASE FROM LACTOBACILLUS CASEI | Descriptor: | FOLYLPOLYGLUTAMATE SYNTHETASE, MAGNESIUM ION, PYROPHOSPHATE 2- | Authors: | Sun, X, Bognar, A, Baker, E, Smith, C. | Deposit date: | 1998-04-29 | Release date: | 1999-05-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase. Proc.Natl.Acad.Sci.USA, 95, 1998
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1QRU
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1J20
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1QRS
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1QRT
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6MGG
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![BU of 6mgg by Molmil](/molmil-images/mine/6mgg) | Succinyl-CoA synthase from Francisella tularensis, phosphorylated, in complex with CoA | Descriptor: | 1,2-ETHANEDIOL, COENZYME A, MAGNESIUM ION, ... | Authors: | Osipiuk, J, Maltseva, N, Jedrzejczak, R, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-09-13 | Release date: | 2018-09-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Succinyl-CoA synthase from Francisella tularensis to be published
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1MB9
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![BU of 1mb9 by Molmil](/molmil-images/mine/1mb9) | BETA-LACTAM SYNTHETASE COMPLEXED WITH ATP | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, BETA-LACTAM SYNTHETASE, ... | Authors: | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | Deposit date: | 2002-08-02 | Release date: | 2002-10-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots Proc.Natl.Acad.Sci.USA, 99, 2002
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1KH3
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![BU of 1kh3 by Molmil](/molmil-images/mine/1kh3) | Crystal Structure of Thermus thermophilus HB8 Argininosuccinate Synthetase in complex with inhibitor | Descriptor: | ARGININE, ASPARTIC ACID, Argininosuccinate Synthetase, ... | Authors: | goto, m, Hirotsu, k, miyahara, i, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2001-11-29 | Release date: | 2003-04-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structures of Argininosuccinate Synthetase in Enzyme-ATP Substrates and Enzyme-AMP Product Forms: STEREOCHEMISTRY OF THE CATALYTIC REACTION J.Biol.Chem., 278, 2003
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1RG9
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![BU of 1rg9 by Molmil](/molmil-images/mine/1rg9) | S-Adenosylmethionine synthetase complexed with SAM and PPNP | Descriptor: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Komoto, J, Yamada, T, Takata, Y, Markham, G.D, Takusagawa, F. | Deposit date: | 2003-11-11 | Release date: | 2004-03-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET. Biochemistry, 43, 2004
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6MEL
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![BU of 6mel by Molmil](/molmil-images/mine/6mel) | Succinyl-CoA synthase from Campylobacter jejuni | Descriptor: | CHLORIDE ION, CITRIC ACID, Succinate--CoA ligase [ADP-forming] subunit beta, ... | Authors: | Osipiuk, J, Maltseva, N, Jedrzejczak, R, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-09-06 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Succinyl-CoA synthase from Campylobacter jejuni to be published
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6FM1
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![BU of 6fm1 by Molmil](/molmil-images/mine/6fm1) | Deoxyguanylosuccinate synthase (DgsS) quaternary structure with ATPanddGMP at 2.3 Angstrom resolution | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Adenylosuccinate synthetase, ... | Authors: | Sleiman, D, Loc'h, J, Haouz, A, Kaminski, P.A. | Deposit date: | 2018-01-29 | Release date: | 2019-06-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes. Science, 372, 2021
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4YDU
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![BU of 4ydu by Molmil](/molmil-images/mine/4ydu) | Crystal structure of E. coli YgjD-YeaZ heterodimer in complex with ADP | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, FE (III) ION, ... | Authors: | Zhang, W, Collinet, B, Perrochia, L, Durand, D, Van Tilbeurgh, H. | Deposit date: | 2015-02-23 | Release date: | 2015-03-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli. Nucleic Acids Res., 43, 2015
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1GNG
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![BU of 1gng by Molmil](/molmil-images/mine/1gng) | Glycogen synthase kinase-3 beta (GSK3) complex with FRATtide peptide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FRATTIDE, GLYCOGEN SYNTHASE KINASE-3 BETA, ... | Authors: | Bax, B, Carter, P.S, Lewis, C, Guy, A.R, Bridges, A, Tanner, R, Pettman, G, Mannix, C, Culbert, A.A, Brown, M.J.B, Smith, D.G, Reith, A.D. | Deposit date: | 2001-10-04 | Release date: | 2002-10-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation Structure, 9, 2001
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1BXR
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![BU of 1bxr by Molmil](/molmil-images/mine/1bxr) | STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP | Descriptor: | CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ... | Authors: | Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M. | Deposit date: | 1998-10-08 | Release date: | 1999-04-20 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding. Biochemistry, 38, 1999
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5BS5
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![BU of 5bs5 by Molmil](/molmil-images/mine/5bs5) | EPSP synthase from Acinetobacter baumannii | Descriptor: | 3-phosphoshikimate 1-carboxyvinyltransferase | Authors: | Sutton, K.A, Schultz, L.W, Russo, T.A, Breen, J, Umland, T.C. | Deposit date: | 2015-06-01 | Release date: | 2016-02-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | EPSP synthase from Acinetobacter baumannii Acta Crystallogr.,Sect.F, 2016
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1I09
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6YBU
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![BU of 6ybu by Molmil](/molmil-images/mine/6ybu) | Crystal structure of a native BcsE (349-523) RQ complex with c-di-GMP and ATP bound | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-5'-TRIPHOSPHATE, Bacterial cellulose secretion regulator BcsE, ... | Authors: | Abidi, W, Zouhir, S, Roche, S, Krasteva, P.V. | Deposit date: | 2020-03-17 | Release date: | 2021-02-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Architecture and regulation of an enterobacterial cellulose secretion system. Sci Adv, 7, 2021
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6TCU
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![BU of 6tcu by Molmil](/molmil-images/mine/6tcu) | Glycogen synthase kinase-3 beta (GSK3b) in complex with ligand 1 | Descriptor: | 5-[2,3-bis(fluoranyl)phenyl]-~{N}-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-1~{H}-indazole-3-carboxamide, ACETATE ION, Glycogen synthase kinase-3 beta | Authors: | Lammens, A, Krapp, S, Buonfiglio, R, Ombrato, R. | Deposit date: | 2019-11-06 | Release date: | 2020-09-16 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue andIn VivoActivity in a Mood Disorder Model. Acs Med.Chem.Lett., 11, 2020
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1BYI
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![BU of 1byi by Molmil](/molmil-images/mine/1byi) | STRUCTURE OF APO-DETHIOBIOTIN SYNTHASE AT 0.97 ANGSTROMS RESOLUTION | Descriptor: | DETHIOBIOTIN SYNTHASE | Authors: | Sandalova, T, Schneider, G, Kaeck, H, Lindqvist, Y. | Deposit date: | 1998-10-15 | Release date: | 1999-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Structure of dethiobiotin synthetase at 0.97 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
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6HXP
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6YBB
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![BU of 6ybb by Molmil](/molmil-images/mine/6ybb) | Crystal structure of a native BcsE (217-523) - BcsR-BcsQ (R156E mutant) complex with c-di-GMP and ATP bound | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-5'-TRIPHOSPHATE, Bacterial cellulose secretion regulator BcsE, ... | Authors: | Abidi, W, Zouhir, S, Roche, S, Krasteva, P.V. | Deposit date: | 2020-03-16 | Release date: | 2021-02-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Architecture and regulation of an enterobacterial cellulose secretion system. Sci Adv, 7, 2021
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4EJN
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![BU of 4ejn by Molmil](/molmil-images/mine/4ejn) | Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide | Descriptor: | 1,2-ETHANEDIOL, 2-BUTANOL, N-(4-{5-[3-(acetylamino)phenyl]-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl}benzyl)-3-fluorobenzamide, ... | Authors: | Eathiraj, S. | Deposit date: | 2012-04-06 | Release date: | 2012-05-23 | Last modified: | 2013-01-02 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. J.Med.Chem., 55, 2012
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7F5U
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