4ADT
 
 | | Crystal structure of plasmodial PLP synthase | | Descriptor: | PHOSPHATE ION, PYRIDOXINE BIOSYNTHETIC ENZYME PDX1 HOMOLOGUE, PUTATIVE | | Authors: | Guedez, G, Sinning, I, Tews, I. | | Deposit date: | 2012-01-03 | | Release date: | 2012-01-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Assembly of the Eukaryotic Plp-Synthase Complex from Plasmodium and Activation of the Pdx1 Enzyme.
Structure, 20, 2012
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4DBS
 | | Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid | | Descriptor: | 3-[(4-nitronaphthalen-1-yl)amino]benzoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Chen, M, Christianson, D.W, Winkler, J.D, Penning, T.M. | | Deposit date: | 2012-01-16 | | Release date: | 2012-03-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.852 Å) | | Cite: | Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Bioorg.Med.Chem.Lett., 22, 2012
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3LJF
 | | The X-ray structure of iron superoxide dismutase from Pseudoalteromonas haloplanktis (crystal form II) | | Descriptor: | FE (III) ION, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, iron superoxide dismutase | | Authors: | Merlino, A, Russo Krauss, I, Rossi, B, Conte, M, Vergara, A, Sica, F. | | Deposit date: | 2010-01-26 | | Release date: | 2010-09-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure and flexibility in cold-adapted iron superoxide dismutases: the case of the enzyme isolated from Pseudoalteromonas haloplanktis.
J.Struct.Biol., 172, 2010
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4ADU
 | | Crystal structure of plasmodial PLP synthase with bound R5P intermediate | | Descriptor: | 1,2-ETHANEDIOL, PYRIDOXINE BIOSYNTHETIC ENZYME PDX1 HOMOLOGUE, PUTATIVE, ... | | Authors: | Guedez, G, Sinning, I, Tews, I. | | Deposit date: | 2012-01-03 | | Release date: | 2012-01-25 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Assembly of the Eukaryotic Plp-Synthase Complex from Plasmodium and Activation of the Pdx1 Enzyme.
Structure, 20, 2012
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4YJP
 | | THE KINASE DOMAIN OF HUMAN SPLEEN TYROSINE (SYK) IN COMPLEX WITH GTC000223 | | Descriptor: | 2-[{2-[(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)amino]pyrimidin-4-yl}(1H-indazol-4-yl)amino]ethanol, DIMETHYL SULFOXIDE, Tyrosine-protein kinase SYK | | Authors: | Somers, D.O, Neu, M. | | Deposit date: | 2015-03-03 | | Release date: | 2015-09-30 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg. Med. Chem. Lett., 21, 2011
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4YJU
 | | THE KINASE DOMAIN OF HUMAN SPLEEN TYROSINE (SYK) IN COMPLEX WITH GTC000249 | | Descriptor: | N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-5-fluoro-N~4~-(1H-indazol-4-yl)-N~4~-methylpyrimidine-2,4-diamine, Tyrosine-protein kinase SYK | | Authors: | Somers, D.O, Neu, M, Stuckey, J. | | Deposit date: | 2015-03-03 | | Release date: | 2015-09-30 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg. Med. Chem. Lett., 21, 2011
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1CRI
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2XUS
 | | Crystal Structure of the BRMS1 N-terminal region | | Descriptor: | BREAST CANCER METASTASIS-SUPPRESSOR 1, CHLORIDE ION, SULFATE ION | | Authors: | Spinola-Amilibia, M, Rivera, J, Ortiz-Lombardia, M, Romero, A, Neira, J.L, Bravo, J. | | Deposit date: | 2010-10-20 | | Release date: | 2011-07-27 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.912 Å) | | Cite: | The Structure of Brms1 Nuclear Export Signal and Snx6 Interacting Region Reveals a Hexamer Formed by Antiparallel Coiled Coils.
J.Mol.Biol., 411, 2011
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6Y9L
 | | Crystal structure of TSWV glycoprotein N ectodomain (sGn) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein, ... | | Authors: | Dessau, M, Bahat, Y. | | Deposit date: | 2020-03-09 | | Release date: | 2020-09-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Crystal structure of tomato spotted wilt virus G N reveals a dimer complex formation and evolutionary link to animal-infecting viruses
Proc.Natl.Acad.Sci.USA, 117, 2020
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8OE6
 | | Structure of hyperstable haloalkane dehalogenase variant DhaA231 | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Structure of hyperstable haloalkane dehalogenase variant DhaA231 | | Authors: | Marek, M. | | Deposit date: | 2023-03-10 | | Release date: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning.
Acs Catalysis, 13, 2023
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3GHN
 | | Crystal structure of the exosite-containing fragment of human ADAMTS13 (form-2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, A disintegrin and metalloproteinase with thrombospondin motifs 13, ... | | Authors: | Akiyama, M, Takeda, S, Kokame, K, Takagi, J, Miyata, T. | | Deposit date: | 2009-03-04 | | Release date: | 2009-10-27 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor
To be Published
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8EE7
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8EE4
 | | Structure of PtuA | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, PtuA | | Authors: | Shen, Z.F, Fu, T.M. | | Deposit date: | 2022-09-06 | | Release date: | 2024-01-03 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense.
Nat.Struct.Mol.Biol., 31, 2024
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8EEA
 | | Structure of E.coli Septu (PtuAB) complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, PtuA, PtuB | | Authors: | Shen, Z.F, Fu, T.M. | | Deposit date: | 2022-09-06 | | Release date: | 2023-12-27 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense.
Nat.Struct.Mol.Biol., 31, 2024
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4YPO
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8OE2
 | | Structure of hyperstable haloalkane dehalogenase variant DhaA223 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... | | Authors: | Marek, M. | | Deposit date: | 2023-03-10 | | Release date: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning.
Acs Catalysis, 13, 2023
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4X64
 | | Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Demirci, H, Chen, J, Choi, J, Soltis, M, Puglisi, J.D. | | Deposit date: | 2014-12-06 | | Release date: | 2015-11-18 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics.
Nat.Struct.Mol.Biol., 23, 2016
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8DHZ
 | | NMR Structure of Ac-hGal(17-30)NH2, an N-terminally acetylated fragment of the C-terminus of human galanin | | Descriptor: | Galanin | | Authors: | Kraichely, K.N, Hendy, C.M, Parnham, S, Giuliano, M.W. | | Deposit date: | 2022-06-28 | | Release date: | 2022-08-24 | | Last modified: | 2024-10-23 | | Method: | SOLUTION NMR | | Cite: | The neuropeptide galanin adopts an irregular secondary structure.
Biochem.Biophys.Res.Commun., 626, 2022
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8DJ4
 | | NMR Solution Structure of C-terminally amidated, Full-length Human Galanin | | Descriptor: | Galanin | | Authors: | Wilkinson, R.E, Kraichely, K.N, Buchanan, L.E, Parnham, S, Giuliano, M.W. | | Deposit date: | 2022-06-30 | | Release date: | 2022-08-24 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | The neuropeptide galanin adopts an irregular secondary structure.
Biochem.Biophys.Res.Commun., 626, 2022
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1GWT
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4X66
 | | Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Demirci, H, Chen, J, Choi, J, Soltis, M, Puglisi, J.D. | | Deposit date: | 2014-12-06 | | Release date: | 2015-11-18 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (3.446 Å) | | Cite: | N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics.
Nat.Struct.Mol.Biol., 23, 2016
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4YJT
 | | THE KINASE DOMAIN OF HUMAN SPLEEN TYROSINE (SYK) IN COMPLEX WITH GTC000233 | | Descriptor: | GLYCEROL, N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-N~4~-ethyl-5-fluoro-N~4~-(1H-indazol-4-yl)pyrimidine-2,4-diamine, Tyrosine-protein kinase SYK | | Authors: | Somers, D.O, Neu, M, Stuckey, J. | | Deposit date: | 2015-03-03 | | Release date: | 2015-09-30 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg. Med. Chem. Lett., 21, 2011
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3GHM
 | | Crystal structure of the exosite-containing fragment of human ADAMTS13 (form-1) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, A disintegrin and metalloproteinase with thrombospondin motifs 13, ... | | Authors: | Akiyama, M, Takeda, S, Kokame, K, Takagi, J, Miyata, T. | | Deposit date: | 2009-03-04 | | Release date: | 2009-10-27 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor
To be Published
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4YH2
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2W8S
 | | CRYSTAL STRUCTURE OF A catalytically promiscuous PHOSPHONATE MONOESTER HYDROLASE FROM Burkholderia caryophylli | | Descriptor: | FE (III) ION, GLYCEROL, PHOSPHONATE MONOESTER HYDROLASE, ... | | Authors: | Jonas, S, van Loo, B, Hyvonen, M, Hollfelder, F. | | Deposit date: | 2009-01-19 | | Release date: | 2010-02-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | An Efficient, Multiply Promiscuous Hydrolase in the Alkaline Phosphatase Superfamily.
Proc.Natl.Acad.Sci.USA, 107, 2010
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