PDB: 13258 resultsInfo pagesStatus searchChemie searchBIRD

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7AAC	Crystal structure of the catalytic domain of human PARP1 in complex with veliparib Descriptor: (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, Poly [ADP-ribose] polymerase 1, SULFATE ION Authors: Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D. Deposit date: 2020-09-04 Release date: 2021-01-13 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.593 Å) Cite: Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res., 49, 2021
7AAB	Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor EB-47 Descriptor: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION Authors: Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D. Deposit date: 2020-09-04 Release date: 2021-01-13 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res., 49, 2021
8G0H	Human PARP1 deltaV687-E688 bound to UKTT5 (compound 10) and to a DNA double strand break. Descriptor: 2-(4-{[2-(1H-benzimidazol-2-yl)ethyl]carbamoyl}phenyl)-1H-benzimidazole-7-carboxamide, DNA (5'-D(*CP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*CP*G)-3'), ... Authors: Rouleau-Turcotte, E, Pascal, J.M. Deposit date: 2023-01-31 Release date: 2024-02-07 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem.J., 481, 2024
2ILK	CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-10 AT 1.6 ANGSTROMS RESOLUTION Descriptor: INTERLEUKIN-10, SULFATE ION Authors: Zdanov, A, Schalk-Hihi, C, Wlodawer, A. Deposit date: 1996-07-01 Release date: 1996-10-14 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor. Protein Sci., 5, 1996
7U1A	RFC:PCNA bound to dsDNA with a ssDNA gap of six nucleotides Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA - Primer, DNA - Template, ... Authors: Liu, X, Gaubitz, C, Pajak, J, Kelch, B.A. Deposit date: 2022-02-20 Release date: 2022-07-06 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA. Elife, 11, 2022
7U1P	RFC:PCNA bound to DNA with a ssDNA gap of five nucleotides Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA - Primer, DNA - Template, ... Authors: Liu, X, Gaubitz, C, Pajak, J, Kelch, B.A. Deposit date: 2022-02-21 Release date: 2022-07-06 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3 Å) Cite: A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA. Elife, 11, 2022
2HDZ	Crystal Structure Analysis of the UBF HMG box5 Descriptor: Nucleolar transcription factor 1 Authors: Rong, H, Teng, M.K, Niu, L.W. Deposit date: 2006-06-21 Release date: 2007-06-26 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1 Acta Crystallogr.,Sect.D, 63, 2007
1PFL	REFINED SOLUTION STRUCTURE OF HUMAN PROFILIN I Descriptor: PROFILIN I Authors: Metzler, W.J, Farmer II, B.T, Constantine, K.L, Friedrichs, M.S, Lavoie, T, Mueller, L. Deposit date: 1994-12-12 Release date: 1995-03-31 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Refined solution structure of human profilin I. Protein Sci., 4, 1995
7G84	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1102357527 Descriptor: DIMETHYL SULFOXIDE, FORMIC ACID, N-[(3R)-6-oxopiperidin-3-yl]-1,3-thiazole-4-carboxamide, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.811 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G86	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1137725943 Descriptor: DIMETHYL SULFOXIDE, FORMIC ACID, N-[(1H-indol-4-yl)methyl]ethanamine, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.699 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8H	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1198180782 Descriptor: 5-methoxy-1H-pyrrolo[3,2-b]pyridine, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.67 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8I	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1198316457 Descriptor: 4,4-difluorocyclohexane-1-carboxamide, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.468 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G80	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1041785508 Descriptor: 5-(1,3-thiazol-2-yl)-1H-1,2,4-triazole, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.671 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8K	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1217131798 Descriptor: (3M)-3-(2-methyl-1H-imidazol-1-yl)pyridine, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.491 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G90	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1509195674 Descriptor: 4-[(3S)-piperidin-3-yl]-1H-indole, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.911 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G88	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1148747945 Descriptor: DIMETHYL SULFOXIDE, FORMIC ACID, N-(3-methylpyridin-4-yl)acetamide, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.869 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G93	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1565771450 Descriptor: DIMETHYL SULFOXIDE, FORMIC ACID, N-(8-methyl-1,2,3,4-tetrahydroquinolin-5-yl)acetamide, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.693 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8B	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z100643660 Descriptor: DIMETHYL SULFOXIDE, FORMIC ACID, N,1-dimethyl-1H-indole-3-carboxamide, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.42 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G81	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z104474512 Descriptor: 1-(2-ethoxyphenyl)piperazine, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.51 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8E	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z104479710 Descriptor: 1-(1H-benzimidazol-2-yl)methanamine, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.79 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G89	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1192341021 Descriptor: 1-(5-amino-2H-isoindol-2-yl)ethan-1-one, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.901 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8P	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1269184613 Descriptor: 1,3-benzothiazole-6-sulfonamide, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.209 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8C	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1037511924 Descriptor: 1-(difluoromethyl)-1H-indol-5-amine, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.176 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8S	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z1270393711 Descriptor: 5-(methoxymethyl)-1,2-oxazole-3-carboxamide, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.6 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published
7G8D	ARHGEF2 PanDDA analysis group deposition -- ARHGEF2 and RhoA in complex with Z104474228 Descriptor: 3-methylthiophene-2-carboxylic acid, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Bradshaw, W.J, Katis, V.L, Bountra, C, von Delft, F, Brennan, P.E. Deposit date: 2023-06-22 Release date: 2023-07-12 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.937 Å) Cite: ARHGEF2 PanDDA analysis group deposition To Be Published

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