PDB: 27348 resultsInfo pagesStatus searchChemie searchBIRD

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5X54	Crystal structure of the Keap1 Kelch domain in complex with a tetrapeptide Descriptor: ACE-GLU-TRP-TRP-TRP, ACETATE ION, Kelch-like ECH-associated protein 1 Authors: Sogabe, S, Kadotani, A, Lane, W, Snell, G. Deposit date: 2017-02-14 Release date: 2017-03-29 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization Biochem. Biophys. Res. Commun., 486, 2017
5IZA	Protein-protein interaction Descriptor: ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein Authors: Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. Deposit date: 2016-03-25 Release date: 2017-07-05 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
5VLK	Short PCSK9 delta-P' complex with shrunken peptide bearing homo-Arginine Descriptor: ACE-THR-VAL-PHE-THR-SER-TRP-GLU-GLU-TYR-LEU-ASP-TRP-VAL-NH2 peptide, ACE-TRP-ASN-LEU-VAL-HRG-ILE-GLY-LEU-LEU peptide, CALCIUM ION, ... Authors: Eigenbrot, C, Ultsch, M. Deposit date: 2017-04-25 Release date: 2017-08-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24, 2017
5VLH	Short PCSK9 delta-P' complex with peptide Pep1 Descriptor: ACE-THR-VAL-PHE-THR-SER-TRP-GLU-GLU-TYR-LEU-ASP-TRP-VAL-NH2, CALCIUM ION, CYS-ARG-LEU-PRO-TRP-ASN-LEU-GLN-ARG-ILE-GLY-LEU-PRO-CYS, ... Authors: Eigenbrot, C, Ultsch, M. Deposit date: 2017-04-25 Release date: 2017-08-16 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24, 2017
5VLL	Short PCSK9 delta-P' complex with peptide Pep3 Descriptor: ACE-THR-VAL-PHE-THR-SER-TRP-GLU-GLU-TYR-LEU-ASP-TRP-VAL-NH2, CALCIUM ION, CYS-PHE-ILE-PRO-TRP-ASN-LEU-GLN-ARG-ILE-GLY-LEU-LEU-CYS, ... Authors: Eigenbrot, C, Ultsch, M. Deposit date: 2017-04-25 Release date: 2017-08-16 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.37 Å) Cite: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24, 2017
8FYM	Crystal structure of Fab235 in complex with MPER peptide Descriptor: ALA-SER-LEU-TRP-ASN-TRP-PHE-ASN-ILE-THR-ASN-TRP-LEU-TRP-TYR-ILE-LYS-LYS-LYS, CHLORIDE ION, Fab235, ... Authors: Tan, K, Kim, M, Reinherz, E.L. Deposit date: 2023-01-26 Release date: 2023-10-11 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility. Nat Commun, 14, 2023
1U85	ARG326-TRP mutant of the third zinc finger of BKLF Descriptor: Kruppel-like factor 3, ZINC ION Authors: Cram, E.D, Mackay, J.P, Matthews, J.M. Deposit date: 2004-08-05 Release date: 2005-08-23 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structures of tryptophan-containing CCHH zinc finger mutants To be Published
5O4Y	Structure of human PD-L1 in complex with inhibitor Descriptor: PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2, Programmed cell death 1 ligand 1 Authors: Magiera, K, Grudnik, P, Dubin, G, Holak, T.A. Deposit date: 2017-05-31 Release date: 2017-09-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint. Angew. Chem. Int. Ed. Engl., 56, 2017
5ZPW	Generation of a long-acting fusion inhibitor against HIV-1 Descriptor: MET-THR-TRP-GLU-GLU-TRP-ASP-MK8-LYS-ILE-GLU-MK8-TYR-THR-MK8-LYS-ILE-GLU-MK8-LEU-ILE-LYS-LYS-SER, Transmembrane protein gp41 Authors: Guo, Y, Shi, X.L. Deposit date: 2018-04-16 Release date: 2019-03-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.199 Å) Cite: Generation of a long-acting fusion inhibitor against HIV-1. Medchemcomm, 9, 2018
6R00	OphA DeltaC6 V404F complex with SAH Descriptor: PHE-PRO-TRP-MVA-ILE-MVA-PHE-GLY-VAL-ILE-GLY-VAL-ILE-GLY, Peptide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE Authors: Song, H, Naismith, J.H. Deposit date: 2019-03-12 Release date: 2020-04-01 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Substrate Plasticity of a Fungal Peptide alpha-N-Methyltransferase. Acs Chem.Biol., 15, 2020
6QZY	full length OphA V406P in complex with SAH Descriptor: ASN-GLY-PHE-PRO-TRP-MVA-ILE-MVA-VAL-GLY-PRO-ILE-GLY, MAGNESIUM ION, Peptide N-methyltransferase, ... Authors: Song, H, Naismith, J.H. Deposit date: 2019-03-12 Release date: 2020-04-01 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Substrate Plasticity of a Fungal Peptide alpha-N-Methyltransferase. Acs Chem.Biol., 15, 2020
6NSV	Crystal structure of the human CHIP TPR domain in complex with a 5mer acetylated optimized peptide Descriptor: ACE-LEU-TRP-TRP-PRO-ASP, CHLORIDE ION, E3 ubiquitin-protein ligase CHIP, ... Authors: Basu, K, Ravalin, M, Bohn, M.-F, Craik, C.S, Gestwicki, J.E. Deposit date: 2019-01-25 Release date: 2019-07-31 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.305 Å) Cite: Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol., 15, 2019
5N89	CRYSTAL STRUCTURE OF STREPTAVIDIN WITH PEPTIDE GNSFDDWLASKG Descriptor: GLY-ASN-SER-PHE-ASP-ASP-TRP-LEU-ALA-SER-LYS-GLY-NH2, GLYCEROL, Streptavidin Authors: Lyamichev, V, Goodrich, L, Sullivan, E, Bannen, R, Benz, J, Albert, T, Patel, J. Deposit date: 2017-02-23 Release date: 2017-10-04 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target. Sci Rep, 7, 2017
5N8E	CRYSTAL STRUCTURE OF STREPTAVIDIN WITH PEPTIDE RDPAPAWAHGGG Descriptor: ARG-ASP-PRO-ALA-PRO-ALA-TRP-ALA-HIS-GLY-GLY-GLY-NH2, SODIUM ION, Streptavidin Authors: Lyamichev, V, Goodrich, L, Sullivan, E, Bannen, R, Benz, J, Albert, T, Patel, J. Deposit date: 2017-02-23 Release date: 2017-10-11 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target. Sci Rep, 7, 2017
5N7X	CRYSTAL STRUCTURE OF STREPTAVIDIN WITH PEPTIDE EWVHPQFEQKAK Descriptor: GLU-TRP-VAL-HIS-PRO-GLN-PHE-GLU-GLN-LYS-ALA-LYS Peptide, Streptavidin Authors: Lyamichev, V, Goodrich, L, Sullivan, E, Bannen, R, Benz, J, Albert, T, Patel, J. Deposit date: 2017-02-21 Release date: 2017-10-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.12 Å) Cite: Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target. Sci Rep, 7, 2017
8TTI	Trp-6-Halogenase BorH complexed with FAD and Trp Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, TRYPTOPHAN, ... Authors: Lingkon, K, Bellizzi, J.J. Deposit date: 2023-08-14 Release date: 2023-08-30 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Crystallographic and thermodynamic evidence of negative cooperativity of flavin and tryptophan binding in the flavin-dependent halogenases AbeH and BorH. Biorxiv, 2023
5N99	CRYSTAL STRUCTURE OF STREPTAVIDIN with cyclic peptide NQpWQ Descriptor: ASN-GLN-DPR-TRP-GLN, Streptavidin Authors: Lyamichev, V, Goodrich, L, Sullivan, E, Bannen, R, Benz, J, Albert, T, Patel, J. Deposit date: 2017-02-24 Release date: 2017-10-04 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target. Sci Rep, 7, 2017
8B1G	DtpB-Nb132-AW Descriptor: ALA-TRP, DECANE, DODECANE, ... Authors: Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. Deposit date: 2022-09-09 Release date: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition. Cell Rep, 42, 2023
8B17	DtpB-Nb132-AWA Descriptor: ALA-TRP-ALA, DECANE, DODECANE, ... Authors: Killer, M, Finocchio, G, Lei, J, Jungnickel, K, Kotov, V, Steinke, J, Bartels, K, Strauss, J, Dupeux, F, Humm, A.S, Cornaciu, I, Marquez, J, Pardon, E, Steyeart, J, Loew, C. Deposit date: 2022-09-09 Release date: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition. Cell Rep, 42, 2023
1TW3	Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET) Descriptor: Carminomycin 4-O-methyltransferase, METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE, S-ADENOSYL-L-HOMOCYSTEINE Authors: Jansson, A, Koskiniemi, H, Mantsala, P, Niemi, J, Schneider, G. Deposit date: 2004-06-30 Release date: 2004-09-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products J.Biol.Chem., 279, 2004
5TDA	Crystal structure of the UBR-box domain from UBR2 in complex with RLWS N-degron Descriptor: ARG-LEU-TRP-SER peptide, E3 ubiquitin-protein ligase UBR2, ZINC ION Authors: Munoz-Escobar, J, Kozlov, G, Gehring, K. Deposit date: 2016-09-19 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (0.79 Å) Cite: Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase. Structure, 25, 2017
2DPM	DPNM DNA ADENINE METHYLTRANSFERASE FROM STREPTOCCOCUS PNEUMONIAE COMPLEXED WITH S-ADENOSYLMETHIONINE Descriptor: MERCURY (II) ION, PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1), S-ADENOSYLMETHIONINE Authors: Tran, P.H, Korszun, Z.R, Cerritelli, S, Springhorn, S.S, Lacks, S.A. Deposit date: 1998-09-03 Release date: 1998-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the DpnM DNA adenine methyltransferase from the DpnII restriction system of streptococcus pneumoniae bound to S-adenosylmethionine. Structure, 6, 1998
7JYA	Crystal structure of E3 ligase in complex with peptide Descriptor: ASN-ARG-ARG-ARG-ARG-TRP-ARG-GLU-ARG-GLN-ARG, Protein fem-1 homolog C, UNKNOWN ATOM OR ION Authors: Yan, X, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Dong, C, Structural Genomics Consortium (SGC) Deposit date: 2020-08-30 Release date: 2020-10-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Molecular basis for ubiquitin ligase CRL2 FEM1C -mediated recognition of C-degron. Nat.Chem.Biol., 17, 2021
8ZJE	Cryo-EM structure of kisspeptin receptor bound to TAK-448 Descriptor: ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Shen, S, Liu, H, Xu, H.E. Deposit date: 2024-05-14 Release date: 2024-07-03 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: Cryo-EM structure of kisspeptin receptor bound to TAK-448 To Be Published
5KEZ	Selective and potent inhibition of the glycosidase human amylase by the short and extremely compact peptide piHA from mRNA display Descriptor: ACE-DTY-PRO-TYR-SER-CYS-TRP-VAL-ARG-HIS-NH2, CALCIUM ION, CHLORIDE ION, ... Authors: Caner, S, Brayer, G.D. Deposit date: 2016-06-10 Release date: 2017-03-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides. Cell Chem Biol, 24, 2017

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