8FLF
 
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8FLE
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7AD8
 | | Core TFIIH-XPA-DNA complex with modelled p62 subunit | | Descriptor: | DNA (49-MER), DNA repair protein complementing XP-A cells, General transcription and DNA repair factor IIH helicase subunit XPB, ... | | Authors: | Koelmel, W, Kuper, J, Kisker, C. | | Deposit date: | 2020-09-14 | | Release date: | 2021-07-28 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair.
Nucleic Acids Res., 48, 2020
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8FKW
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8FL9
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6ZMI
 | | SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2020-07-02 | | Release date: | 2020-08-19 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
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6ZMO
 | | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2020-07-03 | | Release date: | 2020-08-19 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
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8FL4
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8FLC
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8FL3
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8FL7
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8FLB
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8G6J
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2) | | Descriptor: | (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 1,4-DIAMINOBUTANE, ... | | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | Deposit date: | 2023-02-15 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8G60
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | Deposit date: | 2023-02-14 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8G61
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) | | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | Deposit date: | 2023-02-14 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8G5Y
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | Deposit date: | 2023-02-14 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.29 Å) | | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8GLP
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure) | | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Watson, Z.L, Altman, R.B, Blanchard, S.C. | | Deposit date: | 2023-03-22 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (1.67 Å) | | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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2CQG
 | | Solution structure of the RNA binding domain of TAR DNA-binding protein-43 | | Descriptor: | TAR DNA-binding protein-43 | | Authors: | Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-20 | | Release date: | 2005-11-20 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the RNA binding domain of TAR DNA-binding protein-43
To be Published
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8G2E
 | | PKM2 bound to compound 2 | | Descriptor: | 1,2-ETHANEDIOL, 3-[(3-aminophenyl)methyl]-5-methyl-7-[methyl(oxidanyl)-$l^{3}-sulfanyl]pyridazino[4,5-b]indol-4-one, MAGNESIUM ION, ... | | Authors: | Stuckey, J.A. | | Deposit date: | 2023-02-03 | | Release date: | 2023-05-17 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.838 Å) | | Cite: | Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis.
Pharmaceuticals, 16, 2023
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7A08
 | | CryoEM Structure of cGAS Nucleosome complex | | Descriptor: | Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ... | | Authors: | Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P. | | Deposit date: | 2020-08-07 | | Release date: | 2020-09-23 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Nature, 587, 2020
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8H0W
 | | RNA polymerase II transcribing a chromatosome (type II) | | Descriptor: | DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H. | | Deposit date: | 2022-09-30 | | Release date: | 2022-12-07 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.
Nat Commun, 13, 2022
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7AST
 | | Apo Human RNA Polymerase III | | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | Authors: | Ramsay, E.P, Abascal-Palacios, G, Daiss, J.L, King, H, Gouge, J, Pilsl, M, Beuron, F, Morris, E, Gunkel, P, Engel, C, Vannini, A. | | Deposit date: | 2020-10-28 | | Release date: | 2020-12-23 | | Last modified: | 2020-12-30 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of human RNA polymerase III.
Nat Commun, 11, 2020
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2CS2
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7AHO
 | | RUVBL1-RUVBL2 heterohexameric ring after binding of RNA helicase DHX34 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | | Authors: | Lopez-Perrote, A, Rodriguez, C.F, Llorca, O. | | Deposit date: | 2020-09-25 | | Release date: | 2020-11-25 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.
Elife, 9, 2020
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2CUF
 | | Solution structure of the homeobox domain of the human hypothetical protein FLJ21616 | | Descriptor: | FLJ21616 protein | | Authors: | Ohnishi, S, Kigawa, T, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-05-26 | | Release date: | 2005-11-26 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the homeobox domain of the human hypothetical protein FLJ21616
To be Published
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