1PK8
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![BU of 1pk8 by Molmil](/molmil-images/mine/1pk8) | Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | Authors: | Brautigam, C.A, Chelliah, Y, Deisenhofer, J. | Deposit date: | 2003-06-05 | Release date: | 2004-03-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Tetramerization and ATP binding by a protein comprising the A, B, and C domains of rat synapsin I. J.Biol.Chem., 279, 2004
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1Q24
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![BU of 1q24 by Molmil](/molmil-images/mine/1q24) | PKA double mutant model of PKB in complex with MgATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, cAMP-dependent Protein Kinase Inhibitor, ... | Authors: | Gassel, M, Breitenlechner, C.B, Rueger, P, Jucknischke, U, Schneider, T, Huber, R, Bossemeyer, D, Engh, R.A. | Deposit date: | 2003-07-23 | Release date: | 2003-08-19 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT) J.Mol.Biol., 329, 2003
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3MSX
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![BU of 3msx by Molmil](/molmil-images/mine/3msx) | Crystal structure of RhoA.GDP.MgF3 in complex with GAP domain of ArhGAP20 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 20, ... | Authors: | Utepbergenov, D, Cooper, D.R, Derewenda, U, Derewenda, Z.S. | Deposit date: | 2010-04-29 | Release date: | 2011-03-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Mechanism of molecular specificity of RhoGAP domains towards small GTPases of RhoA family. To be Published
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1Q8W
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![BU of 1q8w by Molmil](/molmil-images/mine/1q8w) | The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077) | Descriptor: | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, cAMP-dependent protein kinase inhibitor, alpha form, ... | Authors: | Breitenlechner, C, Gassel, M, Hidaka, H, Kinzel, V, Huber, R, Engh, R.A, Bossemeyer, D. | Deposit date: | 2003-08-22 | Release date: | 2003-12-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure, 11, 2003
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2X0B
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![BU of 2x0b by Molmil](/molmil-images/mine/2x0b) | Crystal structure of human angiotensinogen complexed with renin | Descriptor: | ANGIOTENSINOGEN, RENIN | Authors: | Zhou, A, Wei, Z, Yan, Y, Carrell, R.W, Read, R.J. | Deposit date: | 2009-12-08 | Release date: | 2010-10-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.33 Å) | Cite: | A Redox Switch in Angiotensinogen Modulates Angiotensin Release. Nature, 468, 2010
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1QVI
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![BU of 1qvi by Molmil](/molmil-images/mine/1qvi) | Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom resolution: flexibility and function in the head | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Gourinath, S, Himmel, D.M, Brown, J.H, Reshetnikova, L, Szent-Gyrgyi, A.G, Cohen, C. | Deposit date: | 2003-08-27 | Release date: | 2003-12-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head. Structure, 11, 2003
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2QJC
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![BU of 2qjc by Molmil](/molmil-images/mine/2qjc) | Crystal structure of a putative diadenosine tetraphosphatase | Descriptor: | Diadenosine tetraphosphatase, putative, MANGANESE (II) ION, ... | Authors: | Sugadev, R, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-07-06 | Release date: | 2007-07-24 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural genomics of protein phosphatases. J.Struct.Funct.Genom., 8, 2007
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2QM7
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![BU of 2qm7 by Molmil](/molmil-images/mine/2qm7) | MeaB, A Bacterial Homolog of MMAA, Bound to GDP | Descriptor: | GTPase/ATPase, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION | Authors: | Hubbard, P.A, Padovani, D, Labunska, T, Mahlstedt, S.A, Banerjee, R, Drennan, C.L. | Deposit date: | 2007-07-14 | Release date: | 2007-08-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria. J.Biol.Chem., 282, 2007
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1Q8U
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![BU of 1q8u by Molmil](/molmil-images/mine/1q8u) | The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P | Descriptor: | (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, N-OCTANOYL-N-METHYLGLUCAMINE, cAMP-dependent protein kinase inhibitor, ... | Authors: | Breitenlechner, C, Gassel, M, Hidaka, H, Kinzel, V, Huber, R, Engh, R.A, Bossemeyer, D. | Deposit date: | 2003-08-22 | Release date: | 2003-12-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure, 11, 2003
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1Q93
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![BU of 1q93 by Molmil](/molmil-images/mine/1q93) | Crystal structure of a mutant of the sarcin/ricin domain from rat 28S rRNA | Descriptor: | SODIUM ION, SULFATE ION, Sarcin/Ricin 28S rRNA | Authors: | Correll, C.C, Beneken, J, Plantinga, M.J, Lubbers, M, Chan, Y.L. | Deposit date: | 2003-08-22 | Release date: | 2003-11-25 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The common and distinctive features of the bulged-G motif based on a 1.04 A resolution RNA structure Nucleic Acids Res., 31, 2003
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2R4E
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![BU of 2r4e by Molmil](/molmil-images/mine/2r4e) | Crystal structure of Escherichia coli Glycerol-3-phosphate Dehydrogenase in complex with DHAP | Descriptor: | 1,2-ETHANEDIOL, 1,3-DIHYDROXYACETONEPHOSPHATE, Aerobic glycerol-3-phosphate dehydrogenase, ... | Authors: | Yeh, J.I, Du, S, Chinte, U. | Deposit date: | 2007-08-31 | Release date: | 2008-04-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism. Proc.Natl.Acad.Sci.Usa, 105, 2008
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2QS2
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![BU of 2qs2 by Molmil](/molmil-images/mine/2qs2) | Crystal structure of the GluR5 ligand binding core dimer in complex with UBP318 at 1.80 Angstroms resolution | Descriptor: | 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-bromo-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)thiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ... | Authors: | Alushin, G.M, Jane, D.E, Mayer, M.L. | Deposit date: | 2007-07-30 | Release date: | 2008-08-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
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1QQP
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![BU of 1qqp by Molmil](/molmil-images/mine/1qqp) | FOOT-AND-MOUTH DISEASE VIRUS/ OLIGOSACCHARIDE RECEPTOR COMPLEX. | Descriptor: | 2-O-sulfo-alpha-L-gulopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-gulopyranuronic acid, PROTEIN (GENOME POLYPROTEIN) | Authors: | Fry, E.E, Lea, S.M, Jackson, T, Newman, J.W.I, Ellard, F.M, Blakemore, W.E, Abu-Ghazaleh, R, Samuel, A, King, A.M.Q, Stuart, D.I. | Deposit date: | 1999-05-20 | Release date: | 1999-06-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex. EMBO J., 18, 1999
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2SPM
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![BU of 2spm by Molmil](/molmil-images/mine/2spm) | |
2SPN
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![BU of 2spn by Molmil](/molmil-images/mine/2spn) | A NOVEL SITE-DIRECTED MUTANT OF MYOGLOBIN WITH AN UNUSUALLY HIGH O2 AFFINITY AND LOW AUTOOXIDATION RATE | Descriptor: | MYOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Quillin, M.L, Arduini, R.M, Phillips Jr, G.N. | Deposit date: | 1993-08-25 | Release date: | 1994-01-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A novel site-directed mutant of myoglobin with an unusually high O2 affinity and low autooxidation rate. J.Biol.Chem., 267, 1992
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2SPO
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![BU of 2spo by Molmil](/molmil-images/mine/2spo) | |
2RCA
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![BU of 2rca by Molmil](/molmil-images/mine/2rca) | |
1PV3
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![BU of 1pv3 by Molmil](/molmil-images/mine/1pv3) | NMR Solution Structure of the Avian FAT-domain of Focal Adhesion Kinase | Descriptor: | Focal adhesion kinase 1 | Authors: | Prutzman, K.C, Gao, G, King, M.L, Iyer, V.V, Mueller, G.A, Schaller, M.D, Campbell, S.L. | Deposit date: | 2003-06-26 | Release date: | 2004-05-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The Focal Adhesion Targeting Domain of Focal Adhesion Kinase Contains a Hinge Region that Modulates Tyrosine 926 Phosphorylation. STRUCTURE, 12, 2004
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1PZ9
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![BU of 1pz9 by Molmil](/molmil-images/mine/1pz9) | Modulation of agrin function by alternative splicing and Ca2+ binding | Descriptor: | Agrin | Authors: | Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A. | Deposit date: | 2003-07-10 | Release date: | 2004-04-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Modulation of agrin function by alternative splicing and Ca2+ binding. STRUCTURE, 12, 2004
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2XH6
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![BU of 2xh6 by Molmil](/molmil-images/mine/2xh6) | Clostridium perfringens enterotoxin | Descriptor: | 1,4-DIETHYLENE DIOXIDE, HEAT-LABILE ENTEROTOXIN B CHAIN, octyl beta-D-glucopyranoside | Authors: | Briggs, D.C, Naylor, C.E, Smedley III, J.G, MCClane, B.A, Basak, A.K. | Deposit date: | 2010-06-09 | Release date: | 2011-04-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structure of the Food-Poisoning Clostridium Perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins J.Mol.Biol., 413, 2011
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2R1V
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2QTB
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![BU of 2qtb by Molmil](/molmil-images/mine/2qtb) | Human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl cyclohexylalanine inhibitor | Descriptor: | (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Scapin, G. | Deposit date: | 2007-08-01 | Release date: | 2007-11-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | 4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV. Bioorg.Med.Chem.Lett., 17, 2007
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2QU6
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![BU of 2qu6 by Molmil](/molmil-images/mine/2qu6) | Crystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor | Descriptor: | 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide, SULFATE ION, Vascular endothelial growth factor receptor 2 | Authors: | Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H. | Deposit date: | 2007-08-03 | Release date: | 2007-09-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors. J.Med.Chem., 50, 2007
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2QJR
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![BU of 2qjr by Molmil](/molmil-images/mine/2qjr) | dipepdyl peptidase IV in complex with inhibitor PZF | Descriptor: | (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shenping, L. | Deposit date: | 2007-07-09 | Release date: | 2008-07-29 | Last modified: | 2022-04-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorg.Med.Chem.Lett., 17, 2007
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2R1T
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![BU of 2r1t by Molmil](/molmil-images/mine/2r1t) | |