5KFI
 
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5KFT
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5KG5
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5KFB
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5KFM
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5KFW
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3LSQ
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5KN7
 | | Lipid A secondary acyltransferase LpxM from Acinetobacter baumannii | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, GLYCEROL, Lipid A biosynthesis lauroyl acyltransferase, ... | | Authors: | Dovala, D.L, Hu, Q, Metzger IV, L.E. | | Deposit date: | 2016-06-27 | | Release date: | 2016-09-28 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5KJ2
 | | The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer | | Descriptor: | Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION | | Authors: | Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C. | | Deposit date: | 2016-06-17 | | Release date: | 2017-09-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Nature, 550, 2017
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5KLH
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7WNZ
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2D32
 | | Crystal Structure of Michaelis Complex of gamma-Glutamylcysteine Synthetase | | Descriptor: | CYSTEINE, GLUTAMIC ACID, Glutamate--cysteine ligase, ... | | Authors: | Hibi, T, Nakayama, M, Nii, H, Kurokawa, Y, Katano, H, Oda, J. | | Deposit date: | 2005-09-25 | | Release date: | 2006-11-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of efficient coupling peptide ligation and ATP hydrolysis by gamma-gluatamylcysteine synthetase
To be Published
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6GQ4
 | | Neisseria gonorrhoeae Adhesin Complex Protein | | Descriptor: | Adhesin, SODIUM ION | | Authors: | Orr, C.M, Tews, I. | | Deposit date: | 2018-06-07 | | Release date: | 2018-09-19 | | Last modified: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure of the RecombinantNeisseria gonorrhoeaeAdhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci.
mSphere, 3, 2018
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1WTU
 | | TRANSCRIPTION FACTOR 1, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | TRANSCRIPTION FACTOR 1 | | Authors: | Jia, X, Grove, A, Ivancic, M, Hsu, V.L, Geiduschek, E.P, Kearns, D.R. | | Deposit date: | 1996-07-29 | | Release date: | 1997-02-12 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of the Bacillus subtilis phage SPO1-encoded type II DNA-binding protein TF1 in solution.
J.Mol.Biol., 263, 1996
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7WWO
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7WWN
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5KNK
 | | Lipid A secondary acyltransferase LpxM from Acinetobacter baumannii with catalytic residue substitution (E127A) | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, GLYCEROL, Lipid A biosynthesis lauroyl acyltransferase, ... | | Authors: | Dovala, D.L, Hu, Q, Metzger IV, L.E. | | Deposit date: | 2016-06-28 | | Release date: | 2016-09-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
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2D33
 | | Crystal Structure of gamma-Glutamylcysteine Synthetase Complexed with Aluminum Fluoride | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CYSTEINE, ... | | Authors: | Hibi, T, Nakayama, M, Nii, H, Kurokawa, Y, Katano, H, Oda, J. | | Deposit date: | 2005-09-25 | | Release date: | 2006-11-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of efficient coupling between peptide ligation and ATP hydrolysis by gamma-gluatamylcysteine synthetase
To be Published
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3LIM
 | | Crystal structure of the pore forming toxin frac from sea anemone actinia fragacea | | Descriptor: | Fragaceatoxin C, LAURYL DIMETHYLAMINE-N-OXIDE | | Authors: | Mechaly, A.E, Bellomio, A, Morante, K, Gonzalez-Manas, J.M, Guerin, D.M.A. | | Deposit date: | 2010-01-25 | | Release date: | 2010-12-15 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins.
Structure, 19, 2011
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4TPP
 | | 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors | | Descriptor: | 1-[4-(3-{[1-(quinolin-2-yl)azetidin-3-yl]oxy}quinoxalin-2-yl)piperidin-1-yl]ethanone, GLYCEROL, SULFATE ION, ... | | Authors: | Chmait, S. | | Deposit date: | 2014-06-09 | | Release date: | 2014-12-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.
Bioorg.Med.Chem., 22, 2014
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6UEX
 | | Crystal structure of S. aureus LcpA in complex with octaprenyl-pyrophosphate-GlcNAc | | Descriptor: | 2-(acetylamino)-2-deoxy-1-O-[(S)-hydroxy{[(S)-hydroxy{[(2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl]oxy}phosphoryl]oxy}phosphoryl]-alpha-D-glucopyranose, GLYCEROL, Regulatory protein MsrR, ... | | Authors: | Li, F.K.K, Strynadka, N.C.J. | | Deposit date: | 2019-09-23 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystallographic analysis ofStaphylococcus aureusLcpA, the primary wall teichoic acid ligase.
J.Biol.Chem., 295, 2020
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7X5V
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5KMX
 | | Structure of Trypanosoma congolense Insect Stage Antigen | | Descriptor: | GLYCEROL, Putative uncharacterized protein TCIL3000_10_9440, SULFATE ION | | Authors: | Ramaswamy, R, Parker, M.L, Boulanger, M.J. | | Deposit date: | 2016-06-27 | | Release date: | 2017-07-05 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.452 Å) | | Cite: | Structural characterization reveals a novel bilobed architecture for the ectodomains of insect stage expressed Trypanosoma brucei PSSA-2 and Trypanosoma congolense ISA.
Protein Sci., 25, 2016
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4Z9O
 | | Crystal Structure of human GGT1 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Terzyan, S.S, Hanigan, M.H. | | Deposit date: | 2015-04-10 | | Release date: | 2015-06-03 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS.
J.Biol.Chem., 290, 2015
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6H8S
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