2YKI
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![BU of 2yki by Molmil](/molmil-images/mine/2yki) | Tricyclic series of Hsp90 inhibitors | Descriptor: | 1-H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID [4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL]-AMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA | Authors: | Dupuy, A, Vallee, F. | Deposit date: | 2011-05-27 | Release date: | 2011-10-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
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2GIL
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![BU of 2gil by Molmil](/molmil-images/mine/2gil) | Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-6A | Authors: | Bergbrede, T, Pylypenko, O, Rak, A, Alexandrov, K. | Deposit date: | 2006-03-29 | Release date: | 2006-06-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution J.STRUCT.BIOL., 152, 2005
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2YA7
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![BU of 2ya7 by Molmil](/molmil-images/mine/2ya7) | Crystal structure of Streptococcus pneumoniae NanA (TIGR4) in complex with Zanamivir | Descriptor: | CHLORIDE ION, NEURAMINIDASE A, ZANAMIVIR | Authors: | Gut, H, Xu, G, Taylor, G.L, Walsh, M.A. | Deposit date: | 2011-02-18 | Release date: | 2011-04-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural Basis for Streptococcus Pneumoniae Nana Inhibition by Influenza Antivirals Zanamivir and Oseltamivir Carboxylate. J.Mol.Biol., 409, 2011
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8TE6
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![BU of 8te6 by Molmil](/molmil-images/mine/8te6) | |
8TE5
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![BU of 8te5 by Molmil](/molmil-images/mine/8te5) | |
5E4X
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![BU of 5e4x by Molmil](/molmil-images/mine/5e4x) | Crystal structure of cpSRP43 chromodomain 3 | Descriptor: | MAGNESIUM ION, Signal recognition particle 43 kDa protein, chloroplastic | Authors: | Horn, A, Ahmed, Y.L, Wild, K, Sinning, I. | Deposit date: | 2015-10-07 | Release date: | 2015-12-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction. Nat Commun, 6, 2015
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8SX4
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![BU of 8sx4 by Molmil](/molmil-images/mine/8sx4) | Crystal Structure of eIF4e in complex with Compound 7n | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E, [(~{Z})-4-[2-azanyl-7-[(5-chloranyl-1~{H}-indol-2-yl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]but-2-enyl]phosphonic acid | Authors: | Meagher, J.L, Stuckey, J.A. | Deposit date: | 2023-05-19 | Release date: | 2023-06-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.986 Å) | Cite: | Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer. J.Med.Chem., 66, 2023
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8T55
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![BU of 8t55 by Molmil](/molmil-images/mine/8t55) | Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654 | Descriptor: | 1,2-ETHANEDIOL, N-[3-(4-chlorophenyl)oxetan-3-yl]-1-propanoyl-1,2,3,4-tetrahydroquinoline-5-carboxamide, WD repeat-containing protein 91 | Authors: | Ahmad, H, Zeng, H, Dong, A, Li, Y, Yen, H, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Santhakumar, V, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2023-06-12 | Release date: | 2023-07-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J.Med.Chem., 66, 2023
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8ST8
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2G9C
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![BU of 2g9c by Molmil](/molmil-images/mine/2g9c) | Modified pyrimidines Specifically bind the purine riboswitch | Descriptor: | ACETATE ION, COBALT HEXAMMINE(III), PYRIMIDINE-2,4,6-TRIAMINE, ... | Authors: | Gilbert, S.D, Mediatore, S.J, Batey, R.T. | Deposit date: | 2006-03-06 | Release date: | 2006-11-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Modified pyrimidines specifically bind the purine riboswitch. J.Am.Chem.Soc., 128, 2006
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8SRM
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8T1C
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![BU of 8t1c by Molmil](/molmil-images/mine/8t1c) | Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4-Enhanced green fluorescent protein chimera | Authors: | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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2YKR
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![BU of 2ykr by Molmil](/molmil-images/mine/2ykr) | 30S ribosomal subunit with RsgA bound in the presence of GMPPNP | Descriptor: | 16S RRNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... | Authors: | Guo, Q, Yuan, Y, Xu, Y, Feng, B, Liu, L, Chen, K, Lei, J, Gao, N. | Deposit date: | 2011-05-30 | Release date: | 2011-08-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | Structural Basis for the Function of a Small Gtpase Rsga on the 30S Ribosomal Subunit Maturation Revealed by Cryoelectron Microscopy. Proc.Natl.Acad.Sci.USA, 108, 2011
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8T1O
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![BU of 8t1o by Molmil](/molmil-images/mine/8t1o) | AP2 bound to MSP2N2 nanodisc with Tgn38 cargo peptide; composite map | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | Authors: | Baker, R.W, Cannon, K.S, Reta, S. | Deposit date: | 2023-06-02 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Lipid nanodiscs as a template for high-resolution cryo-EM structures of peripheral membrane proteins. J.Struct.Biol., 215, 2023
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2G8Q
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8SU4
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![BU of 8su4 by Molmil](/molmil-images/mine/8su4) | F198S epi-Isozizaene Synthase: complex with 3 Mg2+, inorganic pyrophosphate, and benzyl triethyl ammonium cation | Descriptor: | Epi-isozizaene synthase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Eaton, S.A, Christianson, D.W. | Deposit date: | 2023-05-11 | Release date: | 2023-07-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Reprogramming the Cyclization Cascade of epi -Isozizaene Synthase to Generate Alternative Terpene Products. Biochemistry, 62, 2023
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5E89
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![BU of 5e89 by Molmil](/molmil-images/mine/5e89) | Crystal structure of Human galectin-3 CRD in complex with 3-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor | Descriptor: | 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, CHLORIDE ION, Galectin-3 | Authors: | Collins, P.M, Blanchard, H. | Deposit date: | 2015-10-13 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. Chembiochem, 17, 2016
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2YQR
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![BU of 2yqr by Molmil](/molmil-images/mine/2yqr) | Solution structure of the KH domain in KIAA0907 protein | Descriptor: | KIAA0907 protein | Authors: | Kadirvel, S, He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Tarada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-30 | Release date: | 2007-10-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the KH domain in KIAA0907 protein To be Published
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8SU1
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8SU3
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![BU of 8su3 by Molmil](/molmil-images/mine/8su3) | F95S epi-Isozizaene Synthase: complex with 3 Mg2+, inorganic pyrophosphate, and benzyl triethyl ammonium cation | Descriptor: | Epi-isozizaene synthase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Eaton, S.A, Christianson, D.W. | Deposit date: | 2023-05-11 | Release date: | 2023-07-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Reprogramming the Cyclization Cascade of epi -Isozizaene Synthase to Generate Alternative Terpene Products. Biochemistry, 62, 2023
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2YRL
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![BU of 2yrl by Molmil](/molmil-images/mine/2yrl) | |
5E6F
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![BU of 5e6f by Molmil](/molmil-images/mine/5e6f) | Canarypox virus resolvase | Descriptor: | CNPV261 Holliday junction resolvase protein, D(-)-TARTARIC ACID, MAGNESIUM ION | Authors: | Li, H, Hwang, Y, Perry, K, Bushman, F.D, Van Duyne, G.D. | Deposit date: | 2015-10-09 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure and Metal Binding Properties of a Poxvirus Resolvase. J.Biol.Chem., 291, 2016
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8TBX
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![BU of 8tbx by Molmil](/molmil-images/mine/8tbx) | Crystal structure of human DDX1 helicase in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX1, MAGNESIUM ION, ... | Authors: | Zeng, H, Dong, A, Li, Y, Yen, H, Hejazi, Z, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L. | Deposit date: | 2023-06-29 | Release date: | 2023-07-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Crystal structure of human DDX1 helicase in complex with ADP To be published
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8SU2
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2YSE
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![BU of 2yse by Molmil](/molmil-images/mine/2yse) | Solution structure of the second WW domain from the human membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1. MAGI-1 | Descriptor: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | Authors: | Ohnishi, S, Sato, M, Koshiba, S, Harada, T, Watanabe, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-03 | Release date: | 2007-10-09 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the second WW domain from the human membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1. MAGI-1 To be Published
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